Topical DIM to accelerate wound healing

David PS

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Topical DIM has synergy with tobramycin (the antibiotic used in the study).
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Anti-Virulence Activity of 3,3′-Diindolylmethane (DIM): A Bioactive Cruciferous Phytochemical with Accelerated Wound Healing Benefits

Abstract

Antimicrobial resistance is among the top global health problems with antibacterial resistance currently representing the major threat both in terms of occurrence and complexity.

One reason current treatments of bacterial diseases are ineffective is the occurrence of protective and resistant biofilm structures.

Phytochemicals are currently being reviewed for newer anti-virulence agents.

In the present study, we aimed to investigate the anti-virulence activity of 3,3′-diindolylmethane (DIM), a bioactive cruciferous phytochemical.

Using a series of in vitro assays on major Gram-negative pathogens, including transcriptomic analysis, and in vivo porcine wound studies as well as in silico experiments, we show that DIM has anti-biofilm activity. Following DIM treatment, our findings show that biofilm formation of two of the most prioritized bacterial pathogens Acinetobacter baumannii and Pseudomonas aeruginosa was inhibited respectively by 65% and 70%.

Combining the antibiotic tobramycin with DIM enabled a high inhibition (94%) of P. aeruginosa biofilm.

I am wondering if topical DIM, which is available over-the-counter, would be helpful to have for the upcoming zombie apocalypse. :clown:
See also:
Could a phytochemical derived from vegetables like broccoli be the answer to antibiotic resistant pathogens?
 

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