The JCV uses a serotonin receptor to infect cells


Mar 18, 2013
USA / Europe
The JCV is the potantial cause of the dreaded PML condition, which may effect people with "autoimmune" conditions (MS, lupus, rheumatoid arthritis) receiving immune-suppresive therapy. It looks like the JCV requires the 5-HT2 receptor for successful cell infection and 5-HT2 antagonists may block the virus' propagation. Yet another good use for cyproheptadine. More importantly, I wonder how many other viruses require a serotonin "receptor" for successful infection and if cyproheptadine can be a viable general-purpose antiviral drug. ... 0.abstract

"...The human polyomavirus, JCV, causes the fatal demyelinating disease progressive multifocal leukoencephalopathy in immunocompromised patients. We found that the serotonergic receptor 5HT2AR could act as the cellular receptor for JCV on human glial cells. The 5HT2A receptor antagonists inhibited JCV infection, and monoclonal antibodies directed at 5HT2A receptors blocked infection of glial cells by JCV, but not by SV40. Transfection of 5HT2A receptor–negative HeLa cells with a 5HT2A receptor rescued virus infection, and this infection was blocked by antibody to the 5HT2A receptor. A tagged 5HT2A receptor colocalized with labeled JCV in an endosomal compartment following internalization. Serotonin receptor antagonists may thus be useful in the treatment of progressive multifocal leukoencephalopathy."
Similar threads
Thread starter Title Forum Replies Date
S-VV Absolutely WILD wikipedia article (uses G. LING as a reference) Scientific Studies 3
J Exercise diverts calories away from non-productive uses like excessive inflammation? Exercise 1
Lokzo Bromantane: Permanently Increase Motivation? (Nootropic, Effects, Benefits & Uses) Supplements, Pharmaceutical Drugs 0
Soren Celliant, Material That Uses Body Heat To Create Near Infrared Light Mind, Sleep, Stress 4
S Who Here Uses Red Light Therapy? Experiments 0
David PS Pantothenic Acid For Acne Vulgaris And Other Patented Uses Supplements, Pharmaceutical Drugs 1
Giraffe Uses Of Urea - KMUD, 2015-02-20 Audio Interview Transcripts 1
scarlettsmum Theanine, Taurine, Lysine Uses Supplements, Pharmaceutical Drugs 22
Makrosky Medicinal uses of L-Lysine Articles & Scientific Studies 5
M Hillary Clinton Uses Armour Thyroid Breaking News 26
Dan Wich KMUD: 2-20-15 Uses Of Urea KMUD Radio-The Herb Doctors 119
S Chicken Farmer Uses Oregano Oil, Cinnamon in Place of Antibiotics Miscellaneous Health Discussions 6
haidut High (extracellular) serotonin causes Alzheimer's and depression Scientific Studies 13
JamesGatz Laughing increases serotonin and seems to increase Nitric Oxide ? Miscellaneous 3
BiduleMachin Anti-Peat Why I want opiates if serotonin is bad ? Debate - Anti-Peat 13
Lokzo 💎METERGOLINE: Dopamine Agonist, Serotonin Antagonist: Experiences Wanted Here! Supplements, Pharmaceutical Drugs 25
Oraganic4me Serotonin the cancer promoting hormone haidut 5
D Need help finding studies showing serotonin is dopamine antagonist/lowers dopamine Cortisol, Serotonin, Histamine 10
haidut Lowering/blocking serotonin is therapeutic for cancer Scientific Studies 2
miquelangeles Serotonin derivatives, phytoserotonin Cortisol, Serotonin, Histamine 7
J Damaged Gut, High Serotonin, Standard protocols dont work Cortisol, Serotonin, Histamine 9
G Anyone have a few infographics on serotonin and endotoxins? Digestion, Gut Flora 3
L Does gynostemma Lower serotonin just like ginseng Supplements 0
K What have you noticed by increasing dopamine and decreasing serotonin? Cortisol, Serotonin, Histamine 8
haidut Serotonin puts the brakes on libido, by lowering dopamine Scientific Studies 1
Drareg Regulation of systemic energy homeostasis by serotonin in adipose tissues Scientific Studies 0
Hans How to increase dopamine and lower serotonin with this simple, yet effective stack and food recipe Articles & Scientific Studies 33
RenaissanceMan Peat Wrong About Omega 3? DHA & EPA increase dopamine and lower serotonin Polyunsaturated Fats, Seed Oils 22
milkboi Safest drugs/substances to experience what Serotonin feels like? Autism 18
A Amino acid stack to deplete serotonin? Ask For Help or Advice 16
A Serotonin depletion stunts growth? Ask For Help or Advice 2
P Based serotonin video Cortisol, Serotonin, Histamine 1
Mauritio Serotonin, PUFA and histamine increase leaky brain Articles & Scientific Studies 6
Hans Milk: pro-dopamine or pro-serotonin? Scientific Studies 78
L Uridine And serotonin Supplements, Pharmaceutical Drugs 4
Hans Georgi Dinkov on aromatase inhibition, Gonadin+, testosterone optimization and serotonin antagonism Interviews 31
L Does adenosine triphosphate Lower serotonin Cortisol, Serotonin, Histamine 6
R Is there an interaction between serotonin and the angiotensin system in relation to coronavirus infection? Cortisol, Serotonin, Histamine 5
F Serotonin too LOW due to antihistamines for long periods? Cortisol, Serotonin, Histamine 7
Lokzo Guanosine dose-dependently reduced 5-HTP-induced wet dog shakes (WDS) and other Serotonin Syndromes Supplements, Pharmaceutical Drugs 2
S Premature ejaculation without Serotonin toxicity ? Male Issues 4
haidut Upregulated serotonin synthesis may be a biomarker for breast cancer Scientific Studies 0
haidut Depression fades away when serotonin levels drop Scientific Studies 4
haidut Many people may suffer from chronic serotonin syndrome Scientific Studies 65
haidut Serotonin and oxytocin promote gullibility, trainability, and servility Scientific Studies 4
Hans Serotonin dubs thee sleepless Articles & Scientific Studies 2
F Anxiety, overthinking, worrying, OCD might be caused by undermethylation or LOW serotonin? Mental Issues 1
F Anxiety, overthinking, worrying and pessimism caused by undermethylation or LOW serotonin? Cortisol, Serotonin, Histamine 17
sibyloftherhine Stingray venom contains serotonin Cortisol, Serotonin, Histamine 0
A Serotonin Activates Bacterial Quorum Sensing and Enhances the Virulence of Pseudomonas aeruginosa in the Host Cortisol, Serotonin, Histamine 44

Similar threads