The Most Bizzare IBD Behavior. Smarties. Biohackers Thoughts?

rob

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@GorillaHead Regarding niacin putting your IBD in remission, do you just become assymptomatic or has testing (e.g. calprotectin levels) shown your inflammation normalising?

Only reason I ask is that I have Crohn's in my colon and had high inflammation but lack of overt symptoms many times before. Strangely, even my blood CRP doesn't pick up on my colonic inflammation. Calprotectin is the only thing that gives me a clue as to what is going on.
 
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GorillaHead

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@GorillaHead Regarding niacin putting your IBD in remission, do you just become assymptomatic or has testing (e.g. calprotectin levels) normalised as well?


My calproctin levels were low when I was symptomatic and even lower when I am asymptomatic. Also I have solved my problem even more by localizing niacin in the gut. I do this by Consuming Apple pectin supplements everyday. The preferential bacteria in my gut thrive on this and as an output produce naicin. I no longer dose naicin I’ve been doing great strictly on pectin. I can eat whatever. Even milk I take larger doses of pectin on those milk days. My symptoms all manifested the day I was pounding protein shakes and mass gainers everyday. For months
 

rob

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My calproctin levels were low when I was symptomatic and even lower when I am asymptomatic. Also I have solved my problem even more by localizing niacin in the gut. I do this by Consuming Apple pectin supplements everyday. The preferential bacteria in my gut thrive on this and as an output produce naicin. I no longer dose naicin I’ve been doing great strictly on pectin. I can eat whatever. Even milk I take larger doses of pectin on those milk days. My symptoms all manifested the day I was pounding protein shakes and mass gainers everyday. For months

Really happy to hear that. Thanks for the insight on the pectin.
 
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GorillaHead

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Really happy to hear that. Thanks for the insight on the pectin.
Of course I am hoping a diet rich of quality fiber like pectin will eventually shift me back to the healthier state I was in. I feel like I caused an offset of something.

I remember Haidat said that IBD is not autoimmune it’s strictly caused by bacterial or fungi. I agree with this 100%. I have taken antibiotics that made things worse! Bacteria is big deal here
 

rob

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I had a major turnaround end of last year when I started heavily dosing nicotinamide riboside (NR) for the NAD+ benefits. Thought I had a bioenergetics issue principally excerbated by stress/overexcitment – had signs of high adrenaline for ages prior to my IBD diagonsis. Also, subsequent reading has made me aware of how stress/CRH increases intestinal permeability via mast cell activation in the gut.

Personally, I think the increased intestinal permeability (casued by such a mechanism) is what sets the stage for bacterial translocation and reactions to food antigens. Of course, that then sets off the immune system, damages tissue and the inflammation dominoes.

Think the prostaglandin angle on niacin though is fascinating and somewhat ironic of this forum given its omega 6 mediated. Also, impressive that you took the niacin and the results lasted. I'm afraid of getting off NR in case my Crohn's comes back.
 
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GorillaHead

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I had a major turnaround end of last year when I started heavily dosing nicotinamide riboside (NR) for the NAD+ benefits. Thought I had a bioenergetics issue principally excerbated by stress/overexcitment – had signs of high adrenaline for ages prior to my IBD diagonsis. Also, subsequent reading has made me aware of how stress/CRH increases intestinal permeability via mast cell activation in the gut.

Personally, I think the increased intestinal permeability (casued by such a mechanism) is what sets the stage for bacterial translocation and reactions to food antigens. Of course, that then sets off the immune system, damages tissue and the inflammation dominoes.

Think the prostaglandin angle on niacin though is fascinating and somewhat ironic of this forum given its omega 6 mediated. Also, impressive that you took the niacin and the results lasted. I'm afraid of getting off NR in case my Crohn's comes back.


