Type II Collagen Or Type I For Serotonin Reduction?

[Nick21]

I'm trying to discern if there is any correlation between the amount of serotonin reduction and the collagen type. A product available locally is Webber Naturals Marine Type II Collagen. It is paired with lysine, albeit in a minuscule amount (I'm currently trying Lysine at about 1-2 g per day as a trial to see if it helps with my symptoms, as I have the MAO-A defect, in concert with Famotidine). I noticed folks on this forum have championed Great Lakes collagen, which appears to be of Type I. My attempts to discern what amino acids are in Type II have not been successful, and to compare them to what is present in Type I.

 

[magnesiumania]

Well all types (including type 3 has glycin which helps balance tryptophan.

 

[bagotage]

Not sure about serotonin specifically, but type II has been studied for musculoskeletal pain, whereas type I seems to mostly be indicated for supporting skin and tissue. Making (or buying) some bone broth would probably be an even better way to get them both.

 

[Mr Joe]

Follow ! If someone could also explain the link between type II collagen and arthritis ? How safe type II collagen is compared to type I or gelatin ?

Ethyl pyruvate therapy attenuates experimental severe arthritis caused by type II collagen (CII) in the mouse (CIA) - PubMed

This study tested the hypothesis that ethyl pyruvate (EP), a simple aliphatic ester with anti-inflammatory effects, can reduce type II collagen-induced mouse arthritis (CIA). DBA/1J mice were used for the study, developing erosive hind paw arthritis when immunized with CII in an emulsion in...

pubmed.ncbi.nlm.nih.gov

Could also type II collagen influence histamine/serotonin ?

Inhibition of GSK-3β Alleviates Collagen II-Induced Rheumatoid Arthritis in Rats - PubMed

Treatment with GSK-3β inhibitor suppressed inflammatory response in RA rats. These findings suggest that the inhibition of GSK-3β can be an effective treatment for RA.

pubmed.ncbi.nlm.nih.gov

"he levels of inflammation mediators such as prostaglandin E2, 5-hydroxytryptamin, and histamine were decreased in the TDZD-8 group. "

Thank's guys !

 

[ecstatichamster]

just avoid chicken collagen.

 

[bagotage]

just avoid chicken collagen.

Really? How come? Chicken feet make the broth so good and gelatinous...

 

[bagotage]

just avoid chicken collagen.

Is this because of the way most chickens are raised today? Or something more fundamental? I have access to very clean well raised chickens

 

[ecstatichamster]

no chicken cartilage seems very toxic and causes rheumatoid arthritis. I avoid it completely. Areas where people nibble on the bones have a lot more RA.

 

[Rafael Lao Wai]

no chicken cartilage seems very toxic and causes rheumatoid arthritis. I avoid it completely. Areas where people nibble on the bones have a lot more RA.

Had never heard that before, hamster. Doesn't Ray drink chicken broth( with the fat skimmed off)?

 

[ecstatichamster]

chicken broth might be okay but cartilage is probably not good. Travis was the first to alert me to this.

[1] Kjeldsen-Kragh, Jens. "Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis." The Lancet (1991)

http://darm-gesund.de/downloads/thelancet.pdf



[2] Bagchi, D. "Effects of orally administered undenatured type II chicken collagen against arthritic inflammatory pathologies: a mechanistic exploration." International Journal of Clinical Pharmacology Research (2002)

http://mdrivesport.com/documents/collagen-research-ucii.pdf



[3] Rothbard, Sidney. "Immunologic relations among various animal collagens." Journal of Experimental Medicine (1965)

http://jem.rupress.org/content/jem/122/3/441.full.pdf



[4] Terato, Kuniaki. "Specificity of antibodies to type II collagen in rheumatoid arthritis." Arthritis & Rheumatism: Official Journal of the American College of Rheumatology (1990)

Error - Cookies Turned Off



[5] Stuart, John. "Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis." Journal of Experimental Medicine (1982)

http://jem.rupress.org/content/jem/155/1/1.full.pdf

 

[Rafael Lao Wai]

chicken broth might be okay but cartilage is probably not good. Travis was the first to alert me to this.

