Vitamin B6 deficiency promotes PUFA accumulation in tissues


Mar 18, 2013
USA / Europe
So, make sure you ingest enough vitamin B6 while working to deplete PUFA stores.

"...In -PN rats, phospholipid levels of linoleic and gamma-linolenic acids were increased, but arachidonic acid was decreased compared to controls in plasma, liver, thymus and skin. In liver triglycerides from -PN rats, all essential fatty acids (n3 and n6) were increased compared to both control and +PN rats. The n3 essential fatty acids were significantly increased in plasma, liver, and thymus phospholipids in the +PN compared to control rats. These results support previous reports of an effect of pyridoxine on essential fatty acid metabolism and suggest that both linoleic desaturation and gamma-linolenic acid elongation may be impaired in -PN rats. In addition, the accumulation of essential fatty acids in the liver triglycerides of -PN rats suggests that essential fatty acid turnover between triglyceride and phospholipid may be influenced by pyridoxine."


Oct 21, 2018
How interesting. Here we see b6 deficiency Results in lower Pufa in serum and higher omega 6 to omega 3 ratio in humans.

so it seems when b6 is low the body places Pufa in tissue.
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