UPDATE: Erectile Dysunfction 19y/o (Labs, Low T, High Prolactin, Thyroid Etc)

[x-ray peat]

You have severe hypocholesterolemia (low cholesterol) and a severely crappy doctor to not diagnose that. As mentioned above your testosterone levels will never be normal or your ED fixed if you dont get your cholesterol levels up first and to do that you have to figure out what is causing it.

Hypolipidemia: A Word of Caution

there is no consensus about the level below which a clinically significant hypocholesterolemia will ensue, and each author used a different cut-off value. Even so, most of the authors use a cut-off value between 120 mg/dl (3.1 mmol/l) and 150m/dl (3.88mmol/l) [2,3,4,5]. However some authors use higher levels up to 190mg/dl (4.9mmol/l) [6, 7] while others use lower values such as 100mg/dl (2.59 mmol/l) [8,9,10].

Table I
Causes of hypolipidemia

Primary disorders
Abetalipoproteinemia
Hypobetalipoproteinemia
Chylomicron retention disease
Secondary disorders
Infection (acute or chronic)
Malabsorption and undernutrition
Anemia
Chronic inflammation
Critical illnesses
Malignancies
Hyperthyroidism
Chronic liver disease
Gaucher disease
Drug induced: statins

 

[Deadpool]

You have severe hypocholesterolemia (low cholesterol) and a severely crappy doctor to not diagnose that. As mentioned above your testosterone levels will never be normal or your ED fixed if you dont get your cholesterol levels up first and to do that you have to figure out what is causing it.

Hypolipidemia: A Word of Caution

there is no consensus about the level below which a clinically significant hypocholesterolemia will ensue, and each author used a different cut-off value. Even so, most of the authors use a cut-off value between 120 mg/dl (3.1 mmol/l) and 150m/dl (3.88mmol/l) [2,3,4,5]. However some authors use higher levels up to 190mg/dl (4.9mmol/l) [6, 7] while others use lower values such as 100mg/dl (2.59 mmol/l) [8,9,10].

Table I
Causes of hypolipidemia

Primary disorders
Abetalipoproteinemia
Hypobetalipoproteinemia
Chylomicron retention disease
Secondary disorders
Infection (acute or chronic)
Malabsorption and undernutrition
Anemia
Chronic inflammation
Critical illnesses
Malignancies
Hyperthyroidism
Chronic liver disease
Gaucher disease
Drug induced: statins

What is the cause for this and how do I fix it? I always eat good saturated fat in my diet. HIgh-fat diet, or medium fat diet, low PUFA high saturated fat diets, all of these don't make a difference.

 

[Mauritio]

I supplement with a good high-dose vitamin b6 supplement most of the days.

I agree. you should alsways take a b complex with it. i myself didnt do it and ended up with vitamin b2 deficiency.

 

[x-ray peat]

What is the cause for this and how do I fix it? I always eat good saturated fat in my diet. HIgh-fat diet, or medium fat diet, low PUFA high saturated fat diets, all of these don't make a difference.

From that paper it seems there are a number of possible reasons but it seems obvious that you are well below all of the cutoffs for normal cholesterol levels.

Looking at your T3 and T4 you are also on the extreme high end of the normal range for both. Hyperthyroidism may be whats causing this.

 

[Deadpool]

From that paper it seems there are a number of possible reasons but it seems obvious that you are well below all of the cutoffs for normal cholesterol levels.

Looking at your T3 and T4 you are also on the extreme high end of the normal range for both. Hyperthyroidism may be whats causing this.

Well, doesn't this mean, Peat's diet is actually counter productive for me because I am leaning more towards hyper than hypo?

 

[x-ray peat]

Well, doesn't this mean, Peat's diet is actually counter productive for me because I am leaning more towards hyper than hypo?

Some parts of it would be. I would do a whole lot of research on hypolipidemia and try and figure out what is the root cause. To see if you are really hyperthyroid you could start with checking your morning waking temps and heart rate. I cant say that you are hyperthyroid because your levels though high are still within normal ranges. However your lipid profile is off the charts low so I would start there. I would also mention this to your doctor while giving him the cutoffs for normal level. If he is not helpful you would be best to find a new doctor.

 

[vulture]

Cool language bro. I used to be a skinny b**** but now I am close to 200 pounds with pretty low body fat. I used to "eat like a ******* man" in the past, lots of meat, eggs, milk, the whole game. Did nothing. Now with Peat, drinking lots of milk, orange juice, meat etc, I get some improvements but still nothing. It's cool that you try to shove that bull**** dogma on me, and it would've worked when I was 15, and it actually did, but still, no matter if I eat 3000 or 5000 calories "like a ******* man", my body doesn't utilize.