[1] Kjeldsen-Kragh, Jens. "Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis." The Lancet (1991)

http://darm-gesund.de/downloads/thelancet.pdf



[2] Bagchi, D. "Effects of orally administered undenatured type II chicken collagen against arthritic inflammatory pathologies: a mechanistic exploration." International Journal of Clinical Pharmacology Research (2002)

http://mdrivesport.com/documents/collagen-research-ucii.pdf



[3] Rothbard, Sidney. "Immunologic relations among various animal collagens." Journal of Experimental Medicine (1965)

http://jem.rupress.org/content/jem/122/3/441.full.pdf



[4] Terato, Kuniaki. "Specificity of antibodies to type II collagen in rheumatoid arthritis." Arthritis & Rheumatism: Official Journal of the American College of Rheumatology (1990)

Error - Cookies Turned Off



[5] Stuart, John. "Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis." Journal of Experimental Medicine (1982)

http://jem.rupress.org/content/jem/155/1/1.full.pdf

Thanks!

 

[hei]

Follow ! If someone could also explain the link between type II collagen and arthritis ? How safe type II collagen is compared to type I or gelatin ?

Ethyl pyruvate therapy attenuates experimental severe arthritis caused by type II collagen (CII) in the mouse (CIA) - PubMed

This study tested the hypothesis that ethyl pyruvate (EP), a simple aliphatic ester with anti-inflammatory effects, can reduce type II collagen-induced mouse arthritis (CIA). DBA/1J mice were used for the study, developing erosive hind paw arthritis when immunized with CII in an emulsion in...

pubmed.ncbi.nlm.nih.gov

Could also type II collagen influence histamine/serotonin ?

Inhibition of GSK-3β Alleviates Collagen II-Induced Rheumatoid Arthritis in Rats - PubMed

Treatment with GSK-3β inhibitor suppressed inflammatory response in RA rats. These findings suggest that the inhibition of GSK-3β can be an effective treatment for RA.

pubmed.ncbi.nlm.nih.gov

"he levels of inflammation mediators such as prostaglandin E2, 5-hydroxytryptamin, and histamine were decreased in the TDZD-8 group. "

Thank's guys !

It seems that they create "type-II collagen induced arthritis" by giving them an injection of collagen with an adjuvant. They call it an immunisation (against collagen). Afterwards, the mice develop antibodies against type-II collagen and start attacking their own tissues. Seems nasty. This paper describes it.

https://ard.bmj.com/content/annrheumdis/55/8/535.full.pdf

I found another paper (more of a review) claiming that oral administration of type-II collagen creates tolerance that reduces the immune response sometimes.

Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis - PubMed

Oral tolerance means a diminished immune response to previously fed antigens. Repeated oral administrations of type II collagen (CII) induce oral tolerance and inhibit the development of collagen-induced arthritis (CIA). Dendritic cells (DCs) in the gut-associated lymphoid tissue (GALT) take up...

pubmed.ncbi.nlm.nih.gov

 

[Peatness]

I'm trying to discern if there is any correlation between the amount of serotonin reduction and the collagen type. A product available locally is Webber Naturals Marine Type II Collagen. It is paired with lysine, albeit in a minuscule amount (I'm currently trying Lysine at about 1-2 g per day as a trial to see if it helps with my symptoms, as I have the MAO-A defect, in concert with Famotidine). I noticed folks on this forum have championed Great Lakes collagen, which appears to be of Type I. My attempts to discern what amino acids are in Type II have not been successful, and to compare them to what is present in Type I.

I have been looking into the different types of collagen because of this report.

https://www.ahajournals.org/doi/full/10.1161/01.cir.0000140973.60992.9a

This article gives details of the different sources of collagen

What are the 5 Types of Collagen? Their sources & if you need all 5