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- Pseudomalabsorption of Levothyroxine: A Challenge for the Endocrimologist in the Treatment of Hypothyroidism
"The bioavailability of synthetic levothyroxine is approximately 80% after oral ingestion. Absorption occurs mostly in the jejunum and ileum and is enhanced by a fasting state [2,3,6,8,9,10,11]. Interference in absorption of thyroid hormones with dietary elements (soja, prunes, nuts, and herbal remedies) or medication, with the most common being cholestyramine, colestipol, aluminium hydroxide-containing antacids, propranolol, laxatives, ferrous salts, calcium carbonate, lovastatin, phenytoin, carbamazepine and rifampicin, should be excluded if euthyroidism cannot be reached using replacement therapy [1,4,5,6,8,10,12,13,14,15,16]. Other reasons for reduced absorption are high age, high fibre diets, levothyroxine intake with food and hypothyroidism [6,9,17]."
"The bioavailability of synthetic levothyroxine is approximately 80% after oral ingestion. Absorption occurs mostly in the jejunum and ileum and is enhanced by a fasting state [2,3,6,8,9,10,11]. Interference in absorption of thyroid hormones with dietary elements (soja, prunes, nuts, and herbal remedies) or medication, with the most common being cholestyramine, colestipol, aluminium hydroxide-containing antacids, propranolol, laxatives, ferrous salts, calcium carbonate, lovastatin, phenytoin, carbamazepine and rifampicin, should be excluded if euthyroidism cannot be reached using replacement therapy [1,4,5,6,8,10,12,13,14,15,16]. Other reasons for reduced absorption are high age, high fibre diets, levothyroxine intake with food and hypothyroidism [6,9,17]."
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