Vitamin B6 deficiency promotes PUFA accumulation in tissues

[haidut]

So, make sure you ingest enough vitamin B6 while working to deplete PUFA stores.

http://www.ncbi.nlm.nih.gov/pubmed/6481472

"...In -PN rats, phospholipid levels of linoleic and gamma-linolenic acids were increased, but arachidonic acid was decreased compared to controls in plasma, liver, thymus and skin. In liver triglycerides from -PN rats, all essential fatty acids (n3 and n6) were increased compared to both control and +PN rats. The n3 essential fatty acids were significantly increased in plasma, liver, and thymus phospholipids in the +PN compared to control rats. These results support previous reports of an effect of pyridoxine on essential fatty acid metabolism and suggest that both linoleic desaturation and gamma-linolenic acid elongation may be impaired in -PN rats. In addition, the accumulation of essential fatty acids in the liver triglycerides of -PN rats suggests that essential fatty acid turnover between triglyceride and phospholipid may be influenced by pyridoxine."

 

[GorillaHead]

How interesting. Here we see b6 deficiency Results in lower Pufa in serum and higher omega 6 to omega 3 ratio in humans.

Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women - PubMed

Previous animal studies showed that severe vitamin B-6 deficiency altered fatty acid profiles of tissue lipids, often with an increase of linoleic acid and a decrease of arachidonic acid. However, little is known about the extent to which vitamin B-6 deficiency affects human fatty acid profiles...

pubmed.ncbi.nlm.nih.gov

so it seems when b6 is low the body places Pufa in tissue.

 

[GorillaHead]

So Pufa in tissues bad. Pufa in blood good ?

 

[Riesensackteil]

So Pufa in tissues bad. Pufa in blood good ?

PUFA in blood would act (be) Free Fatty Acids then

 

[Dr. B]

So, make sure you ingest enough vitamin B6 while working to deplete PUFA stores.

Accumulation of linoleic and gamma-linolenic acids in tissue lipids of pyridoxine-deficient rats - PubMed

"...In -PN rats, phospholipid levels of linoleic and gamma-linolenic acids were increased, but arachidonic acid was decreased compared to controls in plasma, liver, thymus and skin. In liver triglycerides from -PN rats, all essential fatty acids (n3 and n6) were increased compared to both control and +PN rats. The n3 essential fatty acids were significantly increased in plasma, liver, and thymus phospholipids in the +PN compared to control rats. These results support previous reports of an effect of pyridoxine on essential fatty acid metabolism and suggest that both linoleic desaturation and gamma-linolenic acid elongation may be impaired in -PN rats. In addition, the accumulation of essential fatty acids in the liver triglycerides of -PN rats suggests that essential fatty acid turnover between triglyceride and phospholipid may be influenced by pyridoxine."

Doesnt B6 increase arachidonic acid production and was why those essential fatty acid deficient acid rats symptoms improved when given supplements of zinc and b6 I believe?
Also I thought b6 also increases serotonin or conversion to serotonin