Vitamin A Forms Gradients In Embryo And Conveys Information Across Long Distances

Joined
Nov 26, 2013
Messages
7,367
http://www.nature.com/nature/journal/v496/n7445/full/nature12037.html

Complex Regulation of cyp26a1 Creates a Robust Retinoic Acid Gradient in the Zebrafish Embryo

Retinoic acid is a signaling molecule that plays an important role in the development of the brain in animal embryos. It forms a gradient along the body of the embryo from the head end to the tail end, but it has proved difficult to measure this gradient directly. The experiments show that retinoic acid forms a gradient in the embryos, with high levels at the tail end and lower levels at the head end. Retinoic acid can directly convey graded positional information over long distances.

More than 100 years ago the idea of a morphogenetic field was proposed by A.G. Gurwitsch, as a way to explain the orderly movements of cells in embryos and growing tissues, and to understand the principles that cause cells to change appropriately when their location in the organism changes. For 30 years, the concept guided research in embryology, but also led to important discoveries in the biology of cancer, aging, wound repair, and other important areas. But by the late 1940s, a more abstract approach to biology, based on the gene doctrine of Mendel and Weismann, took charge of academic and governmental biological research. This ideology at first said that organisms are determined by unchanging units of inheritance, "genes," and later when genes were found to be susceptible to mutation, the changes were said to be always random. The Central Dogma of the ideology was that any meaningful, adaptive changes that occur in an organism can't influence the genes. For many years, adaptive changes were said to be nothing but changes in the size or function of existing cells, because the cells of the major organs of the body were supposed to be created before birth, or in infancy.
 
Last edited:

Such_Saturation

Member
Thread starter
Joined
Nov 26, 2013
Messages
7,367
I'm doing my assignment with the description :arghh::singing:
 

tara

Member
Joined
Mar 29, 2014
Messages
10,352
Does this imply that one might get different results from applying vit-A supplements transdermally via the feet compared with via the chest or forehead?
Anyone notice a difference depending on where?

I think Peat said he got headaches if he applied vit-A anywhere on his face or neck, probably because he got a tiny bit on his lips. Maybe it was being applied at a disruptive place in the head to toe (tail) gradient?

I'm doing my assignment with the description :arghh::singing:
Sounds like you are getting to do an interesting course.
 

tara

Member
Joined
Mar 29, 2014
Messages
10,352

Such_Saturation

Member
Thread starter
Joined
Nov 26, 2013
Messages
7,367
I do want to try this vitamin A on the feet though :shock: who knows...
 

tara

Member
Joined
Mar 29, 2014
Messages
10,352

dookie

Member
Joined
May 5, 2015
Messages
517
I think Peat said he got headaches if he applied vit-A anywhere on his face or neck, probably because he got a tiny bit on his lips. Maybe it was being applied at a disruptive place in the head to toe (tail) gradient?

Where did he say this? Can you please provide the quote?

I only remember him saying that he would get headaches if it reached his lips, obviously because a small amount would then be swallowed, and it has an allergenic effect on him. I doubt the gradient thing
 

tara

Member
Joined
Mar 29, 2014
Messages
10,352
I doubt the gradient thing
Fair enough, it's a long shot speculation on my part. The OP post talks about the retinoic acid gradient having an effect in the animal embryos, not in full grown humans, and nothing so specific as headache symptoms. Yes, he's referred to it touching his lips and the headaches being allergy reactions.

This quote from Peat refers to him using it on his feet:

I have had bad headaches when I used vitamin A orally, and even getting a little on my lips was enough to do it. It could be that the Nutrisorb-A was the cause, if you used it orally. I use it only on my legs and feet.

This was the Peat quote I was thinking of, refers to getting it on face and arms, not neck, and as you say, he considered it an allergic reaction to some manufacturing contaminant:
In my own migraine experience, I found that a very small amount of either vitamin A or magnesium chloride could cause big headaches for two or three days. If I had put vitamin A anywhere on my face or arms, enough would touch my lips to cause the headache. It wasn't the vitamin A or magnesium itself that did it, but some very powerful allergen in the chemically manufactured products.
 
