Follow along with the video below to see how to install our site as a web app on your home screen.
Note: This feature may not be available in some browsers.
Click Here if you want to upgrade your account
If you were able to post but cannot do so now, send an email to admin at raypeatforum dot com and include your username and we will fix that right up for you.
I'm not sure why this would be questionable for a Peat forum...???
Vitamin D is one of the main things Peat pushes for and this study aligns perfectly with what we've known before.
As far as I've seen, he is in favor of D supplements when good sun exposure isn't available.It is? But not over supplements?
Cathelicidin preserves intestinal barrier function in polymicrobial sepsis | Critical Care | Full Text
"Our data suggested that 1alpha, 25-dihydroxyvitamin D3 but not cholecalciferol is a potential therapeutic agent for treating sepsis."
"Furthermore, we assessed the therapeutic use of the active form and the inactive form of VD3 in our CLP model. We observed that administration of calcitriol (an active form of VD3) but not cholecalciferol (an inactive form of VD3) after the onset of sepsis led to a better survival outcome in CLP mice. In line with recent publications, high-dose VD3 (cholecalciferol, inactive form of VD3) did not improve the survival outcomes of critically ill patients in terms of 90-day mortality [50]. Since hepatic cytochrome P450 (CYPs) play an essential role in the conversion of VD3 into 25-hydroxyVD3 together with additional evidence showing that hepatic CYPs dysfunctions are linked to sepsis [51,52,53], we further examined the functions of the liver after the onset of sepsis. Our results demonstrated that CLP induced hepatic damage and the associated downregulations of hepatic CYPs at mRNA level, resulting in decreased serum intermediate and active VD3. Fortunately, the administration of calcitriol (an active form of VD3) can bypass hepatic biotransformation of cholecalciferol into 25-hydroxyVD3 mediated by CYP system, directly entering the circulatory system and exerting the beneficial effects. Taken together, we confirmed that the active form of VD3 but not the inactive form of VD3 is a therapeutic drug in our CLP model. Noticeably, the latter worsened 7-day mortality and the associated symptoms in CLP-operated mice, the mechanism of which remains unclear."
And what Daily Dose when you live in northern countries?