Vit-A receptor STAR6 involved in Covid

LeeLemonoil

Member
Joined
Sep 24, 2016
Messages
4,265
Interesting Preprint @haidut

Read also how mainstream science seems to finally adopt in a way Peat‘s stance about „receptors“ - now they just write that proteins like StaR are „both receptors“ and Membrane components that can take up all kinds of things -

Anyway Vitamin A and derivates are not surprisingly involved in how a Cov-infection plays out, it’s a crucial endocrine and immune Modulator and even facilitates epigenetic rapid changes


Although, the ACE2 receptor has been demonstrated to be the main entry receptor of COVID-19, but our docking analysis , predicted and discovered a novel receptor termed STRA6 that may play a critical role in the pathogenicity of COVID-19 and explain the common pre and post COVID-19 symptoms with unknown etiology. STRA6 receptor expressed in many organs and immune cells, upregulated by retinoic acid jm6 (STRA6) was the first protein to be identified in a novel category of proteins, cytokine signaling transporters, due to its ability to function as both a cell surface receptor and a membrane protein that binds to retinol binding protein facilitating cellular uptake of retinol. The primary ligand of STRA6 (vitamin/retinol) was shown to be drastically reduced during COVID-19 infection, which agrees with our findings
 
OP
L

LeeLemonoil

Member
Joined
Sep 24, 2016
Messages
4,265
I presume a pathomechmanism and alleviating effect of Vit A similsr as in acne and hairloss.
Cov-infection causes among others high nlrp3 activation and activity and estrogens are reacting to downturn nlrp3 but that balance gets dysfunctional and excessive estrogen signaling and action sets in motion deranged hyperinflammation.

Vit A and RA can remodulate excessive estrogen action (as can Vit D, the other secosteroid)
 

JohnHafterson

Member
Joined
Apr 5, 2016
Messages
288
Location
Chicago
Interesting article.

I find it interesting how basic and profound the implications of NLRP3 are and how many substances discussed in forum have such a favorable inhibitory impact.

Thiamine/benfotiamine, B6, methylene blue, aspirin, glycine, Vitamin E, Vitamin D, magnesium, taurine, etc.

Energy -> Structure -> Function

NLRP3 drives RAAS over activation.

"Both renin-angiotensin-aldosterone system (RAAS) and complement cascade are involved in SARS-CoV-2-induced overproduction of inflammatory cytokines (Mahmudpour et al., 2020), and this overproduction is caused by NLRP3 inflammasome (Ratajczak and Kucia, 2020). Besides, the ATP released by pyroptosis-related inflammatory cells also influences the activation of NLRP3 inflammasome via ATP-P2X7R pathway."


Energy important but there are genetic components to the virus/host interaction like ACE2 single nucleotide polymorphism, human leukocyte antigen (HLA) polymorphisms, ABO blood group glycoprotein differences, which impact host susceptibility, etc.

But these substances and Peat in general can pickup the slack of genetic Achilles heels
 
OP
L

LeeLemonoil

Member
Joined
Sep 24, 2016
Messages
4,265
@JohnHafterson

Nlrp3 to me seems to be a very old conserved pathway probably originally activated by microbes but now intertwined with everything.
In my personal view of physiology it very substantively influences the immune roles and effects of the sex-steroids.
That’s why it fits so well with Peats basic stacks of keeping in check hyperestrogenism. When nlrp3 fires full throttle estrogens do too and then inflammation derangement follows
 

GorillaHead

Member
Joined
Oct 21, 2018
Messages
2,372
Location
USA
Isnt there research to show retinol dampened the symptoms of covid. ? Something like that?
 
OP
L

LeeLemonoil

Member
Joined
Sep 24, 2016
Messages
4,265

 

Similar threads

Back
Top Bottom