Vitamin B6 For All Inflammatory Conditions And Cancer

[haidut]

It looks like there is a strong push to patent derivatives of P5P for treatment of virtually all types of inflammatory conditions, and prevention of cancer. P5P even has anti-depressant and anti-seizure activities. The mechanism of action is antagonism of the P2X "receptors" and according to the studies P5P is a general and potent antagonist on the entire family of P2X "receptors". Thus, is could be the basis of the new wave of pharma drugs for all inflammatory conditions and cancer.

http://onlinelibrary.wiley.com/doi/10.1002/wmts.1/pdf
http://patentscope.wipo.int/search/en/WO2006136004
http://cdn.intechopen.com/pdfs-wm/24637.pdf
http://jpet.aspetjournals.org/content/295/3/862.long

 

[aguilaroja]

...The mechanism of action is antagonism of the P2X "receptors" and according to the studies P5P is a general and potent antagonist on the entire family of P2X "receptors"....

This recent review is the best listing of some of the P2X7 pathway interests that I have seen:

http://www.ncbi.nlm.nih.gov/pubmed/25223574
Trends Pharmacol Sci. 2014 Oct;35(10):537-547. doi: 10.1016/j.tips.2014.08.002.
P2X7 receptor: an emerging target in central nervous system diseases.
Sperlágh B1, Illes P2.

Abstract
The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a potential drug target because of its widespread involvement in inflammatory diseases as a key regulatory element of the inflammasome complex. However, it has only recently become evident that P2X7Rs also play a pivotal role in central nervous system (CNS) pathology. There is an explosion of data indicating that genetic deletion and pharmacological blockade of P2X7Rs alter responsiveness in animal models of neurological disorders, such as stroke, neurotrauma, epilepsy, neuropathic pain, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, and Huntington's disease. Moreover, recent studies suggest that P2X7Rs regulate the pathophysiology of psychiatric disorders, including mood disorders, implicating P2X7Rs as drug targets in a variety of CNS pathology.

 

[Such_Saturation]

Can you imagine the war they will wage against natural B6?

 

[DrG]

Haidut - Are you making the cancer reduction connection on the general basis of inflammation reduction? Or are there specific studies relevant to cancer?

 

[haidut]

Haidut - Are you making the cancer reduction connection on the general basis of inflammation reduction? Or are there specific studies relevant to cancer?

Both - there are specific studies on B6/P5P and pancreatic cancer as well as several others, and there is also the inflammation factor too. The studies I posted above discuss both aspects - the specific anti-cancer mechanisms and the anti-inflammatory activity.

 

[retroactive]

What would be good dosing for P5P?

 

[ddjd]

It looks like there is a strong push to patent derivatives of P5P for treatment of virtually all types of inflammatory conditions, and prevention of cancer. P5P even has anti-depressant and anti-seizure activities. The mechanism of action is antagonism of the P2X "receptors" and according to the studies P5P is a general and potent antagonist on the entire family of P2X "receptors". Thus, is could be the basis of the new wave of pharma drugs for all inflammatory conditions and cancer.

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WO2006136004 INHIBITION OF ATP-MEDIATED, P2X7 DEPENDENT PATHWAYS BY PYRIDOXAL-5-PHOSPHASTE AND VITAMIN B6 RELATED COMPOUNDS
http://cdn.intechopen.com/pdfs-wm/24637.pdf
P2 Purinergic Receptors: Modulation of Cell Function and Therapeutic Potential

would regular b6 not have the same effect??

not sure about the credibility of this study but its suggesting potential 4x risk of lung cancer from taking daily b6
https://cancer.osu.edu/news/long-te...ted-with-increased-lung-cancer-risk-among-men

 

[orewashin]

would regular b6 not have the same effect??

not sure about the credibility of this study but its suggesting potential 4x risk of lung cancer from taking daily b6
Long-Term, High-Dose Vitamin B6/B12 Use Associated With Increased Lung Cancer Risk Among Men

I imagine that P5P would be enough because we have regular B6 in our diets. Some say B6 makes them feel better, I guess it comes down to how it makes you feel.

 

[Amazoniac]

- Antitumor effect of vitamin B6 and its mechanisms

Epidemiological studies have reported an inverse association between vitamin B6 intake and colon cancer risk. Our recent study has been conducted to examine the effect of dietary vitamin B6 on colon tumorigenesis in mice. Mice were fed diets containing 1, 7, 14 or 36 mg/kg pyridoxine for 22 weeks, and given a weekly injection of azoxymethane (AOM) for the initial 10 weeks. Compared with the 1 mg/kg pyridoxine diet, 7, 14 and 35 mg/kg pyridoxine diets significantly suppressed the incidence and number of colon tumors, colon cell proliferation and expressions of c-myc and c-fos proteins. Supplemental vitamin B6 lowered the levels of colonic 8-hydroxyguanosine (8-OHdG), 4-hydroxy-2-nonenal (4-HNE, oxidative stress markers) and inducible nitric oxide (NO) synthase protein. In an ex vivo serum-free matrix culture model using rat aortic ring, supplemental pyridoxine and pyridoxal 5′-phosphate (PLP) had antiangiogenic effect. The results suggest that dietary vitamin B6 suppresses colon tumorigenesis by reducing cell proliferation, oxidative stress, NO production and angiogenesis.