I'm just not sure how applicable that is for reality and what a good dosage would be.Maybe a study of some of the more pricy compounds with the Spike Protein will follow. but this simulation is great confirmation.
This study shows that Vitamin K, D, and A very effectively bind to a certain part of the SARS‐CoV‐2 spike protein (fatty acid binding site) .
Through this mechanism it inhibits viral entry, because it blocks binding to the endogenous ACE2 enzyme.
At least this is how I'm reading it, correct me if I'm wrong.
Interestingly vitamin K2 was the most effective out of all the substances they screened! Vitamin D and K were also up there.
"Vitamin K2 is the highest ranked compound overall; vitamin A acetate is ranked 17th; vitamin D (calcitriol) 24th; vitamin A 38th and vitamin K1 70th."
"Furthermore, the implication that, by binding to the spike FA site, fat‐soluble vitamins may stabilize the locked form of the spike and inhibit viral entry suggests that these compounds could also play a more direct role in protecting host cells from viral infection. "
I'll include a list of the 100 most effective substances they found.
Most of the molecules I've never heard of (maybe @haidut knows some of them) ,but a quick google search shows the third most effective is an analog of vitamin D2 and lowers PTH . Squalene is also mentioned.
(Doxercalciferol - Wikipedia)
View attachment 30491View attachment 30490
(Molecular Simulations suggest Vitamins, Retinoids and Steroids as Ligands of the Free Fatty Acid Pocket of the SARS‐CoV‐2 Spike Protein)
what else activates TLR4, endotoxin, silicaHere's the email exchange :
Q: Hello Mr. Peat,
Have you seen this study?
It shows vitamin K2 beeing very good at binding to the SARS-cov-2 spike protein.
Molecular Simulations suggest Vitamins, Retinoids and Steroids as Ligands of the Free Fatty Acid Pocket of the SARS‐CoV‐2 Spike Protein
A: I hadn’t seen it, thanks.
Q: You're welcome.
What do you think that means for k2 as a potential treatment for covid and vaccine damage / shedding?
A: Inflammation tends to calcify soft tissues, and K helps to prevent that, so, like vitamin D, it protects at a fundamental level.
Q: Thanks. I'm not sure if you've seen it ,but there is a study showing the spike protein beein able to activate TLR4 independently of its viral action .
So Vitamin D is working on an even more fundamental level, as it also works as a TLR4-antagonist.
SARS-CoV-2 spike protein interacts with and activates TLR41
|Does Vitamin E have any contributions to food intolerance?||Digestion||0|
|Vitamin D supps might have shelf life as low as 2 weeks after opening?||Ask For Help or Advice||6|
|You CAN get vitamin A toxicity from beta-carotene||Scientific Studies||3|
|L||Hypocupremia associated with prior vitamin B12 deficiency||Scientific Studies||0|
|Vitamin A and B12 interactions?||Ask For Help or Advice||4|
|B||Vitamin D relation with Cholesterol?||Ask For Help or Advice||0|
|Peaty way to increase Vitamin K without supplementation?||Ask For Help or Advice||7|
|Thoughts on Vitamin A Supplementation alongside T3?||Ask For Help or Advice||0|
|Vitamin D3 and K2 timing||Vitamins||6|
|E||Vitamin D Palpitations (I already take magnesium)||Ask For Help or Advice||14|
|Just ordered Progest-Avail, BHRT Topical Pregnenolone in Vitamin E and BHRT Topical DHEA along with bulk Naringin and Chrysin.||Supplements||1|
|A||Why does Vitamin E gives me uterine cramps...||Supplements, Pharmaceutical Drugs||4|
|Proteolytic Enzymes vs Vitamin E - Reversing fibrosis and soft tissue calcification||Ask For Help or Advice||38|
|Looking for good quality vitamin d3 supplement cheap?||Ask For Help or Advice||22|
|Time needed for optimum Vitamin D||Vitamins||5|
|G||Vitamin K Absolutely Changed My Face (Wow!)||Ask For Help or Advice||13|
|Trouble going off vitamin C||Ask For Help or Advice||67|
|Vitamin D3 anabolic, calcitriol catabolic for muscle/thymus||Scientific Studies||4|
|Vitamin B1 and/or biotin may treat Huntington Disease (HD)||Scientific Studies||35|
|Vitamin D3 and Calcification||D||14|
|4000 IU of Vitamin D increases Testosterone by 41%||Vitamins||63|
|Anyone here feeling best on high calcium alone without vitamin D?||Ask For Help or Advice||8|
|F||Thyroid glandular vs thyroid meds is like comparing orange juice to vitamin C???||Ask For Help or Advice||2|
|E||Anyone tried Vitamin K2 MK-9?||Ask For Help or Advice||4|
|More Evidence That Vitamin D Protects Against Severe COVID-19 Disease and Death||D||9|
|Vitamin A may treat anosmia (loss of smell) due to COVID-19||Scientific Studies||8|
|M||Do policosanols and vitamin b1 have any interactions with other nutrients? how does thiamine affect methyl groups, other b vitamins and histamine?||Ask For Help or Advice||0|
|Ameliorative effect of curcumin and vitamin B6 against lithocholic acid-induced cholestasis and liver injury in mice||Scientific Studies||4|
|G||Any drawbacks to dissolving pregnenolone w/o vitamin E||Ask For Help or Advice||0|
|Vitamin D3 and vit C resolved COVID-19 pneumonia in 3 days||Scientific Studies||14|
|A||COVID-19 and Vitamin A||Ask For Help or Advice||4|
|Magnesium activates Vitamin D||Testimonials||11|
|Vitamin E makes me feel alive||Supplements, Pharmaceutical Drugs||11|
|E||Vitamin D hypersensitivity||Ask For Help or Advice||92|
|Vitamin k2 mk4 vs mk7 and dosage?||Supplements, Pharmaceutical Drugs||1|
|The neuroprotective effect of vitamin E on chronic sleep deprivation-induced memory impairment||E||0|
|Excess vitamin intake: An unrecognized risk factor for obesity||Vitamins||4|
|Vitamin D and COVID-19 - Chris Masterjohn AHS 2021||D||26|
|Vitamin K and brain function||K||3|
|Vitamin D, reducing fat oxidation may treat lung fibrosis, COVID-19||Scientific Studies||18|
|Human study - vitamin B1 safe & effective for preventing & treating Alzheimer Disease (AD)||Scientific Studies||32|
|J||Vitamin C I.V Intravenous Protocol||Cancer||1|
|Good Vitamin E Resources From The Past Being Cancelled: Can We Have a Repository Here?||E||105|
|Should you quit coffee to fix a vitamin B1 deficiency?||Articles & Scientific Studies||27|
|J||Think I may have vitamin D toxicity||Skin||15|
|K||Quit Vitamin E Cold Turkey?||Vitamins||6|
|Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study||K||13|
|Report any side effects from vitamin K2 here||Supplements, Pharmaceutical Drugs||29|
|Vitamin A! How does one mitigate the damage of too much ?||Ask For Help or Advice||19|