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Tianeptine Vs. Endotoxin

LeeLemonoil

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Sep 24, 2016
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2,768
Seems like Tianeptine is helpful for mood-disorders not least because anti-inflammatory actions directly in brain structures stemming from protection against LPS.



Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats. - PubMed - NCBI

Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways. - PubMed - NCBI

The latter publication was retracted, because of formal issues not the validity of the findings.
 

Terma

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May 8, 2017
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1,063
Yep it does just about everything. Its touted SERT effects have become misleading, because it does so much else. (sorry useless post too tired)
 

Constatine

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Sep 28, 2016
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1,782
Its starting to seem like anything that decreases serotonin and increases cell respiration protects against endotoxin.
 

Terma

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May 8, 2017
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1,063
Yeah, I still have chicken-or-the-egg questions about that, but one thing's for sure I've never gotten far targeting serotonin itself on myself so I tend to treat it as secondary as a bias.
 

haidut

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Mar 18, 2013
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