Topical T3 Dramatically Stimulates Hair Growth

haidut

Member
Joined
Mar 18, 2013
Messages
17,433
Location
USA / Europe
I am posting this just a quick follow up and possible enhancement over the approach discussed in my previous post on estrogen causing hair loss. The study below demonstrated that applying daily the HED of a few mcg of T3 per square inch of skin increased hair length by several thousand percent. As such, a combination of an anti-estrogen discussed in the post above and a T3 solution (in ethanol, acetone, etc) may very well be synergistic for hair growth.

Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats - PubMed
"...The skin is a classic target tissue for thyroid hormone action. Although the histology of skin in hypothyroid states is well documented, the literature contains little assessment of skin in thyrotoxic states. In light of the paucity of information on skin under the influence of excess thyroid hormone, we investigated the direct effect of thyroid hormone on skin. Triiodothyronine (T3) was applied topically daily in liposomes to SKH-1 hairless mice for 7 days and to CD rats for 2 weeks. There was a dose-dependent increase in epidermal proliferation, dermal thickening, and hair growth in T3-treated animals. Mice that received 3.8 microg of T3 had 42% more hairs per millimeter than controls (p < 0.01), hair length that was 1,180% longer (p < 0.001), 49% greater epidermal 3H-thymidine incorporation (p < 0.01), and 80% more 5-bromo-2'-deoxyuridine (BrdU) stained cells (p < 0.05). Rats receiving 12.8 microg T3 had 48% greater dermal thickness than controls (p < 0.001), 26% greater epidermal thickness (p < 0.001), 85% more hairs per millimeter (p < 0.005), and 130% greater 3H-thymidine incorporation into the epidermis (p < 0.01). Thus, topically applied thyroid hormone has dramatic effects on both skin and hair growth. These observations offer a new strategy for developing thyroid hormone and its analogues for treating disorders of skin and hair growth."
 

Broken man

Member
Joined
Sep 11, 2016
Messages
1,426
Ye, I tried it but only for few days because I have the eugenol version and its irritating my skin.
 

Risingfire

Member
Joined
May 10, 2016
Messages
451
I tried it but vodka makes my scalp dry...
I've tried tyronene for a few days but never gave it a chance. Seemed to be fine on my scalp. I wonder if you use progesterone in conjunction right after will hydrate your skin and amplify the effect
 

Broken man

Member
Joined
Sep 11, 2016
Messages
1,426
I've tried tyronene for a few days but never gave it a chance. Seemed to be fine on my scalp. I wonder if you use progesterone in conjunction right after will hydrate your skin and amplify the effect
I am using tyromax and for like 2 weeks, for now, only thing thing that changed about my hair is that its not curly like it was before and Its calming effect on my head.
 

Traveler186

New Member
Joined
Jun 4, 2020
Messages
4
I am posting this just a quick follow up and possible enhancement over the approach discussed in my previous post on estrogen causing hair loss. The study below demonstrated that applying daily the HED of a few mcg of T3 per square inch of skin increased hair length by several thousand percent. As such, a combination of an anti-estrogen discussed in the post above and a T3 solution (in ethanol, acetone, etc) may very well be synergistic for hair growth.

Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats - PubMed
"...The skin is a classic target tissue for thyroid hormone action. Although the histology of skin in hypothyroid states is well documented, the literature contains little assessment of skin in thyrotoxic states. In light of the paucity of information on skin under the influence of excess thyroid hormone, we investigated the direct effect of thyroid hormone on skin. Triiodothyronine (T3) was applied topically daily in liposomes to SKH-1 hairless mice for 7 days and to CD rats for 2 weeks. There was a dose-dependent increase in epidermal proliferation, dermal thickening, and hair growth in T3-treated animals. Mice that received 3.8 microg of T3 had 42% more hairs per millimeter than controls (p < 0.01), hair length that was 1,180% longer (p < 0.001), 49% greater epidermal 3H-thymidine incorporation (p < 0.01), and 80% more 5-bromo-2'-deoxyuridine (BrdU) stained cells (p < 0.05). Rats receiving 12.8 microg T3 had 48% greater dermal thickness than controls (p < 0.001), 26% greater epidermal thickness (p < 0.001), 85% more hairs per millimeter (p < 0.005), and 130% greater 3H-thymidine incorporation into the epidermis (p < 0.01). Thus, topically applied thyroid hormone has dramatic effects on both skin and hair growth. These observations offer a new strategy for developing thyroid hormone and its analogues for treating disorders of skin and hair growth."

