• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

Vitamin K, D and A bind to the SARS‐CoV‐2 spike protein

Birdie

Member
Joined
Aug 10, 2012
Messages
3,408
Location
USA
This was really interesting. Here is the abstract:

We investigate binding of linoleate and other potential ligands to the recently discovered fatty acid binding site in the SARS‐CoV‐2 spike protein, using docking and molecular dynamics simulations. Simulations suggest that linoleate and dexamethasone stabilize the locked spike conformation, thus reducing the opportunity for ACE2 interaction.

In contrast, cholesterol may expose the receptor‐binding domain by destabilizing the closed structure, preferentially binding to a different site in the hinge region of the open structure. We docked a library of FDA‐approved drugs to the fatty acid site using an approach that reproduces the structure of the linoleate complex.

Docking identifies steroids (including dexamethasone and vitamin D); retinoids (some known to be active in vitro, and vitamin A); and vitamin K as potential ligands that may stabilize the closed conformation. The SARS‐CoV‐2 spike fatty acid site may bind a diverse array of ligands, including dietary components, and therefore provides a promising target for therapeutics or prophylaxis.

Using dexamethasone type compounds is part of treatment plans used by doctors who treat Covid 19, so this helps give insight for that.
 

Birdie

Member
Joined
Aug 10, 2012
Messages
3,408
Location
USA
The fat‐soluble vitamins D (vitamin D3 metabolite calcitriol), K and A ranked more highly than LA− by BUDE binding energy. Vitamin K2 is the highest ranked compound overall;
 

Birdie

Member
Joined
Aug 10, 2012
Messages
3,408
Location
USA
Maybe a study of some of the more pricy compounds with the Spike Protein will follow. but this simulation is great confirmation.
 

Mauritio

Member
Thread starter
Joined
Feb 26, 2018
Messages
3,297
Maybe a study of some of the more pricy compounds with the Spike Protein will follow. but this simulation is great confirmation.
I'm just not sure how applicable that is for reality and what a good dosage would be.
But I asked Peat what he thinks about that study in relation to vitamin K for covid treatment/vaccines .
 

Grapelander

Member
Joined
Mar 26, 2019
Messages
443
Location
Sonoma County
This study shows that Vitamin K, D, and A very effectively bind to a certain part of the SARS‐CoV‐2 spike protein (fatty acid binding site) .
Through this mechanism it inhibits viral entry, because it blocks binding to the endogenous ACE2 enzyme.
At least this is how I'm reading it, correct me if I'm wrong.

Interestingly vitamin K2 was the most effective out of all the substances they screened! Vitamin D and K were also up there.

"Vitamin K2 is the highest ranked compound overall; vitamin A acetate is ranked 17th; vitamin D (calcitriol) 24th; vitamin A 38th and vitamin K1 70th."

"Furthermore, the implication that, by binding to the spike FA site, fat‐soluble vitamins may stabilize the locked form of the spike and inhibit viral entry suggests that these compounds could also play a more direct role in protecting host cells from viral infection. "

I'll include a list of the 100 most effective substances they found.
Most of the molecules I've never heard of (maybe @haidut knows some of them) ,but a quick google search shows the third most effective is an analog of vitamin D2 and lowers PTH . Squalene is also mentioned.
(Doxercalciferol - Wikipedia)

View attachment 30491View attachment 30490

(Molecular Simulations suggest Vitamins, Retinoids and Steroids as Ligands of the Free Fatty Acid Pocket of the SARS‐CoV‐2 Spike Protein)

Ursolic Acid ranks well on this list:

Ursolic acid is present in many plants, such as Mirabilis jalapa,as well as in many fruits and herbs used in daily life (e.g. apples, basil and holy basil, bilberries, cranberries, elder flower, peppermint, rosemary, lavender, oregano, thyme, hawthorn, and prunes). Apple peels contain large quantities of ursolic acid and related compounds.

