TSH is inflammatory just as Dr. Peat has always said

[ecstatichamster]

https://academic.oup.com/endo/article-abstract/162/8/bqab077/6225351

Thyroid-stimulating hormone (TSH) treatment activates inhibitor of NF-κB/nuclear factor κB (IκB/NFκB) and extracellular signal-regulated kinase (ERK)–P38 in macrophages, but how these pathways are activated, and how they contribute to the proinflammatory effect of TSH on macrophages remain unknown.

The TSH receptor (TSHR) is coupled to 4 subfamilies of G proteins (Gs, Gi/o, Gq/11, and G12/13) for its downstream signaling. This study investigated the G protein subtypes responsible for the proinflammatory effect of TSH on macrophages.

qPCR showed that Gi2, Gi3, Gas, Gq, G11, G12, G13, and G15 are abundantly expressed by macrophages. The contribution of different G protein pathways to the proinflammatory effect was studied by the corresponding inhibitors or siRNA interference.

While TSH-induced IκB phosphorylation was not inhibited by Gs inhibitor NF449, Gi inhibitor pertussis toxin, or Gq or G11 siRNA, it was blocked by phospholipase C inhibitor U73122 or G15 siRNA interference.

TSH-induced ERK and P38 phosphorylation was blocked by G13 but not G12 siRNA interference.

Interference of either G13 or G15 could block the proinflammatory effect of TSH on macrophages. The present study demonstrate that TSH activates macrophage inflammation by the G13/ERK–P38/Rho GTPase and G15/phospholipase C (PLC)/protein kinases C (PKCs)/IκB pathways.

 

[xeliex]

Good stuff! Thank you.

 

[Yann]

Thanks!

 

[Grapelander]

PKC

Verbascoside is a PKC inhibitor. It is related to hydroxytyrosol and caffeic acids.

Wikipedia:
In the family Lamiaceae, it can be found in the medicinal plants in the genus Phlomis, in the Scrophulariaceae, in Verbascum phlomoides, Verbascum mallophorum, or, in the family Buddlejaceae, in Buddleja globosa or Buddleja cordata, in the family Bignoniaceae, in Pithecoctenium sp and Tynanthus panurensis, in the family Orobanchaceae, in Cistanche sp and Orobanche rapum-genistae, in the Plantaginaceae, in Plantago lanceolata, in Verbenaceae, in Verbena officinalis (common vervain),[11] Aloysia citrodora (lemon verbena) and Lantana camara, in the Oleaceae, in Olea europaea (olive), in the Lentibulariaceae, in the carnivorous plant Pinguicula lusitanica, and, in the Byblidaceae, in Byblis liniflora.