Ways To Lower/Inhibit IGF-1?

[Adrenaline]

Seems like there are lot of IGF-1 promoters but not inhibitors.

As you know IGF-1 has lot of deleterious effects. Cancer, cardiovascular diseases, organ damage hair loss, acne..

So how to lower IGF-1? I searched PubMed and I will start with Nifedipine (Calcium Channel Blocker)

 

[sun-maid]

No, its TGF-B1 that is bad. IGF-1 is good

 

[Markus]

Fasting, protein restriction and avoiding high-glycemic carbohydrates that lead to hyperinsulinemia.

 

[Adrenaline]

No, its TGF-B1 that is bad. IGF-1 is good

If you search PubMed a little, you will see that it has harmful effects. Peat also against those growth hormones - factors.

 

[Inaut]

I believe Peat has said it is a growth promoter and that it can be a good and a bad thing. I'm paraphrasing (poor job I know) but I heard it on an interview the other day.

 

[GreekDemiGod]

• Keto + Intermittent Fasting
• Low protein diet in general
• good insulin sensitivity by itself will regulate IGF1

 

[Hans]

If you search PubMed a little, you will see that it has harmful effects. Peat also against those growth hormones - factors.

It's a dysregulation of IGF-1 handling that's the issue, and things like hyperinsulinemia and estrogen, both of which promote IGF-1.

 

[baccheion]

It's a dysregulation of IGF-1 handling that's the issue, and things like hyperinsulinemia and estrogen, both of which promote IGF-1.

So IGF-1 near the middle or top of the range isn't necessarily problematic?

 

[Markus]

So IGF-1 near the middle or top of the range isn't necessarily problematic?

The ideal range for IGF-1 is between 100-150 ug/L.

 

[Hans]

So IGF-1 near the middle or top of the range isn't necessarily problematic?

I don't think so. The median serum IGF-I level is 374.1 ng/ml at the age of 18. Given that we continue to grow and mature up to 40, I don't think we should try to lower it. But because growth isn't as rapid anymore after puberty, unless we try to build muscle, it doesn't have to be sky high.
But all natural things that increase IGF-1, like vitamin D, calcium, magnesium, DHEA, zinc, etc., shouldn't be limited to minimize IGF-1, because then deficiencies might occur. Plus, all those natural stuff that increase IGF-1 are highly beneficial for us.

 

[ExCarniv]

• Keto + Intermittent Fasting

• Low protein diet in general

So, is bad then lol