TSH upregulates cholesterol synthesis

Discussion in 'Scientific Studies' started by haidut, Mar 8, 2015.

  1. haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    16,614
    Gender:
    Male
    Location:
    USA / Europe
    After years (maybe decades) of denial by official medicine that thyroid status affects cholesterol levels, this study is lighting up the blogosphere. It looks like the connection between high TSH and high cholesterol is re-established and it validates some of the ideas and methods of Broda Barnes and Peat.

    http://www.ncbi.nlm.nih.gov/pubmed/25713102
    https://healthunlocked.com/thyroiduk/po ... -the-liver

    "...In Tshr-knockout mice, the ratios of liver p-HMGCR/HMGCR and p-AMPK/AMPK were increased relative to the littermate wild-type mice. Consistently, the phosphorylation of ACC, a downstream target molecular of AMPK, increased. All results suggested that TSH could regulate the phosphorylation of HMGCR via AMPK, which established a potential mechanism for hypercholesterolemia involved in a direct action of the TSH in liver."
     
Loading...