kineticz
Member
Some estrogen is good. While it stimulates ACTH, it increases receptor sensitivity to cortisol and thyroid. Nobody wants desensitized receptors.
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Some estrogen is good. While it stimulates ACTH, it increases receptor sensitivity to cortisol and thyroid. Nobody wants desensitized receptors.
Some estrogen is good. While it stimulates ACTH, it increases receptor sensitivity to cortisol and thyroid. Nobody wants desensitized receptors.
It also desensitizes the pituitary to cortisol so it will keep producing ACTH even when adrenals are pumping out ton of cortisol. Estrogen, beyond a certain level, is a great way to get Cushing syndrome or "autoimmune", or immunodeficiency condition. It can activate retroviruses inside you that can kill a person in a week if immune system is not working well, which it won't be since cortisol is also high.
So yeah, some is probably fine but chronically speaking the lower the better.
You're absolutely right. I have experienced this.
I had estrogen dominance after consuming oral DHEA. At a certain point, the effect on neurotransmitter and stress tolerance was bliss. After that, the rounded cushings face and high levels of anxiety hit, followed by an adrenal crash.
I then had no estrogen for quite some time, which made it difficult to treat the adrenals. That was until I realised that in calcified kidneys, vitamin D goes down, which is the precursor to DHEA.
But I still feel there is an appropriate level of E2, for example 20, as estrogen is important for the proper recycling of iron and copper, ceruloplasmin, acetylcoA and heme.
Now by raising my vitamin D my DHEA seems to go directly into DHT.
Did you know the 17-20 lyase enzyme is stimulated by l-serine, also found in the kidneys? Nobody ever seems to recommend this amino acid for treating low DHEA. It works for me.
Thanks for the info on serine. I did know of that property of serine, but glycine and taurine are known to do the same and given that serine is synthesized from glycine that property does not surprise me.
How much vitamin D were you taking and for how long? Were you aiming for a specific blood level that optimizes DHT production from DHEA?