Have you eaten such amounts of calories Peating? if it doesn't work, then I could start seriously thinking in supplements, checking for any sickness and hormones.

I thought, wrongly, that you were undereating and skinny and hoping to have T of a healthy and prosperous organism. That's a common mistake at that age.

 

[Deadpool]

Have you eaten such amounts of calories Peating? if it doesn't work, then I could start seriously thinking in supplements, checking for any sickness and hormones.

I thought, wrongly, that you were undereating and skinny and hoping to have T of a healthy and prosperous organism. That's a common mistake at that age.

It's all cool, I definitely have, especially the past weeks I seriously upped my calories. It just hit me out of nowhere that I have low cholesterol though, because I eat a ton of fat, and I used to eat even more, like butter, eggs, red meat. Gonna do some research and figure out how this is possible. Also interesting how I am leaning towards hyperthyroid, which I kinda thought for a long time now due to my high pulse and hypertension.

 

[General Orange]

I usually don't dream or at least, don't recall any dreaming when I wake up.

I already advised you to increase your GABA, and you will dream again. How is that going? What are you supplementing for GABA?
You can profit from t3 + rosemary extract, gotu kola extract with asiaticosides, and ashwagandha extract.
Thyroid hormone and gamma-aminobutyric acid (GABA) interactions in neuroendocrine systems. - PubMed - NCBI

 

[DDK]

I eat a lot of butter though, also coffee seems to give me stress reactions but I always drink it when I eat meat. Also at some point, my diet was super high in fats and I still had low cholesterol. Are there any other causes for low cholesterol?

Stop drinking coffee and milk and OJ. Try to eat more unsaturated fats instead of butter. Increase carbs substantially with starch (white wheat, white rice, potatoes) or sugar/honey/candy. Increasing carbs and lowering fats was the best way that I was able to raise my T and increase cholesterol. I'm not talking about apples and OJ, I mean dense carbs like starch/sugar/candy etc... Try eating a huge bag of skittles after dinner and see if it helps your libido? Your reaction to coffee also suggests you aren't getting enough carbs.

You didn't specifically mention what you eat at the moment but I would steer clear of "Peat" foods and eat more meat, starch, vegetables, sugar, unsaturated fats, cake, chips, candy. Stop the dairy/butter and fruits/fruit juice have pizza, candy, cake, cookies, meat, bread, etc... However, for me the sugar/candy was how I was able to raise my T to the highest levels naturally, without having to supplement or take drugs. Eating beef and fat and milk and all this "man" food will not raise your testosterone without insane amounts of carbs. Like I said above OJ doesn't really count since most of it is terrible quality/sour/acidic and doesn't contain much sugar at all.

 

[fradon]

This is an update to my old thread. For those who don't know what is going on: 19 y/o (now 20) with erectile dysfunction, can't get it up, never had morning wood in my entire life, don't have mind-penis connection, fatigue, trouble building muscle etc) Instead of waiting another month for the endo, I went to a Urologist and told him about my problems. (BTW I am 20 now).

He first checked my testicles and penis with ultrasound and said everything was fine. Then he took bloodwork and called me this week telling me he doesn't see anything abnormal in my blood levels and the cialis he prescribed me should do the work. I insisted on getting the bloodwork because I knew I couldn't trust him. I was right. Here are the blood levels. What strikes me immediately is low T, Prolactin out of range and some other levels that are clearly out of range. I can't fathom how he can tell me straight to my face that he doesn't see how my erectile dysfunction problems could correlate to these levels. I need help interpreting the rest though and a gameplan. (Apologies for any wrong translations of the levels as it is originally in German).

TSH basal (0.27 - 4.2 uU/ml) - 0.94
Free T3 (2 - 4.4 pg/ml) - 4.4
Free T4 (0.9 - 1.7 ng/dl) - 1.6
Vitamin D (31 - 100 g/ml) - 46
Gamma-Globulin (11.1-18.8 %) - 15.7

CRP quant. (<5) - <1,0 mg
LH (1.7 - 8.6 mIE/ml) - 7.7
FSH (1.5 - 12.4 mIE/ml) - 3.8
Prolactin (86 - 324 mIE/L) - 346! - clearly high Prolactin
Testosterone (2.49 - 8.36 ng/ml) - 3.93 or 393 ng/dl clearly low T

Average Blood Sugar (80 - 120 mg/dl) - 100
Cholesterol (<200 mg/dl) - 89
Triglycerides (<200 mg/dl) - 75
HDL-Cholesterin (>40 mg/dl) - 42
LDL-Cholesterol (<150) - 32

