What do i add to gaba powder to force it through the blood brain barrier?

[ndn]

the formulas sold dont really do it for me ... i was told by someone i can't find or reach that there was something that does it ... was it rhodiola? passion flower and inositol don't do it for me .

 

[thesmileyone]

threonate?

 

[Cuberunner]

Maybe take it on an empty stomach, exercise afterwards. I built a cross tolerance from supplemental gaba and phenibut, felt wds. I wouldn't take it frequently even if u don't feel it much.

 

[nomoreketones]

I don't know if this is outdated but it was once recommended to take taurine instead of Gaba. But I think taurine has the same problems with the blood brain barrier.

GABA Supplements - Real Or Not ?

How are GABA suppliments supposed to work, if, they can't do much iin terms of crossing the blood-brain-barrior? I thought I'd give then a try for sleep/anxiety...

raypeatforum.com

 

[aliml]

P-glycoprotein inhibitors and Bag breathing (CO2) may open the blood brain barrier.

Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition - PubMed

Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be responsible for MDR and making the treatment regimens ineffective. In this review, we discuss MDR in relation to...

pubmed.ncbi.nlm.nih.gov

Inhibition of P-glycoprotein at the Blood–Brain Barrier by Phytochemicals Derived from Traditional Chinese Medicine

The blood–brain barrier (BBB) is a key determinant for drug transport through brain vessels. It restricts the pharmacological efficacy in numerous neurological diseases, including brain tumors. A major functional constituent of BBB is P-glycoprotein, which is also a major obstacle for effective...

cgp.iiarjournals.org

 

[Grapelander]

Theanine is supposed to help. (1)
Phenibut works but becomes addictive. (2)

Apparently their is a GABA Transporter (GAT-2) and a Betaine/GABA Transporter (BGT-1)
GABA uptake by TM-BBB cells was significantly inhibited by betaine, beta-alanine, nipecotic acid, taurine, and quinidine, whereas probenecid, L-proline, creatine, and glycine had no effect. (3)