It’s possible it could come back. My naicin dosing put me in long periods of remission but symptoms would crop back up right after.. sometimes months. Sometimes two weeks after stopping naicin dosing. Which told me I was only temporarily treating the issue. Your gut needs to be modulated somehow. For me the only thing that I know that is highly dynamic in our gut is the bacteria. The bacteria needs to be altered And u can’t do it with probiotics. Only prebiotics. 3 weeks ago I had rhinoplasty and they gave me 5 day course of augmetin antibiotic. I was so scared that it would take me out of remission. So I figured if I am gonna kill tons of bacteria I might as well try my best to feed the good ones with pectin. So I took so much pectin. I think by nuking all bacteria but also helping the good ones at the same time I could’ve shifted things more in my favor. Who knows. But stools are excellent.

the year of my diagnosis besides the processed whey protein consumption, I had dosed lots of antibiotics and I was 6 months into my first adderall prescription. It’s clear to me that all these have played a factor in my development of the disease. There was a case where adderall caused colitis in a women and when she stopped it went away. The drug messes with serotonin and I know for a fact that serotonin has a big part to play here, naicin has a huge impact on serotonin as well.

bacteria —-serotonin- prostaglandins- mast


somewhere between all these is the perfect. Formula to solving this problem
 
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rob

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Interesting about the adderall, I've had significant ADHD symptoms since childhood, which have gone officially untreated. Think that's why my nervous system is in a mess. Do know that pyschological stress causes significant adverse changes to the microbiome.

Will explore the apple pectin further. The beta-glucans in oats seem to agree with me super well but, strangley, all other wholegrains have been murder for my Crohn's.

Btw, just curious, but wouldn't the anti-flushing action of the apple pectin counteract niacin's PGD2 production-mediated IBD benefits?? Or doesn't it affect the mechanism in the gut, just the facial flushing?
 
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GorillaHead

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Interesting about the adderall, I've had significant ADHD symptoms since childhood, which have gone untreated. Think that's why my nervous system is in a mess. Do know that pyschological stress causes significant adverse changes to the microbiome.

Will explore the apple pectin further. The beta-glucans in oats seem to agree with me super well but, strangley, all other wholegrains have been murder for my Crohn's.

Btw, just curious, but wouldn't the anti-flushing action of the apple pectin counteract niacin's PGD2 production-mediated IBD benefits?? Or doesn't it affect the mechanism in the gut, just the facial flushing?

Great question but honestly I am unsure. So much to learn. Give it a try see what it does for you. Past 2-3 years I spent like 6000 dollars on random supplements herbs. U name it experimenting over and over trying to find the solution.
 

rob

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Great question but honestly I am unsure. So much to learn. Give it a try see what it does for you. Past 2-3 years I spent like 6000 dollars on random supplements herbs. U name it experimenting over and over trying to find the solution.

Yes, same, spent ridiculous sums on supplements promising all sorts. Likewise, stressed myself with all sorts of diets that did nothing.
 

rob

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Interesting to note, according to this study Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. - PubMed - NCBI nicotinic acid is an agonist for the GPR109A receptor, which would normally be activated by the butyrate and niacin produced by our commensal bacteria. This receptor seems to be key to suppressing colonic inflammation.

Therefore, exogenous nicotinic acid seems a neat workaround to activate the receptor and calm inflammation in the immediate. Whereas, long term, improving the gut bacteria and increasing endogenous butyrate seems the ideal strategy.

Seems like your spot on @GorillaHead :)
 

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rob

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What kind of doses are you taking?

As of today, I’m at 1 gram (8 capsules) of TruNiagen - split evenly between the morning and afternoon. Apart from that, I’m currently taking MSM, taurine and l-theanine.

NR is expensive stuff, so interested to try nicotinic acid to see how I react to it. GorillaHead’s apple pectin idea also look likes a good shout for modulating bacteria and inflammation long term.

N.B. Sorry, forgot to say I’ve also added a little bit of TMG alongside the NR recently, as per Chris Masterjohn’s logic. Nothing negative prompted this just thought it might be wise as been taking it for a while.
 