CHOL/HDL (<4.5) - 2.1
LDL/HDL (<3) - 0.8
gamma-GT (<64 U/L) - 18
GOT (10-50 U/L) - 25
GPT (10-50 U/L) - 26

Alk. Phosphatase ( 40 - 129 U/L) - 66
LDH (135 - 270 U/L) - 178
Amylase (28-100 U/L) - 62
Lipase (13 - 60 U/L) - 19
Uric Acid (<7 mg/dl) - 4.7

Creatinin (<1.2 mg/dl) - 0.9
Renal Function - 123
Potassium (3.8 - 5.3 mmol/L) - 4.6
Sodium (137 - 147 mmol/L) - 141
Calcium (2.1 - 2.6 mmol/l) - 2.4

Magnesium (0.7 - 1.05 mmol/L) - 0.98
Iron (40 - 160 ug/dl) - 169!
Acid Phosphatase (<6.6 U/L) - 5.8
Total Protein? (6.5 - 8.5 g/dl) - 7.3

Albumin (55.8-66.1%) 60.9
alpha 1 - Globulin (2.9 - 4.9 %) - 3.8
alpha 2 - Globulin (7.1 - 11.8%) - 10.8
beta 1 - Globulin (4.7 - 7.2%) - 5.4
beta 2 - globulin (3.2-6.5%) - 3.4

leukocytes (4 - 10 tsd/ul) - 10.5!
erythrocytes (4.6 - 6 Mill/ul) - 5.00
Haemoglobin (14 - 18 g/dl) - 15.1
Haematocrytes (40 - 54 Vol%) - 47
MCV (83 - 95 fl) - 94

MCH (28 -34 pg) - 30.2
MCHC (32 -36 g/dl) - 32.1
Thrombocytes (150 - 351 Tsd. cmm) -303
MTV (7.2 - 11.1) - 10.7
Neutrophile (50-70%) - 53.5

Lymphocytes (25 - 45%) - 35.3
Monocytes (2-9%) - 9.9!
Eosinophile (2-4%) - 1.0!
Basophile (0-1%) - 0.2
IG (<4) - 0.1

Microcytosis - 0.5
Macrocytosis - 4.2
EVB - (11.5 - 14.5) - 12
HBA1c (4.3 - 5.9%) - 5.1
HBA1c (23-42 /mol) - 32

What strikes me is the high prolactin, and low T. Even though I spend the last 5 years trying to optimize my male hormones, nothing worked, and I shouldn't even have to worry about it at my age. The past weeks I took B6 and tried lowering Prolactin but I am still out of range. T is incredibly low for someone my age. I will do follow up tests, check my estrogen levels and if nothing else works, I will go on TRT, I don't care anymore I just want to feel normal.

LDL seems a bit low...LDL is what body uses to make hormones (prgnenlone, dhea, testosterone, vitamin D) but the body still needs to be able to convert them and it uses VITAMIN B5

blood glucose is high for fasted glucose and iron high do you have...do you have some sort of insulin resistance. Ray peat said high iron increaeses insulin resistance...have you tried donating blood ot reduce iron over load

also if you have high iron it could be preventing copper and or zinc from being absorbed. dark chocolate is high in copper magnesiun and increases NOS and dilates the blood vessels and may increases morning wood.

but you should look into the iron over load issue and the blood sugar issue...being insulin resistance or some sort of metabolic syndrome could effect sex drive.

also cut back on the protein if you eat a lot of protein it can also lower Testosterone and raise SHBG.

 

[General Orange]

Dear, Mr Deadpool, I suspect you have high prolactin as effect of your pregnenolone being shunted into making cortisol, perhaps disorder in pituitary-adrenal function. And maybe with high cortisol causing thyroid hormone receptor insensitivity and the liver cannot make enough thyroid.

See if you can test pregnenolone, DHEA and ACTH, cortisol.

Make sure you get enough salt, half teaspoon in morning. Or make you own salt saturated water: Sole

On second thought cholesterol looks good.

 

[General Orange]

In the mean time, I would also recommend taking a not so Peaty orthomolecular approach. Consider the following:
-carb-fat-protein meals low in starch, with eggs.
-Fat intake must include: MCT / Coconut oil, and Borage / Hemp oil with meals. 2:1 SFA:PUFA,
-Pregnenolone
-DHEA
-Magnolia & Phellodendron - restore cortisol and DHEA production by supporting adrenal gland
-Phosphatidylserine high doses 10+ days - cortisol / adrenals
-Pantethine a form of B5 - liver health

 

[cardochav]

Have you considered a good LSD trip or shrooms? If you’ve lost the “brain penis connection” maybe you need neuron rewiring. Paul stamets recommends therapeutic psilocybin mushrooms and lions mane mushrooms with 200mg niacin. Might be worth looking into.

