methylenewhite
Member
- Joined
- Aug 21, 2018
- Messages
- 1,237
The Randle cycle revisited: a new head for an old hat
Inhibition of glucose utilization by fatty acids was originally demonstrated in heart (142). It was later also found in liver (13, 84) and in the β-cells of the pancreas, where a permissive effect of fatty acids on glucose-induced insulin secretion has been established (146). Interestingly, the cycle can be extended to lactate in heart and liver (36, 37, 39, 74, 169, 182), two lactate-consuming organs. Here, lactate inhibits the oxidation of both glucose and fatty acids. Much experimental evidence accumulated thus far confirms that the Randle cycle is actually working in whole animals as well as in humans (63, 64, 146).
This makes sense for me. Inability to oxidase both FA and glucose, this what creates failed energy utilization, some kind of lactate induced metabolic "bottleneck" creating vicious cycle. Does it mean that lactate issues should be the first target in restoring metabolic health?
@haidut Can I hear your opinion please?
Inhibition of glucose utilization by fatty acids was originally demonstrated in heart (142). It was later also found in liver (13, 84) and in the β-cells of the pancreas, where a permissive effect of fatty acids on glucose-induced insulin secretion has been established (146). Interestingly, the cycle can be extended to lactate in heart and liver (36, 37, 39, 74, 169, 182), two lactate-consuming organs. Here, lactate inhibits the oxidation of both glucose and fatty acids. Much experimental evidence accumulated thus far confirms that the Randle cycle is actually working in whole animals as well as in humans (63, 64, 146).
This makes sense for me. Inability to oxidase both FA and glucose, this what creates failed energy utilization, some kind of lactate induced metabolic "bottleneck" creating vicious cycle. Does it mean that lactate issues should be the first target in restoring metabolic health?
@haidut Can I hear your opinion please?