In vitro, ursolic acid inhibits the proliferation of various cancer cell types by inhibiting the STAT3 activation pathway, and may also decrease proliferation of cancer cells and induce apoptosis. Ursolic acid has also been shown to inhibit JNK expression and IL-2 activation of JURKAT leukemic T Cells leading to the reduction in proliferation and T cell activation. Ursolic acid is a weak aromatase inhibitor (IC50 = 32 μM), and has been shown to increase the amount of muscle and brown fat and decrease white fat obesity and associated conditions when added to diets fed to mice. Under physiological concentrations, ursolic acid also induces eryptosis (the apoptosis-like suicidal cell death in defective red blood cells). It has been found to reduce muscle atrophy and to stimulate muscular growth in mice, also shows a potential cardioprotection.

In mice, ursolic acid induces neural regeneration after sciatic nerve injury. In mice with chronic multiple sclerosis, ursolic acid has reduced further damage to neurons and helped rebuild the protective sheaths covering neurons, apparently by suppressing Th17 immune cells and activating precursor cells that mature into myelin-sheath-making cells, called oligodendrocytes. Ursolic acid improves domoic acid-induced cognitive deficits in mice. Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice. Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways. Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Ursolic acid enhances mouse liver regeneration after partial hepatectomy. Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin-induced diabetic mice fed a high-fat diet. UA increased skeletal muscle mass, as well as grip strength and exercise capacity. Improved endurance, reduced the expression of the genes involved in the development of muscle atrophy, and decreased indicators of accumulated fatigue and exercise-induced stress.
 

Mauritio

Member
Thread starter
Joined
Feb 26, 2018
Messages
3,297
Here's the email exchange :

Q: Hello Mr. Peat,
Have you seen this study?
It shows vitamin K2 beeing very good at binding to the SARS-cov-2 spike protein.
Molecular Simulations suggest Vitamins, Retinoids and Steroids as Ligands of the Free Fatty Acid Pocket of the SARS‐CoV‐2 Spike Protein

A: I hadn’t seen it, thanks.

Q: You're welcome.
What do you think that means for k2 as a potential treatment for covid and vaccine damage / shedding?

A: Inflammation tends to calcify soft tissues, and K helps to prevent that, so, like vitamin D, it protects at a fundamental level.

Q: Thanks. I'm not sure if you've seen it ,but there is a study showing the spike protein beein able to activate TLR4 independently of its viral action .
So Vitamin D is working on an even more fundamental level, as it also works as a TLR4-antagonist.

SARS-CoV-2 spike protein interacts with and activates TLR41
 

Mr.Bollox

Member
Joined
Mar 16, 2021
Messages
3,187
Here's the email exchange :

Q: Hello Mr. Peat,
Have you seen this study?
It shows vitamin K2 beeing very good at binding to the SARS-cov-2 spike protein.
Molecular Simulations suggest Vitamins, Retinoids and Steroids as Ligands of the Free Fatty Acid Pocket of the SARS‐CoV‐2 Spike Protein

A: I hadn’t seen it, thanks.

Q: You're welcome.
What do you think that means for k2 as a potential treatment for covid and vaccine damage / shedding?

A: Inflammation tends to calcify soft tissues, and K helps to prevent that, so, like vitamin D, it protects at a fundamental level.

Q: Thanks. I'm not sure if you've seen it ,but there is a study showing the spike protein beein able to activate TLR4 independently of its viral action .
So Vitamin D is working on an even more fundamental level, as it also works as a TLR4-antagonist.

SARS-CoV-2 spike protein interacts with and activates TLR41
what else activates TLR4, endotoxin, silica
 
