AretnaP
Member
- Joined
- Mar 27, 2017
- Messages
- 180
also excitotoxicity, but we already knew that. It also may be true that some free radicals can contribute to excitotoxicity.
Update of Cell Damage Mechanisms in Thiamine Deficiency: Focus on Oxidative Stress, Excitotoxicity and Inflammation | Alcohol and Alcoholism | Oxford Academic
"NO has the ability to disrupt the BBB (Au et al., 1985); since endothelial cells and astrocytes are important sources of NO (Murphy et al., 1990; Moncada et al., 1991), and free radicals are capable of increasing endothelial permeability in brain (Chan et al., 1984) and other tissues"
antioxidants (even though they weren't peaty) protected the BBB in this case:
"Further evidence in support of a role of oxidative stress in the pathogenesis of selective neuronal loss in TD is provided by the report of a neuroprotective effect of L-deprenyl (Todd and Butterworth, 1998), an agent with potent oxygen free radical scavenging properties. In addition, a preliminary report suggests that superoxide dismutase is increased in vulnerable brain regions and was reduced following treatment with L-deprenyl (Todd and Butterworth, 1997), while treatment with the antioxidant N-acetylcysteine protected against neuronal cell death (Hazell and Wang, 2005). Interestingly, L-deprenyl has been shown to cause a slowing in the evolution of the neurological deficits in Alzheimer's disease (Schneider et al., 1991), as well as Parkinson's disease (Oakes, 1993) another neurodegenerative disorder associated with decreased activities of KGDH."
Interesting miscellaneous things:
"Increased production of reactive oxygen species (ROS) has been reported in brain in TD (Langlais et al., 1997), and oxidative stress is related to the pathology in human WE as evidenced by increased neuronal peroxidase activity."
"it is likely that NO and peroxynitrite-mediated mitochondrial dysfunction and damage play a role in the pathogenesis of TD-related neuronal cell loss."
"In addition, oxidative stress can rapidly lead to inhibition of glutamate transport due to transporter protein nitrosylation by peroxynitrite formation"
BBB breakdown lead to increased iron in brain:
"previous studies have reported the presence of iron deposits in TD brain, in the form of both iron and ferritin"
Update of Cell Damage Mechanisms in Thiamine Deficiency: Focus on Oxidative Stress, Excitotoxicity and Inflammation | Alcohol and Alcoholism | Oxford Academic
"NO has the ability to disrupt the BBB (Au et al., 1985); since endothelial cells and astrocytes are important sources of NO (Murphy et al., 1990; Moncada et al., 1991), and free radicals are capable of increasing endothelial permeability in brain (Chan et al., 1984) and other tissues"
antioxidants (even though they weren't peaty) protected the BBB in this case:
"Further evidence in support of a role of oxidative stress in the pathogenesis of selective neuronal loss in TD is provided by the report of a neuroprotective effect of L-deprenyl (Todd and Butterworth, 1998), an agent with potent oxygen free radical scavenging properties. In addition, a preliminary report suggests that superoxide dismutase is increased in vulnerable brain regions and was reduced following treatment with L-deprenyl (Todd and Butterworth, 1997), while treatment with the antioxidant N-acetylcysteine protected against neuronal cell death (Hazell and Wang, 2005). Interestingly, L-deprenyl has been shown to cause a slowing in the evolution of the neurological deficits in Alzheimer's disease (Schneider et al., 1991), as well as Parkinson's disease (Oakes, 1993) another neurodegenerative disorder associated with decreased activities of KGDH."
Interesting miscellaneous things:
"Increased production of reactive oxygen species (ROS) has been reported in brain in TD (Langlais et al., 1997), and oxidative stress is related to the pathology in human WE as evidenced by increased neuronal peroxidase activity."
"it is likely that NO and peroxynitrite-mediated mitochondrial dysfunction and damage play a role in the pathogenesis of TD-related neuronal cell loss."
"In addition, oxidative stress can rapidly lead to inhibition of glutamate transport due to transporter protein nitrosylation by peroxynitrite formation"
BBB breakdown lead to increased iron in brain:
"previous studies have reported the presence of iron deposits in TD brain, in the form of both iron and ferritin"
