redsun
Member
- Joined
- Dec 17, 2018
- Messages
- 3,013
Do you think the increase in vascularity could be due to an increase in histamine?
The folic acid likely did something in regards to histamine by helping retain histidine and I used to think histamine mainly caused the vascularity now I am not sure. I am not aware of any histamine raising properties of B2 though there is a direct need for it in the methylation cycle. Someone told me you need B2 and folic acid for nitric oxide synthase and those two are basically the most important. And when you check online you need FAD and FMN, NADPH, iron of course with oxygen and BH4(from folic acid).
So big thing here is I lost my vascularity when I got a bad knee injury over a year and a half ago. This seems to fall in line with the idea of needing nitric oxide after a injury with its role in inflammation and increasing blood flow where needed. My knee was swollen like hell so yeh perhaps this is what happened, I became depleted in folic acid and B2. And when I repleted both NOS worked again. I don't know of another explanation on why specifically B2 and folic acid can cause such an insane vascularity.
BH4 is used in most neurotransmitters but I don't recall any that can increase vasodilation as I dont read much about it. Nitric oxide is obviously considered undesirable generally, but clearly it is very needed for some things if it seems to be raised by repletion of micronutrients. This vascularity seems to be 24/7 now unless Im out in very cold weather so basically the same now when I was younger.
The role of histidine in the anemia of folate deficiency. - PubMed - NCBI
Studies on the influence of folic acid and riboflavin on nitric oxide production in cultured murine macrophage cells