This is the first topical thyroid med ive tried, so my only comparison.
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This is the first topical thyroid med ive tried, so my only comparison.
I made another post not seeing this thread discussion - I'm not getting any impact from 16mcg doses and up to 80mcg a day from Tyronene, so will push it up to 25mcg doses and maybe up to 100mcg and see what happens.
Anyone else noticing less effect that with the old Grossman Cynomel tablets ?? - I never dared take half a pill (12.5mc) in one dose when I used that as would get hyper symptoms. I took 1/6th to 1/4 doses so 4-6mcg.
Do you have a thyroid Aquaman? Its possible for you that you may have a high rt3 that is competing with the t3 fir cell entry? I have no rt3 as i have no t4 in my system, but not sure of your situation.
Years ago when i changed from ndt to t3 it took 3 months on a very high t3 dosage ie about 110mcg, to feel ok while my rt3 was clearing, then all of a sudden i went hyper and had to refuce my t3 gradually down to 40 ehere i have been stable for a long time.
Do you have a thyroid Aquaman? I.
Rt3 is measured via blood like the other hormones...its usually likely though if you have a high T4 level and lowish T3. Rt3 is the bodies way of breaking down t4, prevHow do you know you had high rt3 and if one has, how does one get rid of it ? TyroMix with t3 and t4 should also be good and produce something even tho one has high rt3
Rt3 is measured via blood. Its a natural response to lower T4 levels, and in effect lower metabolism. RT3 increases in cases of illness, or fasting or from supplementing with unnecessary thyroid meds. If you have a decent level of t4 and take extra t3 it will increase rt., and if you take too much t4 it will convert to rt. to normalise levels.How do you know you had high rt3 and if one has, how does one get rid of it ? TyroMix with t3 and t4 should also be good and produce something even tho one has high rt3
Sorry, yes...i'm used to being on forums for thyroidless people lol...I meant do you have your own thyroid function? Ie, taking thyroid meds when you have a decent level will increase Rt3.You mean do I have thyroid gland? It's not been removed.
I only take a bit of T4 from the Tyromix becuase I used to mix Cynoplus and Cytomel successfully at about 1:1 ratio T3 to T4. Normally I'd take the Cynoplus later in the evening to help through the night so would still be converting some T4 to T3 as I slept. I never used to take more than 40mcg.
I only went to NDT (Tyromax) when the Mexican pharmacies stopped selling Cynoplus/Cytomel
Same, except I was away for a month in the tropics so the winter effect wasn't an issue - was taking 80mcg/day while in hot weather at a high elevation so should have been feeling it.
@haidut
A while back you posted that some rats might need higher doses of T3. After having disappointing results with thyroid in the past decided to give this advice a shot. It has been going REALLY well! Much more relaxed and no anxiety when applying 3 drops all over rat's stomach three times a day. After several days it resolved excessive sweating, that is until started slamming the coffee this week with resuming busy schedule after a long break. know Ray Peat has talked in his books about the fact that some hypothyroid people who have been relying on adrenals shouldn't use coffee while recovering so guess rat will have to go without it for the time being (super addicted tho). Although temps are actually LOWER, feel warmer in extremities and not overheated in chest and armpits etc. Heart rate is lower (high 60's to 70's) too but I feel way better than I do at 90 bpm. Also family members have commented that my hair is growing really fast, hopefully the bald patches fill in eventually :). Skin is clearer than ever also, including the back which nothing so far has helped with completely. Feels really lazy and relaxed lately but guess that is better than the extreme ups and downs going on before. Ankles are WAY less swollen, they have been really bad with swelling and varicose veins since using Mirtazapine for a couple months ( started noticing some vein issues before that too, maybe the weight gain made it worse). Noticed that using Tyromix brought the swelling back to the ankles within five minutes so it seems using T4 at this time is a bad idea. One day after using the above methods for two weeks, rat didn't use any tyronene and then randomly worked out (deadlifts etc) in the afternoon. The workout felt okay despite not lifting for a year but afterwards and the following experienced extreme hypo symptoms, dandruff got really bad for two days like it was before the tyronene improved flakes...maybe too much adrenaline and muscle breakdown blocking T3 effects? Also appetite seems different, long periods where not very hungry...
I know a lot of people have commented that Tyronene doesn't work but for my rat I've seen a lot of positives so far and hope the trajectory continues. Just to contrast with previous experiments; T3 pro - felt more like drinking two strong cups of coffee on empty stomach or zero effect...maybe the product is not very consistent in the distribution of the active hormone? Tyromax- strong adrenaline surges, just did not feel that good, heart rate extremely high- lifestyle was different in those days to though. Novitoral: felt really depressed, no libido, didn't feel good at all, very lame. Tyromix: See above.
Also I recently started using cyproheptadine (on rat) with thyroid and noticed a huge increase in testicle size and firmness. I tested with just cyproheptadine and didn't notice the same results, didn't notice much of anything really except for some hunger (haven't applied more than 6mg and usually apply on the inside of forearms, rubbing them together). The two go together really well in my experiments and right now are the only two supps rat is taking other than some vitamins. The only time hyperthyroid effects (fast heart rate, overheating, anxiety attacks) appear is when coffee is consumed. Maybe that is a sign of liver issues or just activates still oversensative adrenals. (this also gets rid of the testicle effect)
Sorry for the long winded post :)
As an update, I switched back to TyroMax yesterday and today after many months of Tyronene and Tyromix. I have 2 old bottles of Tyromax about 1/4 and 1/2 full.
The effect is noticeable. Tyronene and TyroMix really don't seem to work for me. TyroMax which I had actually thought didn't work before (I used it topically) now seems to be working orally.. Ray mentioned in a recent podcast about topical T3 not being able to effect blood concentrations enough.
I have used it in doses of 4 drops at a time orally, I had a noticeable temp, mood and pulse increase each time. Now 20 drops down through the day and feel very good. Warm, hands and feet warm and pulse over 75 resting (has been in 60s with 80mcg of Tyronene in me). Also I felt a cold coming yesterday which seems to have been knocked out by TyroMax.
HOWEVER it's clear the tyronene and TyroMix are definitely not working for me (have been regularly taking up to 80mcg T3 both orally and topically). It's not the bottle, since I have 2 separate bottles of Tyronene bought in different months and a bottle of Tyromix bought at another month.
Haidut - how confident are you in your T3 supplier? Or is there a chance the chemical is breaking down in DMSO?
The T3 supplier is top notch and their product is rock solid when used in its powder form. I have tried and tested it on many subjects. I think Ray maybe onto something with the topical T3 not raising blood levels enough. Currently waiting on analysis results from a lab to which I sent Tyronene and TyroMix samples. The lab told me that they have analyzed liquid thyroid products before and they were all fine, but I will wait for the results before I make a definitive statement.