In theory, anything that reduces prolactin will likely also reduce estrogen and vice versa. So, since vitamin A is anti-estrogenic I wondered if there is evidence that vitamin A will lower prolactin and/or increase dopamine. Below is some evidence that vitamin A is indeed dopaminergic and lowers prolactin. The human dose was about 100,000 IU per day or pre-formed all-trans retinoic acid.
Given the human study showing significant fall in prolactin from 300mg vitamin E daily, this likely makes the vitamin A + vitamin E combo a viable option for people wanting to reduce prolactin / estrogen.
1. Human study
http://www.ncbi.nlm.nih.gov/pubmed/16483172
"...Moreover, acitretin treatment induced a significant reduction of PRL levels after 3 months (from 182 +/- 70 to 150 +/- 56 mU/l, p < 0.05). During treatment, no change in TSH and PRL response either to TRH or dopamine infusion was observed. In conclusion, we demonstrated that treatment with low dose of acitretin induced a series of hormonal modifications that, in addition to a mild and transient reduction of TSH levels, included a persistent reduction of FT3, probably due to changes in thyroid hormone metabolism, and a decrease in PRL levels."
2. Animal and in vitro studies
http://www.ncbi.nlm.nih.gov/pubmed/21600965
http://www.ncbi.nlm.nih.gov/pubmed/18367633
http://www.ncbi.nlm.nih.gov/pubmed/9884583
http://www.ncbi.nlm.nih.gov/pubmed/9405615
http://www.ncbi.nlm.nih.gov/pubmed/9721718
http://www.ncbi.nlm.nih.gov/pubmed/9452386
http://www.ncbi.nlm.nih.gov/pubmed/23040108
http://www.sciencedirect.com/science/ar ... 1505000980
Given the human study showing significant fall in prolactin from 300mg vitamin E daily, this likely makes the vitamin A + vitamin E combo a viable option for people wanting to reduce prolactin / estrogen.
1. Human study
http://www.ncbi.nlm.nih.gov/pubmed/16483172
"...Moreover, acitretin treatment induced a significant reduction of PRL levels after 3 months (from 182 +/- 70 to 150 +/- 56 mU/l, p < 0.05). During treatment, no change in TSH and PRL response either to TRH or dopamine infusion was observed. In conclusion, we demonstrated that treatment with low dose of acitretin induced a series of hormonal modifications that, in addition to a mild and transient reduction of TSH levels, included a persistent reduction of FT3, probably due to changes in thyroid hormone metabolism, and a decrease in PRL levels."
2. Animal and in vitro studies
http://www.ncbi.nlm.nih.gov/pubmed/21600965
http://www.ncbi.nlm.nih.gov/pubmed/18367633
http://www.ncbi.nlm.nih.gov/pubmed/9884583
http://www.ncbi.nlm.nih.gov/pubmed/9405615
http://www.ncbi.nlm.nih.gov/pubmed/9721718
http://www.ncbi.nlm.nih.gov/pubmed/9452386
http://www.ncbi.nlm.nih.gov/pubmed/23040108
http://www.sciencedirect.com/science/ar ... 1505000980