• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

The Thread For People Making Their Own Liquid Supplements (progest-e Etc.)

Joined
Nov 21, 2015
Messages
9,602
I want to make my own Progest-E version. I have tocopherols, I have MCT oil, I have progesterone powder.

how would I make a batch?
 

S-VV

Member
Joined
Jul 23, 2018
Messages
591
Heat the oil in a Pyrex glass. I do it Bain-Marie, but a Bunsen burner would serve just as well. Once the oil is hot, add the powder. Do this slowly to ensure full dissolution. Depending on the concentration you wish to achieve, you may have to stir with a magnetic stirrer or with a mechanical one, rather than by hand. Add the tocopherols while the oil is still hot. The volumes of the oil and tocopherols may not be additive, so more oil will be needed to adjust.

This is how I do my liquids. I do them with DMSO, ethanol and water, because oils just take too long to absorb and leave you sticky.
 

Mossy

Member
Joined
Jun 2, 2017
Messages
1,423
I want to make my own Progest-E version. I have tocopherols, I have MCT oil, I have progesterone powder.

how would I make a batch?
Would you mind sharing how this has gone for you? Also, could you share how you feel this compares to commercial versions? Thank you.
 
Joined
Jan 7, 2020
Messages
12
This is interesting, I have been thinking about this a lot lately and been looking around online as to how to go about doing this with Adrafinil and Tianeptine.

I'll see if I can turn anything up with this included in the searches, unless anyone here can provide insight to this matter :)
 
Joined
Jan 7, 2020
Messages
12
Awesome!! Let me know how it works out, this topic has my interest piqued! I'm wondering if the same method of what you are doing could be applied to other things (namely various powdered nootropics I have laying about lol)
 

Grapelander

Member
Joined
Mar 26, 2019
Messages
1,031
Location
Sonoma County
Dr Peat said Vitamin E just had to be warmed up to room temperature to mix with Progesterone.
Previously to that he used olive oil and needed to heat it up on the stove.

I've mixed CoQ10 with MCT oil. I just stirred together and put in fridge. It mixed in just fine.
 

Mossy

Member
Joined
Jun 2, 2017
Messages
1,423
@johnwester130 has shared that he's had success using the following recipe as a base to mix pregnenolone into. I would imagine that would work for other powdered hormone supplements; such as progesterone and DHEA:

20ml fractionated coconut oil
10ml ethyl alcohol.
 

Matestube

Member
Joined
Dec 28, 2021
Messages
690
Location
Dubai
I want to make my own Progest-E version. I have tocopherols, I have MCT oil, I have progesterone powder.

how would I make a batch?
How did it go?
Does the progesterone powder readily mixes with MCT oil only? Because testosterone absolutely doesn't.

These guys manage to reach 100mg/ml concentration with just progesterone, MCT oil and tocopherols:
 

ecstatichamster

Member
Thread starter
Joined
Nov 21, 2015
Messages
9,602
How did it go?
Does the progesterone powder readily mixes with MCT oil only? Because testosterone absolutely doesn't.

These guys manage to reach 100mg/ml concentration with just progesterone, MCT oil and tocopherols:

it works fine. I dissolve about 20mg of micronized progesterone into a teaspoon of MCT oil and it disappears and I swallow it occasionally. Nothing works as well for a stomach ache.
 

Peatness

Member
Joined
Oct 12, 2020
Messages
10,700
Dr Peat said Vitamin E just had to be warmed up to room temperature to mix with Progesterone.
Previously to that he used olive oil and needed to heat it up on the stove.

I've mixed CoQ10 with MCT oil. I just stirred together and put in fridge. It mixed in just fine.
Which CoQ10 did you use?
 

Matestube

Member
Joined
Dec 28, 2021
Messages
690
Location
Dubai
it works fine. I dissolve about 20mg of micronized progesterone into a teaspoon of MCT oil and it disappears and I swallow it occasionally. Nothing works as well for a stomach ache.
I tried again putting some raw progesterone powder in hot MCT oil, and it hardly dissolved.
I ordered some tocopherol oil to see of it mixes better.
 

ecstatichamster

Member
Thread starter
Joined
Nov 21, 2015
Messages
9,602
I tried again putting some raw progesterone powder in hot MCT oil, and it hardly dissolved.
I ordered some tocopherol oil to see of it mixes better.

my progesterone is from Suchlabs. Dissolved just fine, interesting!
 

Ponce

Member
Joined
Mar 23, 2019
Messages
20
I tried again putting some raw progesterone powder in hot MCT oil, and it hardly dissolved.
I ordered some tocopherol oil to see of it mixes better.
Can you tell us where you ordered your tocopherol oil ? Thanks !
 

Grapelander

Member
Joined
Mar 26, 2019
Messages
1,031
Location
Sonoma County
Which CoQ10 did you use?
I used the Pure Bulk powder. The reason I mixed with the MCT oil was to prevent oxidation.
Interesting that it hardens up in the fridge more than just the MCT alone (structured?).
I think if I make it again I will add Vitamin E - seems like CoQ10 needs it to work right:


"Current evidence suggests that ubiquinol and α-tocopherol act in concert to scavenge radicals during autoxidation of mitochondrial membranes (Kagan et al., 1990;Stoyanovsky et al., 1995;Lass and Sohal, 1998;2000;Sohal, 2004). α-Tocopherol seems to act as a direct scavenger forming tocopheroxyl radical, whereas ubiquinol reacts with tocopheroxyl radical to regenerate αtocopherol."
 

Peatness

Member
Joined
Oct 12, 2020
Messages
10,700
I used the Pure Bulk powder. The reason I mixed with the MCT oil was to prevent oxidation.
Interesting that it hardens up in the fridge more than just the MCT alone (structured?).
I think if I make it again I will add Vitamin E - seems like CoQ10 needs it to work right:


"Current evidence suggests that ubiquinol and α-tocopherol act in concert to scavenge radicals during autoxidation of mitochondrial membranes (Kagan et al., 1990;Stoyanovsky et al., 1995;Lass and Sohal, 1998;2000;Sohal, 2004). α-Tocopherol seems to act as a direct scavenger forming tocopheroxyl radical, whereas ubiquinol reacts with tocopheroxyl radical to regenerate αtocopherol."
Thank you
 

Similar threads

Top