Good post! Completely agree with oils being great backup. Remembering to reapply as the esters evaporate so quickly is all I would add.For the thymoquinone, I would buy cold-pressed oil instead of the CO2 extract, because the cold-pressed oil will probably still have about 2-4% thymoquinone and several brands sell it for about $25 for 8 oz compared to $61 for 8 oz of the CO2 extract.
Maybe there is something in the CO2 extract that's not in the cold-pressed oil that'd make it worth the money. This study (from post #387 on page 20 of this thread) said:
Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide by Venkatachallam et al., 2010
Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide
Chemical composition of black cumin (Nigella sativa L.) seed extracts obtained by supercritical carbon dioxide at two different conditions that result in total extract (28 MPa/50°C, SFE 1) and major volatile part (12 MPa/40°C, ...www.ncbi.nlm.nih.gov
"Chemical composition of black cumin (Nigella sativa L.) seed extracts obtained by supercritical carbon dioxide... Forty-seven volatile compounds were detected where sixteen compounds were reported for the first time in the oil of this seed."
So I don't know what those sixteen would do, but if you can afford much of the CO2 extract, at least one of those 16 probably does something to complement prion-preventing effects of what's in the cold-pressed oil.
The study in my post #400, about blood brain barrier-healing by interacting with brain proteins, was about thymohydroquinone. Thymohydroquinone is 0.06% of the volatile components of the CO2 extract, compared to thymoquinone being 43% of the volatile components. The amount of thymohydroquinone in the CO2 extract is about 0.14% of the amount of thymoquinone. Thymoquinone is 3.1% of the total components, so thymohydroquinone is about 0.00423% of the CO2 extract total components.
I don't know what minimum dose of thymohydroquinone would be useful for effects like in the study in post #400, but I'm guessing it'd get expensive to dose thymohydroquinone using the CO2 extract. But if thymoquinone also does what thymohydroquinone did in that study, there's (I'm guessing) useful-for-prion-prevention somewhat-BBB-healing amounts of thymoquinone in the cold-pressed oil too.
I wouldn't feel like I'm missing out with the cold-pressed oil because the plant's gotten its reputation for centuries from just the seeds and cold-pressed oil; CO2 extract was invented recently. Although so was the modified spike protein. Yeah but by that logic that a recently invented processing and/or delivery method is needed to be strong enough against the modified spike protein's effects, why the CO2 extract of black cumin seed, why not a nano-carrier formulation of a CO2 extract of some other herb, for example? I don't have the money to assume which not-much-studied recently invented processing or delivery methods are worth trying (unless I'm assuming none of them) instead of the traditional processing and delivery methods that there's more probably-applicable (in context of the modified spike proteins) evidence about.
This study is a good review of the cold-pressed oil composition:
A Comprehensive Review of the Physicochemical, Quality and Nutritional Properties of Nigella Sativa Oil
by Mazaheri et al., 2019
And back to how to dose the thymoquinone by milligrams -- if the percent thymoquinone is 3%, we can calculate by weight percentage how many milligrams of thymoquinone in how many grams of oil. But the oil is poured in fluid ounces, so it'd be convenient for one of us to measure how many grams one ounce of the oil weighs. I don't have a bottle of the oil or a scale right now. (I'm making tea with the ground black cumin seeds, milk thistle seeds, licorice, curry spice blend, pau d'arco, green tea, and propolis vodka, for the overlapping supporting and complementary chemicals strategy; and less often, more careful dosages, cinchona bark tea. I'm getting Ivermectin soon too.)
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More about essential oils... I haven't found specific studies with details proving this yet, but I expect essential oils to be useful to prevent spike proteins that are inhaled from getting onto cells, if the oils are on the membranes in the nose and being inhaled to the olfactory bulb (or some other thing at the top of the nose I don't know of that would absorb the chemicals instead of the olfactory bulb). In Ayurveda there's a technique called nasya of using a dropper to put infused carrier oils or essential oils diluted with carrier oils into the nose and then you snort it up into the top of the nose where it affects the brain more (I don't know how anatomically). Don't do it with non-diluted essential oils; some can cause long-term damage. This is a good book about Ayurveda's panchkarma methods, which includes nasya:
Ayurveda and Panchakarma by Sunil Joshi
Library Genesis: Sunil V. Joshi. - Ayurveda and Panchakarma : the science of healing and rejuvenation
Library Genesis is a scientific community targeting collection of books on natural science disciplines and engineering.libgen.is
I had about 3/4 of an ounce of black cumin seed oil sitting around, and put a few drops each of frankincense, myrrh, rose otto, and spruce needle essential oils into that, and I've been putting that in my nose when I'm in public where I expect to inhale some spike proteins.
Some essential oils are useful internally, orally, digested, but you gotta be careful about how to dilute them in a carrier oil depending which essential oil it is, and some aren't safe to ingest any of. Frankincense and myrrh you can add two or three drops per ounce of carrier oil (like black cumin seed) and it's safe to ingest those. Those are two that are generally good for immune system and brain health, and so, without specific studies to suggest which other oils might be better, they're a good bet to be a good value against the spike proteins.