Vitamin C-aspirin Interactions

[Lucenzo01]

Vitamin C-aspirin interactions.
Basu TK. Int J Vitam Nutr Res Suppl. 1982.
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Abstract
The effect of soluble aspirin on the availability of vitamin C has been studied in guinea-pigs and human subjects. In the human study, the concentrations of vitamin C in plasma, leucocytes and urine were found to be markedly elevated at various intervals following administration of a single oral dose of 500 mg of the vitamin. The vitamin C-associated increases, however, appeared to be blocked when the vitamin was given simultaneously with aspirin (900 mg). Similar findings were observed in guinea-pigs, where in addition faecal excretion of vitamin C was found to be significantly increased when the vitamin was administered together with aspirin. These results suggest that aspirin may impede gastrointestinal absorption of vitamin C. This hypothesis has been strengthened with in vitro studies using everted gut sac preparations where both the serosal/mucosal concentration gradient and the uptake of vitamin C per unit weight of intestine were markedly lowered by acetyl-salicylate. Such an interaction is relevant to the population where vitamin C intake is borderline.

 

[Amazoniac]

Gastrointestinal Effects of the Addition of Ascorbic Acid to Aspirin

"While a direct relationship between the presence of ascorbic acid and gastrointestinal damage is not known, there appears to be mechanistic evidence to support the benefit of supplementation with ascorbic acid in the presence of a gastrointestinal irritant such as aspirin.4"

"There is reasonable evidence to support the benefit of the addition of ascorbic acid to aspirin to allay adverse gastrointestinal (GI) effects of aspirin monotherapy. Endoscopic observations in combination with patient reported tolerability and pharmacokinetic data confirm the postulated protective mechanism."

"Ascorbic acid’s demonstrated benefit augments existing options to mitigate the adverse GI of NSAIDs."

"The benefits of ascorbic acid in reference to gastrointestinal tolerability have been discussed here with regard to aspirin. This proposed benefit may extend to the wider class of traditional NSAIDs (eg, naproxen, ibuprofen, and diclofenac) and potentially other medications characteristically associated with poor gastrointestinal tolerability. Further study to verify this effect is warranted."

"The combination of aspirin and ascorbic acid offers a well-tolerated option that is supported by objective and subjective evidence. The improvements in clinical markers of gastrointestinal damage result in a favorable tolerability profile for aspirin plus ascorbic acid. The addition of ascorbic acid to aspirin improves measures of gastrointestinal damage and oxidative stress. These benefits may result in an improved tolerability profile for the aspirin plus ascorbic acid product compared to aspirin alone."

@DaveFoster @ecstatichamster

 

[DaveFoster]

Gastrointestinal Effects of the Addition of Ascorbic Acid to Aspirin

"While a direct relationship between the presence of ascorbic acid and gastrointestinal damage is not known, there appears to be mechanistic evidence to support the benefit of supplementation with ascorbic acid in the presence of a gastrointestinal irritant such as aspirin.4"

"There is reasonable evidence to support the benefit of the addition of ascorbic acid to aspirin to allay adverse gastrointestinal (GI) effects of aspirin monotherapy. Endoscopic observations in combination with patient reported tolerability and pharmacokinetic data confirm the postulated protective mechanism."

View attachment 11435

"Ascorbic acid’s demonstrated benefit augments existing options to mitigate the adverse GI of NSAIDs."

"The benefits of ascorbic acid in reference to gastrointestinal tolerability have been discussed here with regard to aspirin. This proposed benefit may extend to the wider class of traditional NSAIDs (eg, naproxen, ibuprofen, and diclofenac) and potentially other medications characteristically associated with poor gastrointestinal tolerability. Further study to verify this effect is warranted."

"The combination of aspirin and ascorbic acid offers a well-tolerated option that is supported by objective and subjective evidence. The improvements in clinical markers of gastrointestinal damage result in a favorable tolerability profile for aspirin plus ascorbic acid. The addition of ascorbic acid to aspirin improves measures of gastrointestinal damage and oxidative stress. These benefits may result in an improved tolerability profile for the aspirin plus ascorbic acid product compared to aspirin alone."

@DaveFoster @ecstatichamster

Thank you. That's going in my book with an asterisk linking to your profile page on the RP forum.

 

[ecstatichamster]

Aspirin with ascorbic acid, magnesium carbonate, collagen, and niacinamide is my go to aspirin protocol.

 

[Diogo]

Acetylsalicylic acid and ascorbic acid combination improves cognition; via antioxidant effect or increased expression of NMDARs and nAChRs? - PubMed

Chronic inflammation occurs systematically in the central nervous system during ageing, it has been shown that neuroinflammation plays an important role in the pathogenesis of many neurodegenerative disorders. Aspirin, a nonselective COX inhibitor, as well as ascorbic acid, has been purported to...

pubmed.ncbi.nlm.nih.gov

Protective effects of salicylic acid and vitamin C on sulfur dioxide-induced lipid peroxidation in mice - PubMed

The antioxidant effects of exogenous salicylic acid (SA) and vitamin C (Vit C) on the oxidative stress induced by 56 mg/m(3) of sulfur dioxide (SO2) in mouse livers and brains were investigated. The exposure of SO2 caused significant elevation of thiobarbituric acid-reactive substance (TBARS)...

pubmed.ncbi.nlm.nih.gov