 

[vulture]

Have you considered a good LSD trip or shrooms? If you’ve lost the “brain penis connection” maybe you need neuron rewiring. Paul stamets recommends therapeutic psilocybin mushrooms and lions mane mushrooms with 200mg niacin. Might be worth looking into.

Why do you think it would be helpful?

 

[lampofred]

The way to increase cholesterol is to eat a lot of sucrose according to Peat. Your prolactin is ridiculously high. That means dopamine is low and erections/motivation/testosterone are impossible without dopamine. Does drinking a lot of coffee help your symptoms?

Also, have you gotten your liver tested? If you have high prolactin, you are not hyperthyroid, so cholesterol isn't low because it is getting converted. But the liver is responsible for making cholesterol, so if you have low cholesterol but high prolactin, that means liver production of cholesterol is low, which means it might be damaged. You said in another thread that you feel like you have PFS symptoms even though you didn't take finasteride, and Peat has said PFS is probably caused by finasteride damaging the liver and intestine. Low blood sugar and fainting is also caused by a damaged liver not able to store glycogen.

Liver disease is also associated with high prolactin.

EDIT: Bad breath and yellow skin are also signs of liver problems. I'd suggest getting a comprehensive liver test.

 

[Deadpool]

The way to increase cholesterol is to eat a lot of sucrose according to Peat. Your prolactin is ridiculously high. That means dopamine is low and erections/motivation/testosterone are impossible without dopamine. Does drinking a lot of coffee help your symptoms?

Also, have you gotten your liver tested? If you have high prolactin, you are not hyperthyroid, so cholesterol isn't low because it is getting converted. But the liver is responsible for making cholesterol, so if you have low cholesterol but high prolactin, that means liver production of cholesterol is low, which means it might be damaged. You said in another thread that you feel like you have PFS symptoms even though you didn't take finasteride, and Peat has said PFS is probably caused by finasteride damaging the liver and intestine. Low blood sugar and fainting is also caused by a damaged liver not able to store glycogen.

Liver disease is also associated with high prolactin.

EDIT: Bad breath and yellow skin are also signs of liver problems. I'd suggest getting a comprehensive liver test.

I often believe it's liver issues but I just feel like no doctor even takes anything remotely serious that I see, maybe looks at the basic blood levels at most and even if something is high like in the case with Prolactin, they just ignore it. I am gonna do research on liver health and all the other stuff you guys mentioned in this thread. Thank you all for your help! I really know that there is a light at the end of the tunnel and I just have to keep looking to find it. Thank you all for your support, seriously!

 

[vulture]

I often believe it's liver issues but I just feel like no doctor even takes anything remotely serious that I see, maybe looks at the basic blood levels at most and even if something is high like in the case with Prolactin, they just ignore it. I am gonna do research on liver health and all the other stuff you guys mentioned in this thread. Thank you all for your help! I really know that there is a light at the end of the tunnel and I just have to keep looking to find it. Thank you all for your support, seriously!

Glad to see you have hope, it's vital to keep experimenting. Try to learn, not just "fixing it". And keep us updated when you improve

 

[Ticcy-Toby]

Hey Deadpool, I am going to be extremely left field now in suggesting a technique called 'The Angion Method' that a guy called Janus Bifrons (Google the name if you want) has put forward for erectile dysfunction, I suffer with mild Peyronie's disease, guess what!, it works.
If interested just go to YouTube and look it up.

Hope it helps with the ED brother

 

[Wilfrid]

Have you try the dietary approach that @fradon and @DDK have suggested?
moderate to low protein intake, higher carbs ( white pasta, white rice ect....) and a low fat intake ( using very good EVOO as the only source of fat instead of butter; I think that you can easily find a brand like Monini and their " classico " olive oil in your supermarket, no?), if you want to give coffee another chance try the cold brew version of it....and you can also freely use cane sugar syrup as a sweetener. It makes a very pleasant and refreshing drink with any kind of salted meal.
Eat warm and very well cooked foods as much as you can ( including fruits that can even taste sweet to you ). Simple meal like cooked bamboo shoots, white rice topped with olive oil and chicken roast and cooked apples; cooked mushrooms, white pasta,olive oil and grated pecorino romano cheese, cooked peaches ect....
For your high prolactin, sometimes even 500 mcg of cypro taken before bedtime could be more than enough. As for the supplement a weekly dose of high quality vitamin E ( I think that @haidut has probably made the best vitamin E supplement so far ) and a daily dose of no more than 5-10 mg of vitamin B6 ( metabolics in the UK have a great and very pure liquid B6 HCL ) taken in the morning should help too.
Do you know your vitamin D and PTH status? A correct calcium homeostasis is required for proper insulin's function. And insulin can strongly interacts with STH (protein metabolism), testosterone, estradiol, potassium, zinc and chromium.