The Progest-E & Raw Honey High

[Rinse & rePeat]

View: https://youtu.be/UYj_wnocMgY

 

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"Caffeine synergizes with progesterone, and increases its concentration in blood and tissues." -Ray Peat

 

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Looks like "new researcher" is finally catching up to old science......

NHS UK to give progesterone to prevent miscarriage

This is somewhat of a positive, progesterone prescribed for miscarriage in the UK, let’s hope it’s bio identical, the brand is Utrogestan. https://www.tommys.org/about-us/charity-news/giving-some-pregnant-women-progesterone-could-prevent-8450-miscarriages-year-say-experts Researchers at...

raypeatforum.com

 

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Progesterone success stories (men)

Any male on here is taking progesterone with positive effects? Anecdotal experience from other forums seem to only be pointing to sexual castration and fat redistribution akin to women's. Granted they may be: 1) using too much 2) not using androgens along with progesterone My goal in using it...

raypeatforum.com

 

[Rinse & rePeat]

Maximum Reasonable Dose of Progesterone

What's the maximum reasonable dose of progesterone that can be used for a woman? I'm currently using Progestene topically, and I'm up to 36 drops (about 61 mg). I'm wondering if that's too much, and if I can increase it even more. It does help relax me, but I'm still having hot flashes during...

raypeatforum.com

 

[Rinse & rePeat]

"Problems that seem relatively trivial become more meaningful when they are seen in terms of these mechanisms. Some problems that become very common by middle age are "palpitations," orthostatic hypotension, orthostatic tachycardia, and varicose veins. The negative inotropic effect of estrogen in the heart has a parallel in the smooth muscle of veins, in which the muscles are weakened, and their distensibility increased, when estrogen isn't sufficiently opposed by progesterone. This allows the veins in the lower part of the body to be distended abnormally when standing, reducing the amount of blood returning to the heart, so that the volume pumped with each stroke is small, requiring faster beating. The reduced blood volume reaching the brain can cause fainting. When it becomes chronic, it can lead to the progressive distortion of the veins. An excess of estrogen is associated with varicose veins in men, as well as women." -Ray Peat

 

[Rinse & rePeat]

"One of the "estrogen receptors" appears to actively contribute to bone loss (Windahl, et al., 1999, 2001). Studies in dogs following the removal of their ovaries found that there was an increase of bone remodeling and bone formation rate in the first month, followed by a few months of slowed bone formation, but that by 10 months after the surgery the bones had returned to their normal remodeling rate, and that "at no time was a significant reduction in bone volume detected" (Boyce, et al., 1990). With the removal of the ovaries, the production of progesterone as well as estrogen is affected, but the adrenal glands and other tissues can produce those hormones." -Ray Peat

 

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"When estrogen was found to age the connective tissues, it was assumed that continual breeding during an animal's life-time, greatly increasing the total exposure of the tissues to estrogen, would increase the aged rigidity of the connective tissues, but these animals were found to have less rigid tissues. During pregnancy other hormones, especially progesterone, were also increased, and it was suggested that this reversed the effects of aging and estrogen. Since most people had believed that frequent pregnancies would cause a woman to age more rapidly, a large survey of records was done, to compare the longevity of women with the number of pregnancies. It was found, in the very extensive Hungarian records, that life-span was increased in proportion to the number of pregnancies.: -Ray Peat

 

[Rinse & rePeat]

View: https://youtu.be/GFyZnATVlmc

 

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"An increased mortality from accidents and suicide when cholesterol is lowered is reminiscent of the problems seen in progesterone deficiency, and it's very likely that a deficiency of the neurosteroids accounts for it. A deficiency of progesterone and other neurosteroids (the steroids synthesized by the nerves themselves) causes depression of mood and impaired learning ability, among other neurological changes. As was the case with cancer, the pharmaceutical industry continues to deny that their anticholesterol drugs cause suicide, depression, and dementia, but there is a large amount of evidence from human as well as animal studies showing that mood and intelligence are depressed by lowering cholesterol. Simply injecting cholesterol into animals can improve their learning ability. In the Framingham heart study of 1894 people extending over a period of about 20 years, people with cholesterol naturally in the "desirable" range, below 200 mg.%, scored lower on "verbal fluency, attention/concentration, abstract reasoning, and a composite score measuring multiple cognitive domains" than those with higher cholesterol (Elias, et al., 2005)." -Ray Peat

 

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"Many publications still promote estrogen as a cardioprotective drug, but there is now increased recognition of its role in heart failure and sudden cardiac death. A prolonged excited state (action potential) and delayed relaxation (QT interval) are known to increase the risk of arrhythmia and sudden death, and estrogen, which causes those changes in humans, causes sudden cardiac death in susceptible rabbits, with an adrenergic stimulant increasing the arrhythmias, and progesterone and androgen preventing them (Odening et al., 2012). Progesterone's protective effect seems to be the result of accelerating recovery of the resting state (Cheng, et al., 2012)." -Ray Peat

