The Return Of Parabiosis

[haidut]

Ray wrote in his last newsletter about the differences in metabolic markers between old and young organisms, and how blood transfusions from young to old animals were used almost a century ago to reverse some symptoms of aging.
It looks like after its miserable failure in treating Alzheimer Disease (over 99% failure of new drug trials) the pharma industry is re-discovering those "old" techniques. According to this article we may soon see parabiotic therapies make a comeback.

http://sciencealert.com.au/news/20142108-26046.html

 

[jyb]

Could that be explained in terms of transfusion of younger, healthier more structured cells? They suggest instead its due to a plasma born moleculde "GDF11". (What about excess iron going in?)

 

[haidut]

Could that be explained in terms of transfusion of younger, healthier more structured cells? They suggest instead its due to a plasma born moleculde "GDF11". (What about excess iron going in?)

That was Ray's explanation as well. He said also the balance of hormones would be better in young blood (especially pregnenolone, progesterone, thyroid, etc) and it will contain mostly glucose and not toxic fatty acids and their by-products. I am sure there are tons of other factors as well that we don't know about yet.

 

[Such_Saturation]

I think it might be the NAD+, which refined would cost tens of thousands of dollars. I don't know why old rich guys aren't buying young blood by the gallon. It's almost like they know even less than we do.

 

[Parsifal]

post 54387 Ray wrote in his last newsletter about the differences in metabolic markers between old and young organisms, and how blood transfusions from young to old animals were used almost a century ago to reverse some symptoms of aging.
It looks like after its miserable failure in treating Alzheimer Disease (over 99% failure of new drug trials) the pharma industry is re-discovering those "old" techniques. According to this article we may soon see parabiotic therapies make a comeback.

http://sciencealert.com.au/news/20142108-26046.html

Why would the animals that we eat if they are young not good enough in that regard?

Also, have you heard about autohemotherapy? http://www.arizonaadvancedmedicine.com/ ... erapy.aspx
Reminds me a bit about Urine Therapy as well.

 

[haidut]

post 117741

post 54387 Ray wrote in his last newsletter about the differences in metabolic markers between old and young organisms, and how blood transfusions from young to old animals were used almost a century ago to reverse some symptoms of aging.
It looks like after its miserable failure in treating Alzheimer Disease (over 99% failure of new drug trials) the pharma industry is re-discovering those "old" techniques. According to this article we may soon see parabiotic therapies make a comeback.

http://sciencealert.com.au/news/20142108-26046.html

Why would the animals that we eat if they are young not good enough in that regard?

Also, have you heard about autohemotherapy? http://www.arizonaadvancedmedicine.com/ ... erapy.aspx
Reminds me a bit about Urine Therapy as well.

They would be, if we were eating them fresh. Ray said that fresh meat from a young animal has a lot of glycogen and protective steroids. However, most of the meat we buy from the store has been "aged" for months due to travel/storage, etc and by the time it reaches us it is devoid of most protective substances present in the young animal.

 

[Nikki]

Now "they" say GDF11 abundance is linked to aging. I don't quite believe it (it is much easier too fool a person than to convince her she has been fooled).

found on web:

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration.

Age-related frailty may be due to decreased skeletal muscle regeneration. The role of TGF-β molecules myostatin and GDF11 in regeneration is unclear. Recent studies showed an age-related decrease in GDF11 and that GDF11 treatment improves muscle regeneration, which were contrary to prior studies. We now show that these recent claims are not reproducible and the reagents previously used to detect GDF11 are not GDF11 specific. We develop a GDF11-specific immunoassay and show a trend toward increased GDF11 levels in sera of aged rats and humans. GDF11 mRNA increases in rat muscle with age. Mechanistically, GDF11 and myostatin both induce SMAD2/3 phosphorylation, inhibit myoblast differentiation, and regulate identical downstream signaling. GDF11 significantly inhibited muscle regeneration and decreased satellite cell expansion in mice. Given early data in humans showing a trend for an age-related increase, GDF11 could be a target for pharmacologic blockade to treat age-related sarcopenia.

https://www.ncbi.nlm...pubmed/26001423