Was Otto Warburg Wrong?

[Mito]

Brief summary - Rosedale believes that cancer is not genetic but he also doesn't believe in the metabolic theory either. He explains why cancer is not caused by defective mitochondrial function. He believes cancer is caused by too much IGF-1, leptin, and mTOR due to dietary protein. He recommends not eating a high protein diet to prevent cancer. He defines high protein as more than 1 gram/kg (or .45 grams/lb) of estimated lean body weight per day. His recommendation for protein is 0.75 grams/kg of estimated lean body weight.

 

[Markus]

If I eat that little protein I wither away.

 

[tankasnowgod]

Brief summary - Rosedale believes that cancer is not genetic but he also doesn't believe in the metabolic theory either. He explains why cancer is not caused by defective mitochondrial function. He believes cancer is caused by too much IGF-1, leptin, and mTOR due to dietary protein. He recommends not eating a high protein diet to prevent cancer. He defines high protein as more than 1 gram/kg (or .45 grams/lb) of estimated lean body weight per day. His recommendation for protein is 0.75 grams/kg of estimated lean body weight.
https://youtu.be/F5HXCfimEa4

Isn't the REAL question whether Rosedale will be speaking on next year's Low Carb Cruise?

 

[Zigzag]

That's a recipe to feel like garbage.

 

[Dobbler]

I recommend listening Georgi Dinkov (Haidut) on Matt Blackburns mitolife radio podcast "Estrogen, progesterone and resveratrol" , Haidut explains cancer so well and ELI5 i have listened it like 5 times .

 

[LeeLemonoil]

That all is reductionist pseudo-science.

Yes, mTor, IGF-1 and leptine resistence are all bad and probably pro-cancerous IN CONTEXT. Chronic dominance of these signaling activated surely would be part of pro-cancerous context. But that still is not sufficient for malignant cancer to form and foster.

It’s: I know something of biochemistry and cell-biology and this is what I rationalize and postulate. We all do it.

 

[LeeLemonoil]

The question is: when all these pathways are chronically dominant, does that alone creates cancer? Very likely not.

Are other causes for cancer more likely to blossom if theses are constantly overactive? Very likely yes.

Is Rosedales conclusion thus correct? No, not in its postulatory absolutism and not in him describing the actual causative pathways

 

[ExCarniv]

Another low carb quack.

 

[Risingfire]

He's very thin, not very healthy

 

[Amazoniac]

Interesting presentation, thank you for sharing!

- Landmark study shows acute myeloid leukaemia is at least 11 different diseases
- Study unmasks the genetic complexity of cancer cells within the same tumor
- Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis
- Simple sugar, lactate, is like 'candy for cancer cells': Cancer cells accelerate aging and inflammation in the body to drive tumor growth
- Lactate Metabolism is Associated with Mammalian Mitochondria
- Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress
- PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
- Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition
- Ketones and lactate increase cancer cell “stemness”, driving recurrence, metastasis and poor clinical outcome in breast cancer: Achieving personalized medicine via metabolo-genomics
- Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
- Fundamentals of cancer metabolism
- Otto Warburg’s contributions to current concepts of cancer metabolism
- Observations on the carbohydrate metabolism of tumours
- Energy Metabolism in the Acquisition and Maintenance of Stemness
- Mitochondrial Dysfunction in Cancer Cells Due to Aberrant Mitochondrial Replication
- Metabolic implication of tumor: Stroma crosstalk in breast cancer
- Cancer as a mitochondrial metabolic disease
- Preservation of Normal Behavior by Enucleated Cells in Culture
- Mitochondrial dysfunction and longevity in animals: Untangling the knot
- Understanding the intersections between metabolism and cancer biology
- Mapped Biochemical Pathways | Roche
- The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

Kids have orderly growth..

 

[LeeLemonoil]

Thanks @Amazoniac for that Compilation

 

[CLASH]

Besides the reductive biochemical arguments, i dont think this is even historically supported.

 

[Rick K]

Brief summary - Rosedale believes that cancer is not genetic but he also doesn't believe in the metabolic theory either. He explains why cancer is not caused by defective mitochondrial function. He believes cancer is caused by too much IGF-1, leptin, and mTOR due to dietary protein. He recommends not eating a high protein diet to prevent cancer. He defines high protein as more than 1 gram/kg (or .45 grams/lb) of estimated lean body weight per day. His recommendation for protein is 0.75 grams/kg of estimated lean body weight.
https://youtu.be/F5HXCfimEa4

So if Warburg was wrong then so was Koch? He also verified the mitochondrial malfunction and lactate as the fuel driving tumor growth and presented evidence to halt and reverse cancer and restore mitochondrial health with glucose being returned as cell fuel. Someone's meds must be past the expiry date.