Similar threads
Thread starter Title Forum Replies Date
D Podcast with Jim Stephenson Jr. on vitamin/hormone D Supplements, Pharmaceutical Drugs 1
T Experiences with Jarrow Formulas vitamin D3 2500 IU? Ask For Help or Advice 0
GorillaHead Vitamin B5 supplementation may cause adrenal over activity? Ask For Help or Advice 1
Doludolu Very LOW Iron , Sufficient Ferritin, Excesivelly high vitamin B12 - Anemia or what is going on? Blood Work, Labs 2
T Now Foods Vitamin E 400 mixed tocopherols experiences and reviews Ask For Help or Advice 2
T Will Thorne research liquid vitamin K2 absorb through the skin? Ask For Help or Advice 8
bzmazu More vitamin K2, more testosterone K 0
ddjd High vitamin D levels essential for tolerating T3?? Ask For Help or Advice 0
L Best vitamin c for a child? Ask For Help or Advice 6
Mito The Great Vitamin D Debate with Georgi Dinkov, Danny Roddy, Kate Deering & Matt Blackburn D 40
M Does a lot of copper increase the need of vitamin C? Ask For Help or Advice 10
Mauritio Vitamin B1 / Thiamine deficiency increases serotonin in the brain Scientific Studies 24
P Study: Vitamin A theory of vaccine injury Scientific Studies 26
haidut Vitamin D can force cancer cells to differentiate back into normal Scientific Studies 1
haidut Oral testosterone + vitamin E may treat NAFLD, NASH, cirrhosis in humans Scientific Studies 6
haidut Glucose + vitamin B3 combo synergistic for treating mitochondrial disease Scientific Studies 1
haidut Nine out of ten COVID-19 deaths may be due to vitamin D deficiency Scientific Studies 22
S Vitamin E overuse? Ask For Help or Advice 9
K Why does vitamin K2 mk4 make my skin dry? K 4
B Tissue concentrations of Menaquinone-4 (Vitamin K2 MK-4) Scientific Studies 0
youngsinatra Can High Vitamin D Compensate Lower Dietary Calcium? Ask For Help or Advice 4
A Does vitamin K supplementation deplete vitamin E? Vitamins 25
youngsinatra Vitamin D - Don‘t Guess, But Test! Ask For Help or Advice 30
cjm "Vitamin E inhibits the activation of NF‐kB, with the greatest inhibition seen with the succinate form." Scientific Studies 2
Pina Kale Water Vitamin K Content Diet 1
youngsinatra Post Your Experience With Topical Vitamin A Here Metabolism 18
M Do vitamin A supplements deplete vitamin A? Ask For Help or Advice 5
Jon2547 Koncentrated K brand of Vitamin K Vitamins 12
M B-Complex or Bee Pollen supplement? Vitamin A supplement or Cod liver oil? Ask For Help or Advice 3
M Best Vitamin A and Copper supplements? Ask For Help or Advice 38
P High dose vitamin k2 around 45mg makes vericocele vanish Male Issues 7
M Does cooking vegetables destroy their vitamin C? Ask For Help or Advice 11
Ras Vitamin C neutralizes chlorine in water C 1
Quelsatron A very confusing month? (vitamin D, magnesium, liver) Ask For Help or Advice 33
Mauritio Vitamin E succinate decreases melanoma size by 650% in vivo Scientific Studies 42
charlie Vitamin B1 in critically ill patients: needs and challenges Scientific Studies 53
C Vitamin D, daily low dose or infrequent high dose? Vitamins 11
G How relevant are serum vitamin tests? Vitamins 11
D Vitamin D Always High! Blood Work, Labs 13
Q Is Vitamin D induced serotonin syndrome possible? Please hear me out... Ask For Help or Advice 60
T VItamin D Megadose accident, what to do Supplements, Pharmaceutical Drugs 6
N Home made vitamin D... Supplements, Pharmaceutical Drugs 1
bzmazu Why politicians and doctors keep ignoring the medical research on Vitamin D and Covid Rant or Rave 2
S I think vitamin K2 ruined my life. Vitamins 76
S Fluorescent pee after b vitamin supp, Normal?! Ask For Help or Advice 15
Hirri Suddenly lower Vitamin D question Vitamins 9
Pistachio Vitamin K2's effect on Lunulae (fingernail crescents) Supplements, Pharmaceutical Drugs 0
Ras How can Vitamin K2 MK-4 be Price's Activator X? K 10
R Interesting podcast on dangers of vitamin E supplementation E 2
Mauritio Cistanche more effective at decreasing lipid peroxidation and free radicals than Vitamin E and Caffeine Science 46

Similar threads

Top