BigYellowLemon
Member
- Joined
- Jul 6, 2016
- Messages
- 550
Cigarette smoke negatively and dose-dependently affects the biosynthetic pathway of the n-3 polyunsaturated fatty acid series in human mammary epit... - PubMed - NCBI
"The data indicate that exposure to cigarette smoke negatively affects the synthesis of n-3 LC-PUFA from the precursor in mammary gland cells."
The in vitro effects of cigarette smoke on fatty acid metabolism are partially counteracted by simvastatin. - PubMed - NCBI
"CS decreases PUFA conversion and its effects are modulated by the opposite effect of statins. It can be speculated that statin treatments in smoking patients may provide some beneficial effects on PUFA metabolism in addition to lowering cholesterol levels." hahahah nooooo are you kidding me they ****** recommend givings smokers statins, my god.
Effects of cigarette smoke on cell viability, linoleic acid metabolism and cholesterol synthesis, in THP-1 cells. - PubMed - NCBI
"In conclusion, CS affects lipid metabolism, inhibiting LA conversion and desaturase activities. CS also shifts the "de novo" lipid synthesis from free cholesterol to TG and CE, where LA is preferentially esterified."
Basically cigarette smoke effects the conversion of shorter PUFA's to longer PUFA's. I really have no idea what this would mean in the live organism. The ROS from the cigarette smoke might balance out or it might not with the effects it has on PUFA, probably not imo. I would recommend not smoking, I smoked for over a year, it was meh.
"The data indicate that exposure to cigarette smoke negatively affects the synthesis of n-3 LC-PUFA from the precursor in mammary gland cells."
The in vitro effects of cigarette smoke on fatty acid metabolism are partially counteracted by simvastatin. - PubMed - NCBI
"CS decreases PUFA conversion and its effects are modulated by the opposite effect of statins. It can be speculated that statin treatments in smoking patients may provide some beneficial effects on PUFA metabolism in addition to lowering cholesterol levels." hahahah nooooo are you kidding me they ****** recommend givings smokers statins, my god.
Effects of cigarette smoke on cell viability, linoleic acid metabolism and cholesterol synthesis, in THP-1 cells. - PubMed - NCBI
"In conclusion, CS affects lipid metabolism, inhibiting LA conversion and desaturase activities. CS also shifts the "de novo" lipid synthesis from free cholesterol to TG and CE, where LA is preferentially esterified."
Basically cigarette smoke effects the conversion of shorter PUFA's to longer PUFA's. I really have no idea what this would mean in the live organism. The ROS from the cigarette smoke might balance out or it might not with the effects it has on PUFA, probably not imo. I would recommend not smoking, I smoked for over a year, it was meh.