Topical T3 Dramatically Stimulates Hair Growth

haidut

Member
Joined
Mar 18, 2013
Messages
18,026
Location
USA / Europe
I am posting this just a quick follow up and possible enhancement over the approach discussed in my previous post on estrogen causing hair loss. The study below demonstrated that applying daily the HED of a few mcg of T3 per square inch of skin increased hair length by several thousand percent. As such, a combination of an anti-estrogen discussed in the post above and a T3 solution (in ethanol, acetone, etc) may very well be synergistic for hair growth.

Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats - PubMed
"...The skin is a classic target tissue for thyroid hormone action. Although the histology of skin in hypothyroid states is well documented, the literature contains little assessment of skin in thyrotoxic states. In light of the paucity of information on skin under the influence of excess thyroid hormone, we investigated the direct effect of thyroid hormone on skin. Triiodothyronine (T3) was applied topically daily in liposomes to SKH-1 hairless mice for 7 days and to CD rats for 2 weeks. There was a dose-dependent increase in epidermal proliferation, dermal thickening, and hair growth in T3-treated animals. Mice that received 3.8 microg of T3 had 42% more hairs per millimeter than controls (p < 0.01), hair length that was 1,180% longer (p < 0.001), 49% greater epidermal 3H-thymidine incorporation (p < 0.01), and 80% more 5-bromo-2'-deoxyuridine (BrdU) stained cells (p < 0.05). Rats receiving 12.8 microg T3 had 48% greater dermal thickness than controls (p < 0.001), 26% greater epidermal thickness (p < 0.001), 85% more hairs per millimeter (p < 0.005), and 130% greater 3H-thymidine incorporation into the epidermis (p < 0.01). Thus, topically applied thyroid hormone has dramatic effects on both skin and hair growth. These observations offer a new strategy for developing thyroid hormone and its analogues for treating disorders of skin and hair growth."
 

Broken man

Member
Joined
Sep 11, 2016
Messages
1,595
Ye, I tried it but only for few days because I have the eugenol version and its irritating my skin.
 

Risingfire

Member
Joined
May 10, 2016
Messages
570
I tried it but vodka makes my scalp dry...
I've tried tyronene for a few days but never gave it a chance. Seemed to be fine on my scalp. I wonder if you use progesterone in conjunction right after will hydrate your skin and amplify the effect
 

Broken man

Member
Joined
Sep 11, 2016
Messages
1,595
I've tried tyronene for a few days but never gave it a chance. Seemed to be fine on my scalp. I wonder if you use progesterone in conjunction right after will hydrate your skin and amplify the effect
I am using tyromax and for like 2 weeks, for now, only thing thing that changed about my hair is that its not curly like it was before and Its calming effect on my head.
 

Traveler186

New Member
Joined
Jun 4, 2020
Messages
4
I am posting this just a quick follow up and possible enhancement over the approach discussed in my previous post on estrogen causing hair loss. The study below demonstrated that applying daily the HED of a few mcg of T3 per square inch of skin increased hair length by several thousand percent. As such, a combination of an anti-estrogen discussed in the post above and a T3 solution (in ethanol, acetone, etc) may very well be synergistic for hair growth.

Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats - PubMed
"...The skin is a classic target tissue for thyroid hormone action. Although the histology of skin in hypothyroid states is well documented, the literature contains little assessment of skin in thyrotoxic states. In light of the paucity of information on skin under the influence of excess thyroid hormone, we investigated the direct effect of thyroid hormone on skin. Triiodothyronine (T3) was applied topically daily in liposomes to SKH-1 hairless mice for 7 days and to CD rats for 2 weeks. There was a dose-dependent increase in epidermal proliferation, dermal thickening, and hair growth in T3-treated animals. Mice that received 3.8 microg of T3 had 42% more hairs per millimeter than controls (p < 0.01), hair length that was 1,180% longer (p < 0.001), 49% greater epidermal 3H-thymidine incorporation (p < 0.01), and 80% more 5-bromo-2'-deoxyuridine (BrdU) stained cells (p < 0.05). Rats receiving 12.8 microg T3 had 48% greater dermal thickness than controls (p < 0.001), 26% greater epidermal thickness (p < 0.001), 85% more hairs per millimeter (p < 0.005), and 130% greater 3H-thymidine incorporation into the epidermis (p < 0.01). Thus, topically applied thyroid hormone has dramatic effects on both skin and hair growth. These observations offer a new strategy for developing thyroid hormone and its analogues for treating disorders of skin and hair growth."

