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Vitamin K2 Directly Inhibits New Estrogen Synthesis

Discussion in 'Scientific Studies' started by haidut, Dec 19, 2014.

  1. haidut

    haidut Member

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    There are some studies on vitamin K2 (MK-4) being aromatase inhibitor and also a study showing in higher doses it increased testosterone levels. This study shows that vitamin K2 (MK-4) directly inhibits the enzyme responsible for the conversion of DHEA into estrogen, so maybe adding some vitamin K (MK-4) to the DHEA regimen will make DHEA supplementation safer. However, no word on dosing.

    Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism. - PubMed - NCBI

    "...The results indicated that 17beta hydroxy steroid dehydrogenase 4, apolipoportein E, and 40S ribosomal proteins S7 and S13 might be the candidates of the vitamin K-binding proteins. Subsequent experiments showed that vitamin K2 binds 17beta hydroxysteroid dehydrogenase 4 and decreases the intracellular estradiol:estrone ratio, which resulted in the inhibition of the amount of estrogen receptor alpha-binding to its target DNA. These results suggest a possible novel role for vitamin K in modulating estrogen function."
     
  2. narouz

    narouz Member

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    Thanks, haidut!
     
  3. north

    north Member

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    Awesome!
     
  4. sladerunner69

    sladerunner69 Member

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    The only economically viable k-2 I have found, has the first "other ingredient" being soybean oil :cry:

    I wonder if it's enough to be counter productive.... Also Peat has stated k-1 t also be effective because k-1 is converted to k-2 as needed through various pathways.

    Not to mention a bottle of k1 at gnc costs about 3 buckaroos where k-2 can be more like 30 :2cents
     
  5. Spondive

    Spondive Member

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    Where can you get K1 at higher doses..most are in the mcg amounts...the only ones I found are for animals in the 25 and 50 mg range
     
  6. Murtaza

    Murtaza Member

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    Is this a typo? Shouldnt it be K instead of E? @haidut
     
  7. Arrade

    Arrade Member

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    Excellent
    @haidut can you overdose on Vitmain K? I was considering taking 95mg daily for an extended period
     
  8. OP
    haidut

    haidut Member

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    Yes, it was a typo. Thanks for pointing it out, it is fixed now.
     
  9. OP
    haidut

    haidut Member

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    Well, you can overdose on anything but the LD50 for vitamin K2 is really high which shows it is non-toxic. The studies in rats that used very high doses equivalent to grams per day in a human did not find any issues and human studies have used 45mg x 3 (135mg) daily for more than 12 months without major issues. The officially recommended dose by the original studies in Japan for osteoporosis and prostate cancer says the recommended dose is 1mg/kg, so for most people that would be more than 45mg daily. The 45mg dose became (unfortunately) quoted as the recommended one since the studies for osteoporosis used elderly Asian women whose weight rarely exceeded 50kg. Japanese studies continue to mention the 1mg/kg dose but the West has somehow convinced itself that the dose is 45mg daily regardless of weight/size, which is obviously not true for any drug including K2.
     
  10. Arrade

    Arrade Member

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    Fascinating, thanks for the thoroughness of your response. Since I weigh 80 kg I will supplement around 75 mg - 90 mg.
     
  11. johnwester130

    johnwester130 Member

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    of k2 ??

    a bottle wouldn't last long on that amount
     
  12. Arrade

    Arrade Member

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    Of Mk4 specifically.
    Amazon holds a brand of nutraceuticals called “Relentless Improvement” and for $30 you can have a month supply of 45mg.
    I don’t have osteoporosis though and will continue to use the LEF complex, so perhaps 45mg for a few months to note any effects.
     
  13. johnwester130

    johnwester130 Member

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    this sounds very expensive to do

    you could save more money with topical applications which stay in the blood longer
     
  14. Arrade

    Arrade Member

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    I am interested in that, I wonder if it would help with hairloss?
    I know haidut sells kuinon. Could you point me to any threads that shows it stays in the blood longer/increased efficacy?
     
  15. johnwester130

    johnwester130 Member

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    in the kuinone thread, it says topical application of mk4 stays in the blood longer, but the solvent is also important to achieve this
     
  16. Arrade

    Arrade Member

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    I'll look into it, thanks :)
     
  17. oceantree

    oceantree Member

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    Interesting thread, recently started taking MK4 and MK7
     
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