Heart and hormones

invoking the discredited 'wear and tear' theory of aging, could have many unexpected harmful consequences. It would reinforce existing misconceptions about heart functions.

raypeat.com

 

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"Although I don’t recommend “palm oil” as a food, because I think it is less stable than coconut oil, some studies show that it contains valuable nutrients. For example, it contains antioxidants similar to vitamin E, which lowers both LDL cholesterol and a platelet clotting factor. [B. A. Bradlow, University of Illinois, Chicago; Science News 139, 268, 1991.] Coconut oil and other tropical oils also contain some hormones that are related to pregnenolone or progesterone.” -Ray Peat

 

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"One of the things progesterone does is to stabilize blood sugar. In one experiment, hot flashes were found to be increased by lowering blood sugar, and decreased by moderately increasing blood sugar." Ray Peat

 

[Progesterone]

@Rinse & rePeat Is progesterone good to use for someone with an autoimmune disease?

the condition is called 'Eosinophilic fasciitis' (EF) is a syndrome in which tissue under the skin and over the muscle, called fascia, becomes swollen, inflamed and thick. The skin on the arms, legs, neck, abdomen or feet can swell quickly. The condition is very rare.

 

[Rinse & rePeat]

@Rinse & rePeat Is progesterone good to use for someone with an autoimmune disease?

the condition is called 'Eosinophilic fasciitis' (EF) is a syndrome in which tissue under the skin and over the muscle, called fascia, becomes swollen, inflamed and thick. The skin on the arms, legs, neck, abdomen or feet can swell quickly. The condition is very rare.

I personality think because progesterone is calming and protective it would be great. I think the biggest concern would be quality. I would not consider taking anything, but Progesterone-E, which Ray Peat has a patent on.

 

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@Rinse & rePeat Is progesterone good to use for someone with an autoimmune disease?

the condition is called 'Eosinophilic fasciitis' (EF) is a syndrome in which tissue under the skin and over the muscle, called fascia, becomes swollen, inflamed and thick. The skin on the arms, legs, neck, abdomen or feet can swell quickly. The condition is very rare.

Rinse & rePeat:
“Good morning Dr. Peat! My question is, progesterone beneficial for someone with an autoimmune disorder?”

RAY PEAT::
“Yes, for example lupus (SLE) and rheumatoid arthritis. Estrogen causes them.”

Rinse & rePeat:
“What about specifically Eosinophilic Fasciitis?”

RAY PEAT:
“Some of the known cases were caused by tryptophan supplements, and infections can cause it. When it’s caused by allergy and stress, then progesterone might help.”

 

[Rinse & rePeat]

@Rinse & rePeat Is progesterone good to use for someone with an autoimmune disease?

the condition is called 'Eosinophilic fasciitis' (EF) is a syndrome in which tissue under the skin and over the muscle, called fascia, becomes swollen, inflamed and thick. The skin on the arms, legs, neck, abdomen or feet can swell quickly. The condition is very rare.

He posted this below along with his e-mail answer….

Ann Rheum Dis. 1991 Jan; 50(1): 55–56.
Eosinophilic fasciitis associated with L-tryptophan ingestion.
M E Hamilton
A 62 year old woman taking L-tryptophan developed eosinophilic fasciitis shortly after starting an exercise class. She received prednisone without benefit but improved after azathioprine treatment was started and L-tryptophan was discontinued. As products containing L-tryptophan have recently been implicated in development of the eosinophilia-myalgia syndrome it is suggested that the use of L-tryptophan might have contributed to the development of eosinophilic fasciitis in this patient. Similarities with toxic oil syndrome are noted. Additional studies are warranted to determine the prevalence of L-tryptophan ingestion among patients diagnosed as having eosinophilic fasciitis.

https://rarediseases.org/rare-diseases/eosinophilic-fasciitis/EosinophilicFasciitis

NORD gratefully acknowledges Gerald J. Gleich, MD, Professor of Dermatology and Medicine, Department of Dermatology, University of Utah, for assistance in the preparation of this report.
General Discussion
Summary
Eosinophilic fasciitis is a rare disorder characterized by inflammation of the tough band of fibrous tissue beneath the skin (fascia). The arms and legs are most often affected. Inflammation is caused by the abnormal accumulation of certain white blood cells including eosinophils in the fascia. Eosinophilic fasciitis eventually causes the skin to swell and slowly thicken and harden (induration). The disorder most commonly affects middle-aged adults. The specific symptoms and severity of eosinophilic fasciitis can vary from one individual to another. The exact cause of eosinophilic fasciitis is unknown.

Introduction

Eosinophilic fasciitis, also known as Shulman syndrome, is named after the physician who, in 1974, was the first to report on the disorder in the medical literature. Some researchers believe that eosinophilic fasciitis is a variant of scleroderma (systemic sclerosis), an autoimmune connective tissue disorder characterized by hardening of the skin. However, these entities can usually be distinguished by their clinical characteristics.