Haidut. Can you tell us the correct dosing for a rat of say 100kg? Similar to the topical Progesterone in the Estrogen not Androgens article?
 
Similar threads
Thread starter Title Forum Replies Date
shine Topical testosterone on neck/throat for deeper voice? Hormones 2
johnwester130 Topical Pirfenidone - The real answer to inflammation and fibrosis. Not taurine, MSM, serrapeptase etc Hair & Nails 12
M Does topical zinc get absorbed? Ask For Help or Advice 11
miquelangeles GABA, PharmaGABA, topical GABA, liposomal GABA Supplements, Pharmaceutical Drugs 0
jpgio How much topical progesterone (progest-e) to start with for a man? Progesterone 14
G Is topical minoxidil harmful? Ask For Help or Advice 2
johnwester130 These people once tried a topical aromatase inhibitor for baldness Hair & Nails 1
J Safe topical treatment to use on cuts to avoid infection Skin 39
haidut Vitamin D (topical) safe and effective for removing scars Scientific Studies 2
P Topical Progesterone to heal scar tissue? Progesterone 22
johnwester130 Topical bromelain for fibrosis and excess hardened collagen/fibrin Hair & Nails 11
S Anyone got a trusted topical progesterone cream they use?? Progesterone 7
E Can I use oral Ginko biloba and topical minoxidil? Ask For Help or Advice 4
GorillaHead Can Skin PUFA be displaced with topical saturated application? Skin 6
J Topical asprin vs salicylic acid Hair & Nails 6
M Will topical zinc cause grey hair ? Hair & Nails 3
A Topical Gonadin/ Kuinone Diet 6
F Did anyone reversed grey hairs with topical copper? Hair & Nails 116
F Topical Tocovit Danny Roddy 9
ImprovingDaily Anyone know how to make topical Cascara Sagrada? Skin 15
M ADEK - Why are people taking it topical? Diet 3
U How much DMSO for topical solution? Supplements, Pharmaceutical Drugs 4
Pina Topical Lung T3 Treatment COVID-19 Acute Respiratory Distress Syndrome Thyroid and Hormones 0
R Safety of topical antibiotic clindamycin 1% with benzoyl peroxide 2.5% for acne? Ask For Help or Advice 0
youngsinatra Post Your Experience With Topical Vitamin A Here Metabolism 31
haidut Topical DHT therapy promotes hair growth Scientific Studies 22
M How much of topical zinc (scalp) will go systemically? Ask For Help or Advice 7
M Topical Dutasteride = no systemic absorbtion?? Hair & Nails 67
S Question about topical delivery mechanisms for scalp Hair & Nails 0
MyUsernameHere Topical taurine, anyone tried? Hair & Nails 4
Inaut Topical Agmatine For Hair Loss Hair & Nails 3
R DMSO vs ethanol for maximum topical absorption? Ask For Help or Advice 1
G Topical DHEA for hair loss?!? Hair & Nails 134
B DHEA Solution for topical application, how to make it? Skin 11
R Topical magnesium citrate? Hair & Nails 2
A Help Stretch Marks/slight Loose Skin (oral/topical Skin 20
J Progest E Topical Ask For Help or Advice 1
GuiCHE DIY Topical Progesterone? Supplements, Pharmaceutical Drugs 6
johnwester130 Best Topical Antifungal? Hair & Nails 61
AnaU Topical Vitamin E -> Rash? Supplements, Pharmaceutical Drugs 2
E How Bad Is Topical Ciprofloxacin (Ear Drops)? Ask For Help or Advice 14
Gohan Topical Steroids Ask For Help or Advice 13
L New Topical Finasteride Hair & Nails 6
vulture Best Solvent For Topical DHEA In Genitals Thyroid and Hormones 13
L Help With Topical T3 Daily Dosage Metabolism 3
Highserotonin90 Topical Vitamins Application Experiments 0
haidut Topical DHEA Has Potent Anti-aging Effects On Human Skin Scientific Studies 8
L Topical T3 For Hair Growth Hair & Nails 50
ecstatichamster Apply Topical Supplements To Your Belly Button Supplements 29
C Questions On DIY Topical B Vitamins Supplements, Pharmaceutical Drugs 51

Similar threads

Top