Vitamin B6 (P5P) Functions As A PPI

Discussion in 'Scientific Studies' started by haidut, Feb 26, 2015.

  1. haidut

    haidut Member

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    If I am reading this right, P5P acts like a PPI. This would explain some of the protective effects of P5P on stress-induced gastric ulcers in animals and men.

    http://www.jbc.org/content/263/8/3652.long

    "...Pig gastric membrane vesicles enriched in (H++K+)-ATPase were covalently modified with pyridoxal-5'- phosphate (PLP). The modification resulted in inhibition of K+-dependent ATP hydrolysis, formation of phosphoenzyme and ATP-driven H+-uptake catalyzed by (H+ +K+)-ATPase. ATP, ADP, and adenyl-5-ylimidodiphosphate were protective ligands, whereas Mg+ and K+ were not."
     
  2. paymanz

    paymanz Member

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    what is PPI?
     
  3. Philomath

    Philomath Member

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    Proton-pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. They are the most potent inhibitors of acid secretion available.
     
  4. OP
    haidut

    haidut Member

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    PPI = Proton Pump Inhibitor. These are second-generation drugs that block stomach acid production and are used to treat GERD and ulcers.
     
  5. docall18

    docall18 Member

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    So would b6 then have the negative effects of PPI,s. ie lowered stomach acid, cancer causing?
     
  6. Spartan300

    Spartan300 Member

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    Confused..... Most people here battling hypo symptoms, one of which is low stomach acid & P5P is one of the things recommended for hypo?
     
  7. OP
    haidut

    haidut Member

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    The cancer causing effects of PPI are mostly through inhibition of steroid synthesis, and depletion of magnesium and calcium. These all have profound negative systemic effects. The studies with B6 so far found only protective effects against cancer.
     
  8. OP
    haidut

    haidut Member

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    I think in the doses that Peat recommends (5mg daily) it does not have any negative effect on acid production. The study above was meant more as something interesting to think about. Not avoid B6 because it is like a PPI.
     
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