Tianeptine Vs. Endotoxin

[LeeLemonoil]

Seems like Tianeptine is helpful for mood-disorders not least because anti-inflammatory actions directly in brain structures stemming from protection against LPS.



Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats. - PubMed - NCBI

Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways. - PubMed - NCBI

The latter publication was retracted, because of formal issues not the validity of the findings.

 

[Terma]

Yep it does just about everything. Its touted SERT effects have become misleading, because it does so much else. (sorry useless post too tired)

 

[Constatine]

Its starting to seem like anything that decreases serotonin and increases cell respiration protects against endotoxin.

 

[Terma]

Yeah, I still have chicken-or-the-egg questions about that, but one thing's for sure I've never gotten far targeting serotonin itself on myself so I tend to treat it as secondary as a bias.

 

[ddjd]

@haidut are you interested in doing a tianeptine product

 

[haidut]

@haidut are you interested in doing a tianeptine product

Not really. Google for "powdercity tianeptine".