The So-called "chemobrain" Condition May Be Due To Decreased Dopamine

haidut

Member
Joined
Mar 18, 2013
Messages
17,433
Location
USA / Europe
Many patients with cancer complain of brain fog, forgetfullness, confusion, and irritability. The condition has been called "chemobrain" as it often starts shortly after initiating chemotherapy sessions and thus fat medicine is baffled as to what causes it. Judging by the signs, I have always thought that the condition is probably related to serotonin/dopamine, and it looks like my guess may have been correct. This recent study found that dopamine release is dramatically lowered in chemotherapy patients, but unfortunately the authors do not go as far as recommending drugs for counteracting it. They also found that serotonin release is also impaired, but for some reason the focus of the study was still dopamine, presumably presumably because it plays such an important role in memory and cognition.

http://pubs.acs.org/doi/full/10.1021/acschemneuro.5b00029
ChemoBrain Linked to Decreased Dopamine Release - MedicalResearch.com

"...For this study, we wanted to understand how treatment with chemotherapeutic agents affects the ability of neurons to communicate. An impairment of neurotransmitter release would imply that communication is hindered. This inability to communicate normally could contribute to cognitive dysfunction.
We initially measured the release of dopamine in a region of the brain called the striatum. Our measurement of dopamine in this region was motivated by two key issues: its importance in cognitive function and our ability to measure it with high temporal resolution. From a cognitive standpoint, dopamine is important because the striatum helps translate signals, received from the cortex, into plans by forwarding wanted signals to other parts of the brain and suppressing unwanted signals. Fortunately, we can easily measure dopamine release using an electrochemical technique called fast-scan cyclic voltammetry. This method allows us to not only measure how much dopamine is released from a living brain slice, but also it affords us the capability to measure how quickly dopamine is taken back up. We also measured serotonin release using this method. Our main finding was that the ability of neurons to release dopamine was impaired after carboplatin treatment. We also found that serotonin release was similarly impaired. These release impairments corresponded to a decrease in cognitive ability of the treated rats."
 

DaveFoster

Member
Joined
Jul 23, 2015
Messages
4,920
Location
Spokane, Washington
Wouldn't lowered dopamine increase serotonin's effect? So regardless of serotonin's decrease, the decreased dopamine would allow for greater serotonergic transmission.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,433
Location
USA / Europe
Wouldn't lowered dopamine increase serotonin's effect? So regardless of serotonin's decrease, the decreased dopamine would allow for greater serotonergic transmission.

Absolutely. Dopamine (and dopamine) agonists inhibit TPH and this keep serotonin synthesis under control. The serotonergic and dopaminergic neurons also seem to inhibit each other's firing. So, less dopamine would lead to a stronger serotonergic tone, whether by more serotonin synthesis or more serotoninergic neuronal activity.
 
Similar threads
Thread starter Title Forum Replies Date
GorillaHead Why Is The So Called T-Zone On Our Face Even A Thing? Skin 2
Gadreel Has Alldaychemist Called You? Miscellaneous 17
Dan Wich KMUD: 12-20-2019 [Called Off] KMUD Radio-The Herb Doctors 0
ecstatichamster Anyone Familiar With The So-called "P-Shot" Sexuality 5
Mito Fast Food Increases Exposure To A 'forever Chemical' Called PFAS Articles & Scientific Studies 1
Dan Wich KMUD: 8-16-2019 [Called Off] KMUD Radio-The Herb Doctors 4
Dan Wich KMUD: 2-15-2019 [Called Off] KMUD Radio-The Herb Doctors 8
Herbie Alex Jones Sells Pregnenolone Tablets Called 'the Real Red Pill' Miscellaneous 3
Dan Wich KMUD: 7-20-2018 [Called Off] KMUD Radio-The Herb Doctors 2
Dan Wich KMUD: 4-20-2018 [Called Off] KMUD Radio-The Herb Doctors 3
Dan Wich KMUD: 2-16-2018 [Called Off] KMUD Radio-The Herb Doctors 4
D So Called 'Elevation Masks' Suitable For CO2 Increase? CO2, Bag Breathing 20
Westside PUFAs Fish Oil Should Really Be Called Fish Fat The Ray Peat Forum Lounge 5
S The Greeks Called That The Sin Of Hubris Rant or Rave 79
Westside PUFAs I'm So Embarrassed That I Ever Called Myself A "liberal." Political Talk, Alternative World Theories 334
Dan Wich KMUD: 9-18-2015 [called off] KMUD Radio-The Herb Doctors 1
Dan Wich KMUD: 4-17-2015 [called off] KMUD Radio-The Herb Doctors 10
haidut Stress (cortisol) Can Cause ANY Autoimmune Condition By Disrupting Gut Barrier Scientific Studies 0
Peatogenic Natural Antibiotic/Antiviral Regimen (autoimmune Condition Prevention) Ask For Help or Advice 9
haidut The (in)famous Condition “chemo Brain” May Be Simply A State Of Low DHEA Scientific Studies 0
lvysaur Lupus-bred Mice Are Completely Resistant To Their Condition In EFA Deficiency Fats 2
F Saturated Fat Does Not Clog The Arteries: Coronary Heart Disease Is A Chronic Inflammatory Condition Heart, Heart Rate, Blood Pressure 2
Mito Saturated Fat Does Not Clog The Arteries: Coronary Heart Disease Is A Chronic In Ammatory Condition Articles & Scientific Studies 2
haidut Human Study Confirms Alzheimer As A Metabolic Condition (brain Diabetes) Scientific Studies 22
haidut The Big Study On Curing Heart Condition Through Genetic Editing May Be Wrong Scientific Studies 3
A PLEASE HELP WITH MY SPECIFIC CONDITION Ask For Help or Advice 10
yerrag Thoughts And Advice On My Cat Condition Progressing From Hyperesthesia Towards Parkinson's Animals 20
yerrag Blood Test Results - Please Comment On My Condition Blood Work, Labs 111
haidut Delirium May Be An Inflammatory Reaction/condition Scientific Studies 4
D Can anyone help to define my thyroid condition??? Blood Work, Labs 40
M Perplexed over my condition Ask For Help or Advice 0
P Keratosis Pilaris (skin condition) anyone? Skin 19

Similar threads

Top