Tianeptine Vs. Endotoxin

Discussion in 'Tianeptine' started by LeeLemonoil, Aug 29, 2017.

  1. LeeLemonoil

    LeeLemonoil Member

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    Seems like Tianeptine is helpful for mood-disorders not least because anti-inflammatory actions directly in brain structures stemming from protection against LPS.



    Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats. - PubMed - NCBI

    Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways. - PubMed - NCBI

    The latter publication was retracted, because of formal issues not the validity of the findings.
     
  2. Terma

    Terma Member

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    Yep it does just about everything. Its touted SERT effects have become misleading, because it does so much else. (sorry useless post too tired)
     
  3. Constatine

    Constatine Member

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    Its starting to seem like anything that decreases serotonin and increases cell respiration protects against endotoxin.
     
  4. Terma

    Terma Member

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    Yeah, I still have chicken-or-the-egg questions about that, but one thing's for sure I've never gotten far targeting serotonin itself on myself so I tend to treat it as secondary as a bias.
     
  5. ddjd

    ddjd Member

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    @haidut are you interested in doing a tianeptine product
     
  6. haidut

    haidut Member

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    Not really. Google for "powdercity tianeptine".
     
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