Tideglusib - Alzheimer drug can regrow enamel

[johnwester130]

Researchers Develop Novel Method to Repair Teeth using Alzheimer’s Drug Tideglusib | Sci.News

A novel method of stimulating the renewal of living stem cells in tooth pulp using an Alzheimer’s drug called Tideglusib has been discovered by scientists at King’s College London, UK.

www.sci-news.com

 

[aliml]

Tideglusib is a Glycogen synthase kinase 3 beta (GSK3B).

GSK3B is an enzyme associated with energy metabolism, neuronal cell development, and body pattern formation.

GSK3 has been implicated in various diseases such as diabetes, inflammation, cancer, Alzheimer's and bipolar disorder.

Inhibitors of GSK3B activity could be useful in prostate, Glioblastoma, neuroblastoma, pancreatic and colorectal cancer therapy, improve insulin response and maintain proper glucose levels.

Inhibitors of GSK3B (in forebrain) are important for reducing anxiety and depression by way of serotonin pathway effects.

Suppression of GSK3B in the brain (forebrain) increases sociability, which would mean that it can be useful for autism.

GSK3B inhibition (hippocampus and striatum) increases resilience to defeat and decreases responsiveness to psychostimulants.

GSK3B inhibition stimulates the regeneration of myelin forming cells and remyelination following chemically induced demyelination.

GSK3B inhibition stimulates axon regeneration in injured cortical connections.

Damaged axons in the adult central nervous system normally do not regenerate after lesion, largely because of the presence of growth inhibitory molecules at the scar.

Substances That Decrease GSK3B:

-- Resveratrol
-- Progesterone
-- Zinc
-- NAC
-- Berberine
-- Melatonin
-- Palm Oil
-- Coenzyme Q10
-- Aspirin
-- Copper
-- Vitamin C
-- Curcumin
-- Garlic Extract
-- Apple polyphenol extract
-- Pregnanolone
-- Propranolol
-- Niclosamide
-- Methionine
-- Sodium Selenite
-- Naloxone
-- Losartan
-- Colchicine

Selfdecode

Use SelfDecode to get personalized health recommendations based on your genes. Get started today with an existing DNA file or order a SelfDecode DNA kit!

selfdecode.com

 

[Kray]

Tideglusib is a Glycogen synthase kinase 3 beta (GSK3B).

GSK3B is an enzyme associated with energy metabolism, neuronal cell development, and body pattern formation.

GSK3 has been implicated in various diseases such as diabetes, inflammation, cancer, Alzheimer's and bipolar disorder.

Inhibitors of GSK3B activity could be useful in prostate, Glioblastoma, neuroblastoma, pancreatic and colorectal cancer therapy, improve insulin response and maintain proper glucose levels.

Inhibitors of GSK3B (in forebrain) are important for reducing anxiety and depression by way of serotonin pathway effects.

Suppression of GSK3B in the brain (forebrain) increases sociability, which would mean that it can be useful for autism.

GSK3B inhibition (hippocampus and striatum) increases resilience to defeat and decreases responsiveness to psychostimulants.

GSK3B inhibition stimulates the regeneration of myelin forming cells and remyelination following chemically induced demyelination.

GSK3B inhibition stimulates axon regeneration in injured cortical connections.

Damaged axons in the adult central nervous system normally do not regenerate after lesion, largely because of the presence of growth inhibitory molecules at the scar.

Substances That Decrease GSK3B:

-- Resveratrol
-- Progesterone
-- Zinc
-- NAC
-- Berberine
-- Melatonin
-- Palm Oil
-- Coenzyme Q10
-- Aspirin
-- Copper
-- Vitamin C
-- Curcumin
-- Garlic Extract
-- Apple polyphenol extract
-- Pregnanolone
-- Propranolol
-- Niclosamide
-- Methionine
-- Sodium Selenite
-- Naloxone
-- Losartan
-- Colchicine

Selfdecode

Use SelfDecode to get personalized health recommendations based on your genes. Get started today with an existing DNA file or order a SelfDecode DNA kit!

selfdecode.com

View attachment 28515

Researchers Develop Novel Method to Repair Teeth using Alzheimer’s Drug Tideglusib | Sci.News

A novel method of stimulating the renewal of living stem cells in tooth pulp using an Alzheimer’s drug called Tideglusib has been discovered by scientists at King’s College London, UK.

www.sci-news.com

@aliml
Just saw this thread today- since you posted have you found further information on this research? I believe I had read this article back in 2017 and was so encouraged that maybe something new was on the horizon in dental treatment, but I haven't read anything. Interesting that some of the substances on the list to decrease GSK3B are very Peaty. I