Amazoniac
Member
A person can eat more than 50000IU from diet in a week, which exceeds that value, and from retinol alone. Perhaps greater amounts given at once allows a better regulation of its metabolism compared to chronic smaller daily doses. Regardless of clear toxicity, ingesting more than what's needed must demand extra stabilization since they're all unsaturated and vulnerable to damage, especially if they're not being put to good use. Can you view my thoughts as Lego and assemble them in a way that I can think properly and then take a picture and post on your instagram with the title "Work-in-progress" if you have any further comments?I just read that the chronic toxic dose was only 4,000 IU.
At a dose like this, you expect the majority to be stored safely in the liver as retinol esters. However, the liver will become saturated someday. When the storage capacity is exceeded than it may become a problem.
The tissue retinoic acid concentrations are dependent on the blood retinol concentrations. High retinoic acid levels increase transcription of hundreds of genes involved in cell growth. Topical retinoic acid can double the skin turnover rate, and high chronic fish oil consumption in The Nordic Countries is associated with osteoporosis consequent of increased alkaline phosphatase transcription. But this could be potentiated by the relatively low vitamin D photosynthesized in the Northern latitudes.
If you want to know exactly what happens to the cell with increased retinol, you have to look at an mRNA microarray study. This is where they extract all of the mRNA and characterize it; match it to the proteins they transcribe.
Shouldn't be an issue if your liver isn't saturated.
You might expect skin changes with even one high dose. If you exceed the storage rate of the liver, you would expect the blood level to rise. But your liver would then pull-out retinol from the bloodstream (HDL) and store it, so the increase would be short-lived. I think the only real problem is by totally saturating the liver, and this would take time. But there is certainly no way to know how much retinol esters are already stored in the liver before supplementation. A person on a hardcore paleoatkins diet might already be ~70% saturated.
Ps.: I used to use retinoic acid creams and I can tell up to this day the places that I used more of it, since the region still has a faster turn over. It's crazy how lingering the effects are.
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