seano
Member
Let's use this thread to document the best practices for transdermal/topical delivery.
A few things that come to mind:
a) Ideal location(s) on body & timing for applying transdermal supplements?
b) Ingredients/formulation to maximize absorption (e.g. oils, msm, dmso, ...)?
c) Supplements which are most viable for transdermal delivery. Those that are not.
d) ...
Any topical or related topic is welcome: fat-soluble vitamins (A,D,K2,...), minerals (magnesium), hormones (progesterone), ...
I'll update this 1st post with collected agreement/answers
References:
- Journal: Regional Variation in Percutaneous Penetration in Man -- Howard I. Maibach MD , Robert J. Feldmann MD , Thomas H. Milby MD & William F. Serat PhD (1971) (thanks @Wilfrid)
- Slides: Slideshare: Penetration enhancers Used in transdermal drug delivery: Technical presentation. See last slide for many other references.
- Book: Topical Absorption of Dermatological Products by Robert L. Bronaugh and Howard I. Maibach (thanks @Wilfrid)
- Authors: Howard I. Maibach (pioneer in this area) (thanks @Wilfrid)
- Authors: Pr.Adrian Williams (thanks @Wilfrid)
RP & Community Quotes:
A few things that come to mind:
a) Ideal location(s) on body & timing for applying transdermal supplements?
b) Ingredients/formulation to maximize absorption (e.g. oils, msm, dmso, ...)?
c) Supplements which are most viable for transdermal delivery. Those that are not.
d) ...
Any topical or related topic is welcome: fat-soluble vitamins (A,D,K2,...), minerals (magnesium), hormones (progesterone), ...
I'll update this 1st post with collected agreement/answers
References:
- Journal: Regional Variation in Percutaneous Penetration in Man -- Howard I. Maibach MD , Robert J. Feldmann MD , Thomas H. Milby MD & William F. Serat PhD (1971) (thanks @Wilfrid)
- Slides: Slideshare: Penetration enhancers Used in transdermal drug delivery: Technical presentation. See last slide for many other references.
- Book: Topical Absorption of Dermatological Products by Robert L. Bronaugh and Howard I. Maibach (thanks @Wilfrid)
- Authors: Howard I. Maibach (pioneer in this area) (thanks @Wilfrid)
- Authors: Pr.Adrian Williams (thanks @Wilfrid)
RP & Community Quotes:
RP said:post 113851
- The oily vitamins are well absorbed, but it depends on the skin, and how often the person washes. 5% is probably a typical absorption.
- Water soluble vitamins are poorly absorbed, but covering a large area a significant amount is absorbed.
- The legs, inner arms, tops of feet, and throat are good places for transdermal absorption."
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