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charlie

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As of today, I’m at 1 gram (8 capsules) of TruNiagen - split evenly between the morning and afternoon. Apart from that, I’m currently taking MSM, taurine and l-theanine.
Thank you sir. :hattip

interested to try nicotinic acid to see how I react to it.
I have posted a few things about niacin recently:

Niacin - Intestinal Permeability And Oxidative Stress In Patients With Alcoholic Pellagra

SIBO, GERD, LPR, IBS, & Colitis Could Be Vitamin B3 Deficiency - "Niacin Treats Digestive Problems"

Niacin Ameliorates Ulcerative Colitis

A Differential Diagnosis: How Pellagra Can Be Confused With Celiac Disease
GorillaHead’s apple pectin idea also look likes a good shout for modulating bacteria and inflammation long term.
I tried it and it wrecked me. :( Got the worst bloating ever and still trying to manage it. Maybe I should have kept going, I dunno, but it was bad enough to abort mission.
 

rob

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Thank you sir. :hattip


I have posted a few things about niacin recently:

Niacin - Intestinal Permeability And Oxidative Stress In Patients With Alcoholic Pellagra

SIBO, GERD, LPR, IBS, & Colitis Could Be Vitamin B3 Deficiency - "Niacin Treats Digestive Problems"

Niacin Ameliorates Ulcerative Colitis

A Differential Diagnosis: How Pellagra Can Be Confused With Celiac Disease

I tried it and it wrecked me. :( Got the worst bloating ever and still trying to manage it. Maybe I should have kept going, I dunno, but it was bad enough to abort mission.

Many thanks for the links.

Interesting response to the pectin. I remember taking resistant starch once for it’s supposed gut health benefits and it caused me agony, even at small doses.

I think it depends what state your intestines in. Get inflammation down first for a period of time - through nicotinic acid, NR or whatever - and then work in fibres depending on what your body agrees with. As said, for whatever reason, my body seems to really agree with oats but other fibres cause a lot of issues.
 
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GorillaHead

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As of today, I’m at 1 gram (8 capsules) of TruNiagen split evenly between the morning and afternoon. Apart from that, I’m currently taking MSM, taurine and l-theanine.

NR is expensive stuff, so interested to try nicotinic acid to see how I react to it. GorillaHead’s apple pectin idea also look likes a good shout for modulating bacteria and inflammation long term.


I hope it works you man. Although I have to admit I have come to conclude the cause Of ones IBD May differ from person to person. I legit am pretty passionate about this stuff.

hell I was almost ready to buy a few lab rats feed them exact same antibiotics I had. and then have a control group and then a group that strictly ate mass gainer and milk. Then another group that ate mass gainer and milk plus amphetamines. Lol. See if I could replicate
@charlie Btw, have you tried nicotinic acid?

Ultra-high dose of mesalamine to treat steroid-dependent ulcerative colitis

Even more interesting research. So my plan was to use mesalamine to increase reward sensitivity
 

rob

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I hope it works you man. Although I have to admit I have come to conclude the cause Of ones IBD May differ from person to person. I legit am pretty passionate about this stuff.

hell I was almost ready to buy a few lab rats feed them exact same antibiotics I had. and then have a control group and then a group that strictly ate mass gainer and milk. Then another group that ate mass gainer and milk plus amphetamines. Lol. See if I could replicate


Ultra-high dose of mesalamine to treat steroid-dependent ulcerative colitis

Even more interesting research. So my plan was to use mesalamine to increase reward sensitivity

Yeah, think we’re on the same page. Wasn’t quite at buying lab rat stage but done mountains of research on possible neurogenic and bioenergetic underpinnings, and gone through plenty of failed experiments. Also heartedly agree that one persons IBD can be different to anothers - they’ve certainly induced symptoms in animals in a variety of ways. Though it has been interesting to hear of others, like yourself, that have seen benefit from B3.

Personally, I think the brain/nervous system plays a big part in my disease - thought PEA supplements looked interesting on this front recently. Indeed, I see they’ve had success in calming down people’s IBD with vagus nerve implants.

It’s a complex thing and a subject that requires an understanding of the whole system. That’s my problem with specialists like my current gastro: they see and treat the intestines, not the wider system.

Interesting on the mesalamine. However, it quickly caused me bad drug-induced liver inflammation, so they had to pull it. The meds have been pretty useless for me generally, bar one stint early on in hospital with horse doses of IV hydrocortisone but, obviously, is less than ideal.
 

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