Using Vitamins (pyridoxine) For Improving Glucose Control

[haidut]

This post is on vitamin B6 (pyridoxine, or pyridoxal-5-phosphate). This vitamin has a long history of administration in diabetes and hyperglycemic conditions. It is especially effective in combination with vitamin B1 (thiamine), vitamin B2 (riboflavin) and vitamin B7 (biotin). Vitamin B6 doses are in the range of 30mg-1,200mg daily depending on the goal. Glycemic control is improved at the lower doses while the higher ones are used for treating diabetic complications.

1. Pyridoxine / P5P review
http://www.ncbi.nlm.nih.gov/pubmed/19643063

2. Human studies
http://www.ncbi.nlm.nih.gov/pubmed/23392542
http://www.ncbi.nlm.nih.gov/pubmed/22231921
http://www.ncbi.nlm.nih.gov/pubmed/6862730
http://www.ncbi.nlm.nih.gov/pubmed/443288
http://www.ncbi.nlm.nih.gov/pubmed/21349613

http://www.ncbi.nlm.nih.gov/pubmed/1131652
"...All patients were treated with vitamin B6 (pyridoxine) 100 mg/day for 14 days by mouth, after which the pyridoxine deficiency disappeared and the oral glucose tolerance improved considerably. Only two patients then had sufficiently impaired glucose tolerance to justify the diagnosis of gestational diabetes."

http://www.ncbi.nlm.nih.gov/pubmed/11165869
"...Both P 9oyridoxine) and PM (pyridoxamine) significantly lowered lipid peroxidation and glycated hemoglobin (HbA(1)) formation in high glucose-exposed RBC. P and PM significantly prevented the reduction in (Na+ + K+)-ATPase activity in high glucose-treated RBC. Thus, P or PM can inhibit oxygen radical production, which in turn prevents the lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction induced by the hyperglycemia. This study describes a new biochemical mechanism by which P or PM supplementation may delay or inhibit the development of complications in diabetes."

http://www.ncbi.nlm.nih.gov/pubmed/21034273
"...Pyridoxine, at dosages known to be safe from previous studies (<250 mg/day) can restore migratory ability and shear stress response to endothelial cells cultured in high-glucose conditions. This indicates that pyridoxine is a potential candidate for treatment of diabetic ulcers and atherosclerosis in diabetes due to the link between these pathologies and endothelial dysfunction in diabetes."


3. Animal studies
http://www.ncbi.nlm.nih.gov/pubmed/23001013
http://www.ncbi.nlm.nih.gov/pubmed/9729446
http://www.ncbi.nlm.nih.gov/pubmed/1919802
http://www.ncbi.nlm.nih.gov/pubmed/21464101

 

[freyasam]

Wow, haidut, thanks so much for putting these B vitamin threads together.

I have tried taking P5P before, but I was led to believe to not go above 10 mg doses. I wonder if I should give it another shot at higher doses, since some of the studies you post here use pretty high amounts.

Thanks again!

 

[haidut]

Wow, haidut, thanks so much for putting these B vitamin threads together.

I have tried taking P5P before, but I was led to believe to not go above 10 mg doses. I wonder if I should give it another shot at higher doses, since some of the studies you post here use pretty high amounts.

Thanks again!

You can try increasing doses starting at 10mg and stop when you don't get any more benefit. Some people react to even low doses. If you have a way of measuring blood glucose, you can try a glucose load test with and without B6.

 

[bdawg]

You can try increasing doses starting at 10mg and stop when you don't get any more benefit. Some people react to even low doses. If you have a way of measuring blood glucose, you can try a glucose load test with and without B6.

Haidut do you know why pyridoxine and pyroxidal have opposite effects on 5ar?

 

[Steene]

Two week ago I orderer sublingual 15 mg P5P. After the second dosage I had an extreme dopamine response I could not sleep the WHOLE night because I wanted to do things and was totally hyped. This wasn't my intention but that happens when you start to even out a deficiency. Now the dopamine response ranges from mild to medium but still noticable. Pyridoxine is very important for everyone who is eating a lot of protein because it gets depleted so fast and most food has so little in it so you rarely get out of a deficiency.

 

[haidut]

Haidut do you know why pyridoxine and pyroxidal have opposite effects on 5ar?

In vivo, neither one has been shown to affect 5-AR and/or steroids derived through that enzyme. I think the in vitro studies used large doses which are hard to achieve in real life without toxicity.

 

[bdawg]

In vivo, neither one has been shown to affect 5-AR and/or steroids derived through that enzyme. I think the in vitro studies used large doses which are hard to achieve in real life without toxicity.

makes sense - also i noticed that they seem to test a lot using injections to the brain which seem like a traumatic way to introduce a chemical/nutrient