Similar threads
Thread starter Title Forum Replies Date
TypicalJock Does Vitamin E have any contributions to food intolerance? Digestion 0
BearWithMe Vitamin D supps might have shelf life as low as 2 weeks after opening? Ask For Help or Advice 6
Ippodrom47 You CAN get vitamin A toxicity from beta-carotene Scientific Studies 3
L Hypocupremia associated with prior vitamin B12 deficiency Scientific Studies 0
Ippodrom47 Vitamin A and B12 interactions? Ask For Help or Advice 4
B Vitamin D relation with Cholesterol? Ask For Help or Advice 0
Xavage Peaty way to increase Vitamin K without supplementation? Ask For Help or Advice 7
RenaissanceMan Thoughts on Vitamin A Supplementation alongside T3? Ask For Help or Advice 0
Coffe Vitamin D3 and K2 timing Vitamins 6
E Vitamin D Palpitations (I already take magnesium) Ask For Help or Advice 14
IROM Just ordered Progest-Avail, BHRT Topical Pregnenolone in Vitamin E and BHRT Topical DHEA along with bulk Naringin and Chrysin. Supplements 1
A Why does Vitamin E gives me uterine cramps... Supplements, Pharmaceutical Drugs 4
Pina Proteolytic Enzymes vs Vitamin E - Reversing fibrosis and soft tissue calcification Ask For Help or Advice 38
CHEESEHEAD69 Looking for good quality vitamin d3 supplement cheap? Ask For Help or Advice 22
Coffe Time needed for optimum Vitamin D Vitamins 5
G Vitamin K Absolutely Changed My Face (Wow!) Ask For Help or Advice 13
sugarbabe Trouble going off vitamin C Ask For Help or Advice 67
haidut Vitamin D3 anabolic, calcitriol catabolic for muscle/thymus Scientific Studies 4
haidut Vitamin B1 and/or biotin may treat Huntington Disease (HD) Scientific Studies 35
CiggyTardust Vitamin D3 and Calcification D 14
Mauritio 4000 IU of Vitamin D increases Testosterone by 41% Vitamins 63
youngsinatra Anyone here feeling best on high calcium alone without vitamin D? Ask For Help or Advice 8
F Thyroid glandular vs thyroid meds is like comparing orange juice to vitamin C??? Ask For Help or Advice 2
Elize Vitamin patches Metabolism 5
E Anyone tried Vitamin K2 MK-9? Ask For Help or Advice 4
Braveheart More Evidence That Vitamin D Protects Against Severe COVID-19 Disease and Death D 9
haidut Vitamin A may treat anosmia (loss of smell) due to COVID-19 Scientific Studies 8
M Do policosanols and vitamin b1 have any interactions with other nutrients? how does thiamine affect methyl groups, other b vitamins and histamine? Ask For Help or Advice 0
Broken man Ameliorative effect of curcumin and vitamin B6 against lithocholic acid-induced cholestasis and liver injury in mice Scientific Studies 4
G Any drawbacks to dissolving pregnenolone w/o vitamin E Ask For Help or Advice 0
Hans Vitamin D3 and vit C resolved COVID-19 pneumonia in 3 days Scientific Studies 14
A COVID-19 and Vitamin A Ask For Help or Advice 4
Peatogenic Magnesium activates Vitamin D Testimonials 11
jpgio Vitamin E makes me feel alive Supplements, Pharmaceutical Drugs 11
E Vitamin D hypersensitivity Ask For Help or Advice 92
limitless77 Vitamin k2 mk4 vs mk7 and dosage? Supplements, Pharmaceutical Drugs 1
Braveheart The neuroprotective effect of vitamin E on chronic sleep deprivation-induced memory impairment E 0
Braveheart Excess vitamin intake: An unrecognized risk factor for obesity Vitamins 4
Mito Vitamin D and COVID-19 - Chris Masterjohn AHS 2021 D 26
miquelangeles Vitamin K and brain function K 3
haidut Vitamin D, reducing fat oxidation may treat lung fibrosis, COVID-19 Scientific Studies 18
haidut Human study - vitamin B1 safe & effective for preventing & treating Alzheimer Disease (AD) Scientific Studies 32
J Vitamin C I.V Intravenous Protocol Cancer 1
yerrag Good Vitamin E Resources From The Past Being Cancelled: Can We Have a Repository Here? E 105
Hans Should you quit coffee to fix a vitamin B1 deficiency? Articles & Scientific Studies 27
J Think I may have vitamin D toxicity Skin 15
K Quit Vitamin E Cold Turkey? Vitamins 6
Mito Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study K 13
ecstatichamster Report any side effects from vitamin K2 here Supplements, Pharmaceutical Drugs 29
GorillaHead Vitamin A! How does one mitigate the damage of too much ? Ask For Help or Advice 19

Similar threads

Top