True Or False? Pregnenolone Does Not Decrease With Age

[Captain_Coconut]

This study I have seen referenced a few places that claim pregnenolone does not decline significantly with age.

Changes in circulating steroids with aging in postmenopausal women. - PubMed - NCBI

What are your thoughts, oh wise RP Forum members?

This study on men also claims the changes are small.... Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men. - PubMed - NCBI

 

[Captain_Coconut]

Another one:

Menopause related changes of adrenocortical steroid production. - PubMed - NCBI

 

[Captain_Coconut]

Bump

 

[haidut]

Here is at least one study that says otherwise.
Pregnenolone, Progesterone And DHEA Drop, Cortisol Rises In Aging

 

[invictus]

Clin Chem Lab Med
. 1999 Apr;37(4):439-47.
doi: 10.1515/CCLM.1999.072.

Age relationships and sex differences in serum levels of pregnenolone and 17-hydroxypregnenolone in healthy subjects​

M Hill 1, D Lukác, O Lapcík, J Sulcová, R Hampl, V Pouzar, L Stárka
Affiliations expand

• PMID: 10369116
• DOI: 10.1515/CCLM.1999.072