Haidut. Can you tell us the correct dosing for a rat of say 100kg? Similar to the topical Progesterone in the Estrogen not Androgens article?
 
Similar threads
Thread starter Title Forum Replies Date
MyUsernameHere Topical taurine, anyone tried? Hair & Nails 3
Inaut Topical Agmatine For Hair Loss Hair & Nails 0
R DMSO vs ethanol for maximum topical absorption? Ask For Help or Advice 0
G Topical DHEA for hair loss?!? Hair & Nails 42
B DHEA Solution for topical application, how to make it? Skin 5
R Topical magnesium citrate? Hair & Nails 2
A Help Stretch Marks/slight Loose Skin (oral/topical Skin 5
J Progest E Topical Ask For Help or Advice 0
GuiCHE DIY Topical Progesterone? Supplements, Pharmaceutical Drugs 2
johnwester130 Best Topical Antifungal? Hair & Nails 54
AnaU Topical Vitamin E -> Rash? Supplements, Pharmaceutical Drugs 2
E How Bad Is Topical Ciprofloxacin (Ear Drops)? Ask For Help or Advice 14
Gohan Topical Steroids Ask For Help or Advice 13
L New Topical Finasteride Hair & Nails 6
vulture Best Solvent For Topical DHEA In Genitals Thyroid and Hormones 13
L Help With Topical T3 Daily Dosage Metabolism 3
Highserotonin90 Topical Vitamins Application Experiments 0
haidut Topical DHEA Has Potent Anti-aging Effects On Human Skin Scientific Studies 8
L Topical T3 For Hair Growth Hair & Nails 47
ecstatichamster Apply Topical Supplements To Your Belly Button Supplements 29
C Questions On DIY Topical B Vitamins Supplements, Pharmaceutical Drugs 49
ecstatichamster Topical Agmatine Aqueous Lowering Intraocular Pressure Eyes, Ears, Nose and Headaches/Migraines 5
wealthofwisdom Is Now Topical Progesterone Good? Ask For Help or Advice 31
L Please Help, Homemade Topical Hair Cream Hair & Nails 14
K Are You Aware Peat Does Not Believe Topical Thyroid Hormones To Be Helpful? Email Advice 21
I Topical Retinoids - Do They Really Increase Collagen Production? Skin 7
Peatogenic Topical Antifungal Options (D3 As Anti Staph?) Skin 31
Peatogenic Does Location And Variety Of Topical Application Points Affect Absorption? Supplements, Pharmaceutical Drugs 3
Ficini Niacinamide Topical Vs Oral Clarification B3/Niacinamide 2
J Topical Propecia/Finasteride For Hair Loss Hair & Nails 31
opethfeldt Progesterone Oral Vs Topical Progesterone 26
R Topical Retinoids, Good For Anything ? Supplements, Pharmaceutical Drugs 5
R Need An Opinion Regards Vitamin A Topical / Oral Supplements, Pharmaceutical Drugs 10
methylenewhite Topical Serotonin Antagonist Ketanserin Improves Wound Healing Up To 150% Scientific Studies 0
Evgenij Topical Administration Of Benfotiamine B1 2
ScurveDream How To Gauge The Effectiveness Of Topical Vitamin Administration/etc. Ask For Help or Advice 0
Herbie Topical Application Of Dihydrotestosterone And Testosterone Fixed Combination Formulation For Promot Scientific Studies 0
L Theophylline Topical Has Interesting Properties Articles & Scientific Studies 1
bornamachine Topical Vitamin E Instant Effects E 21
N Topical Estrogen On Scalp For Hair Hair & Nails 62
H Ingested Topical Cyproheptadine. Should I Be Worried? Supplements, Pharmaceutical Drugs 1
GorillaHead Creating A Topical Forskolin From Extract Supplements, Pharmaceutical Drugs 0
ScurveDream Long-term Hydrocortisone Topical Application -- Bad? Ask For Help or Advice 11
Lorof Topical Arginine Ask For Help or Advice 1
GorillaHead Any Topical Estrogen Blockers Anyone Is Aware Of? Supplements, Pharmaceutical Drugs 1
O Topical Minoxidil Analog Male Issues 18
Void Interested In ISRIB But Was Wondering If/how I Can Make It Suitable For Topical Administration Ask For Help or Advice 3
M Vit D, K2, DHEA/PREG (topical? Just Ethanol) Vitamins 7
Repas du soir Topical Vitamin D3 From Cod Liver, Lanolin, Or Lichen. Which Is Best? Supplements, Pharmaceutical Drugs 3
I Hair Repigmentation With Topical T3 Hair & Nails 9

Similar threads

Top