Signs & Symptoms

Although researchers have been able to establish a clear syndrome with characteristic or “core” symptoms, much about eosinophilic fasciitis is not fully understood. Several factors including the small number of identified cases, the lack of large clinical studies, and the possibility of other unknown influencing factors prevent physicians from developing an accurate picture of associated symptoms and prognosis. Therefore, it is important to note that affected individuals may not have all of the symptoms discussed below.

The onset of eosinophilic fasciitis is often sudden (acute), developing over a few days or weeks. In these cases, the disorder may progress rapidly. Less often, a less severe form of disorder that progresses more slowly can develop. In many cases, an episode of eosinophilic fasciitis follows strenuous physical exercise or activity.

Specific symptoms and severity can vary greatly from one individual to another. Both sides of the body are affected in most cases, but rare cases where only one side of the body is affected have also been reported (unilateral eosinophilic fasciitis).

Initial symptoms associated with eosinophilic fasciitis include pain and swelling and inflammation of the skin, especially of the arms and legs. The arms and forearms are affected more often than the legs and thighs. The hands and feet are usually unaffected. Affected areas may initially become tender. Affected individuals may develop characteristic shallow grooves or furrows in the skin that run along the paths of underlying veins (venous grooving). Affected skin may become reddened (erythema) and warm and gradually thicken and harden (induration). Eventually, the skin may lose its elasticity and develop a characteristic woody, puckered, or orange peel texture. These progressive skin changes can potentially limit the mobility of the arms and legs. In some cases, the joints in the arms and legs may become stuck in unusual positions (contractures). Other areas that may be rarely affected include the face, abdomen, buttocks, and chest. In some cases, localized areas of scleroderma (morphea) may develop.

Some affected individuals may develop nonspecific symptoms including fatigue, weight loss, fever, and a general feeling of ill health (malaise) or a general lack of strength (asthenia). Although muscle strength is usually unaffected, muscle pain (myalgia) and inflammation of the joints (arthritis) often occurs. Bone pain has also been reported.

Some cases of eosinophilic fasciitis may be associated with carpal tunnel syndrome, a condition caused by compression of peripheral nerves affecting one or both hands. It is characterized by a sensation of numbness, tingling, burning and/or pain in the hand and wrist. Symptoms are slowly progressive and may eventually make it difficult to form a fist or grasp small objects.

The internal organs (viscera) may be affected in some cases, although only mildly. Blood (hematological) abnormalities have been reported including low levels of circulating red blood cells (anemia) and low levels of circulating platelets (thrombocytopenia). Anemia may cause tiredness, increased need for sleep, weakness, lightheadedness, dizziness, irritability, headaches, pale skin color, and difficulty breathing. Thrombocytopenia may cause individuals to be more susceptible to excessive bruising following minimal injury and to spontaneous bleeding from the mucous membranes, especially those of the gums and nose.

Causes

The exact cause of eosinophilic fasciitis is unknown (idiopathic). Researchers believe that the disorder results due to a nonspecific triggering event that causes an abnormal immune system response, specifically an abnormal allergic or inflammatory reaction. This abnormal response causes the overproduction and accumulation of eosinophils and other white blood cells in certain tissues of the body. The exact reason for this overproduction and accumulation is not fully understood.

Researchers have speculated that exposure to certain toxins, drugs such as simvastatin or phenytoin, or other environmental factors including infectious agents (Borrelia burgdorferi) may play a role in the development of eosinophilic fasciitis. Such environmental factors may be the underlying cause the abnormal inflammatory response in affected tissue.

Some scientists believe that eosinophilic fasciitis may be a variant of scleroderma or morphea (localized scleroderma). These rare disorders are characterized by the hardening and thickening of skin and surrounding tissue, often due to the malfunction of the immune system.
Some cases of eosinophilic fasciitis have been related to the ingestion of a dietary supplement known as L-tryptophan. Tryptophan is an essential amino acid found in numerous foods including poultry and was used as a sleep aid or to treat depression. In 1989 L-tryptophan ingestion was linked to an epidemic of a disorder known as eosinophilia-myalgia syndrome. (For more information on scleroderma, morphea or eosinophilia-myalgia syndrome, see the Related Disorders section of this report.)

Some reports suggest that eosinophilic fasciitis may be associated with extreme physical activity. Some cases developed following strenuous exercise (exercise-induced eosinophilic fasciitis). Trauma has also been associated with the disorder.

Some researchers believe eosinophilic fasciitis is one of several disorders that should be grouped under the designation fasciitis-panniculitis syndrome (FPS). Disorders under this designation are characterized by hardening and thickening of the skin due to inflammation and fibrosis.

In some cases, eosinophilic fasciitis can be associated with another disorder such as acquired aplastic anemia, hemolytic anemia, myelodysplastic syndromes, myeloproliferative disorders, lymphoma, leukemia, thyroid disorders, and primary biliary cirrhosis. The relationship between these disorders and eosinophilic fasciitis, if any, is not completely understood. (For more information on these disorders, choose the specific disorder name as your search term in the Rare Disorders Database.)