Vitamin B3 Modulates Mitochondrial Vulnerability And Prevents Glaucoma In Aged Mice

Discussion in 'Articles & Scientific Studies' started by paymanz, Jul 24, 2017.

  1. paymanz

    paymanz Member

    Jan 6, 2015
    Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. - PubMed - NCBI

    Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly. The mechanisms initiating glaucoma and driving neuronal vulnerability during normal aging are unknown. Studying glaucoma-prone mice, we show that mitochondrial abnormalities are an early driver of neuronal dysfunction, occurring before detectable degeneration. Retinal levels of nicotinamide adenine dinucleotide (NAD+, a key molecule in energand redox metabolism) decrease with age and render aging neurons vulnerable to disease-related insults. Oral administration of the NAD+ precursor nicotinamide (vitamin B3), and/or gene therapy (driving expression of Nmnat1, a key NAD+-producing enzyme), was protective both prophylactically and as an intervention. At the highest dose tested, 93% of eyes did not develop glaucoma. This supports therapeutic use of vitamin B3 in glaucoma and potentially other age-related neurodegenerations.