unexamined_whimsy
Member
- Joined
- Apr 21, 2013
- Messages
- 181
Like many here, I have been struggling to control the side effects of T3 and pro-thyroid substances that include aspirin, coffee and pregnenolone (However, DHEA in low doses, like @haidut recommends is OK.). Here is my correspondence with Ray on this matter.
What’s interesting in my case is that using aromatase inhibitors doesn’t fix the water retention problem, it barely makes a dent; it does improve EQ and morning wood though. So, I think Ray’s suggestion of it being an adrenaline increase is very interesting.
I’m wondering, is this adrenaline increase due to a deficiency of nutrients, or the inability of the liver to store enough glycogen? What steps can one take to reduce adrenaline? Some here (@docall18) have had limited success with vitamin B6 as an adjunct to pro-thyroid substances but at a dosage that far exceeds Ray’s recommendations. Is there a way to *obliterate* adrenaline to test this hypothesis?
Dear Dr. Peat,
I’m 34/male.
Why would T3 or something like high-dose caffeine+aspirin induce water retention, often within minutes of ingestion? It also happens at a lower dose of the pro-thyroid substance when followed by a burst of physical activity. Strangely, simply high-dose caffeine improves body tone at the expense of a very shrunken penis owing perhaps to its progesterone increasing effect. It manifests itself as puffiness of the chest and abdomen. My thighs become much larger and jiggly while my calve muscles lose definition. The overall puffiness usually resolves at least partially overnight. I also have spider angiomas on the inside of my thighs close to the knee indicating high oestrogen. However, the strange thing is that the water-retention problem doesn’t really go away even using strong aromatase inhibitors like letrozole or exemestane, neither with a few weeks of high dose zinc or even vitamin E.
Are there circumstances when exogenous thyroid or pro-thyroid substances can lead to an elevation in the body’s oestrogen load? The usual explanation from the literature is that excess thyroid increases SHBG levels and because of the different binding capabilities of the steroids to the SHBG, the effective androgenic/oestrogen ratio is adversely affected. Others suggest that thyroid is flushing the oestrogen from the tissues and into the bloodstream; it’s an intermediate state one has to soldier through. Some argue about a copper toxicity syndrome. And there are those who argue for nutrient deficiencies, or even a down regulation of 5aR activity.
A lot of folks on raypeatforum.com also report similar experiences, so I was wondering if you could shed some light on why this is happening?
I’m 34/male.
Why would T3 or something like high-dose caffeine+aspirin induce water retention, often within minutes of ingestion? It also happens at a lower dose of the pro-thyroid substance when followed by a burst of physical activity. Strangely, simply high-dose caffeine improves body tone at the expense of a very shrunken penis owing perhaps to its progesterone increasing effect. It manifests itself as puffiness of the chest and abdomen. My thighs become much larger and jiggly while my calve muscles lose definition. The overall puffiness usually resolves at least partially overnight. I also have spider angiomas on the inside of my thighs close to the knee indicating high oestrogen. However, the strange thing is that the water-retention problem doesn’t really go away even using strong aromatase inhibitors like letrozole or exemestane, neither with a few weeks of high dose zinc or even vitamin E.
Are there circumstances when exogenous thyroid or pro-thyroid substances can lead to an elevation in the body’s oestrogen load? The usual explanation from the literature is that excess thyroid increases SHBG levels and because of the different binding capabilities of the steroids to the SHBG, the effective androgenic/oestrogen ratio is adversely affected. Others suggest that thyroid is flushing the oestrogen from the tissues and into the bloodstream; it’s an intermediate state one has to soldier through. Some argue about a copper toxicity syndrome. And there are those who argue for nutrient deficiencies, or even a down regulation of 5aR activity.
A lot of folks on raypeatforum.com also report similar experiences, so I was wondering if you could shed some light on why this is happening?
Have you checked your weight before and after those events, and noticed the quanties of urine afterward? It could be that the changes are produced by shifts in circulation and muscle tone. Too much caffeine can cause a surge of adrenaline, which can cause shifts of fluids and tone.
What’s interesting in my case is that using aromatase inhibitors doesn’t fix the water retention problem, it barely makes a dent; it does improve EQ and morning wood though. So, I think Ray’s suggestion of it being an adrenaline increase is very interesting.
I’m wondering, is this adrenaline increase due to a deficiency of nutrients, or the inability of the liver to store enough glycogen? What steps can one take to reduce adrenaline? Some here (@docall18) have had limited success with vitamin B6 as an adjunct to pro-thyroid substances but at a dosage that far exceeds Ray’s recommendations. Is there a way to *obliterate* adrenaline to test this hypothesis?