ThinPicking
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- Sep 9, 2019
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The study below seems to confirm a bizarre phenomenon I frequently experience when taking a homemade Taurine supplement. I'm posting it here as it may assist others in receiving the maximum benefit from any naturopathic supplements or synthetic drugs you may be taking. It's often said that supplements and drugs should be taken on an "empty stomach" but given the calorie recommendations around the RP lifestyle it's probably rare the stomach would ever be completely empty.
I noticed this with Taurine because I can sense its effect. At some point I realised that taking small amounts with tiny sips of fluid was more effective than commercially available supplements of 500 mg and above. So I switched to making size 4 capsules that contain a low dose of about 100 mg to achieve the same effect.
I don't think I'm allowed to post SciHub links here. Please drop the DOI link below into SciHub if this is of any interest to you.
Abstract
Gastric muscle contractions grind and mix solid/liquid meal within the stomach, and move it into the bowels at a controlled rate. Contractions are of two types: slow volume-reducing contractions of the proximal stomach (the fundus), and peristaltic contraction waves in the distal stomach (the antrum). Fundic squeeze maintains gastro-duodenal pressure difference to drive gastric emptying. Emptying is generally assumed to proceed from the antrum to the fundus, so that ingested drugs can take hours to enter the small intestines and activate. Antral contraction waves (ACW), in contrast, generate fluid motions that break down and mix gastric content. Using a computer model of the human stomach, we discover a new function of these contraction waves apart from grinding and mixing. In coordination with fundic contraction, antral contraction waves move liquid content from the fundus along a very narrow path to the duodenum through the center of the antrum. Using physiological data, we show that this gastric emptying “Magenstrasse” (stomach road) can funnel liquid gastric content from the farthest reaches of the fundus directly to the intestines within 10 min. Consequently, whereas drugs (tablets, capsules, liquid) released off the Magenstrasse may require hours to enter the duodenum, at low concentration, when released on the Magenstrasse the drug can enter the duodenum and activate within 10 min—at high concentration. This discovery might explain observed high variability in drug initiation time, and may have important implications to both drug delivery and digestion, as well as to other wall-driven emptying of elastic containers.
I noticed this with Taurine because I can sense its effect. At some point I realised that taking small amounts with tiny sips of fluid was more effective than commercially available supplements of 500 mg and above. So I switched to making size 4 capsules that contain a low dose of about 100 mg to achieve the same effect.
I don't think I'm allowed to post SciHub links here. Please drop the DOI link below into SciHub if this is of any interest to you.
Redirecting
doi.org
Abstract
Gastric muscle contractions grind and mix solid/liquid meal within the stomach, and move it into the bowels at a controlled rate. Contractions are of two types: slow volume-reducing contractions of the proximal stomach (the fundus), and peristaltic contraction waves in the distal stomach (the antrum). Fundic squeeze maintains gastro-duodenal pressure difference to drive gastric emptying. Emptying is generally assumed to proceed from the antrum to the fundus, so that ingested drugs can take hours to enter the small intestines and activate. Antral contraction waves (ACW), in contrast, generate fluid motions that break down and mix gastric content. Using a computer model of the human stomach, we discover a new function of these contraction waves apart from grinding and mixing. In coordination with fundic contraction, antral contraction waves move liquid content from the fundus along a very narrow path to the duodenum through the center of the antrum. Using physiological data, we show that this gastric emptying “Magenstrasse” (stomach road) can funnel liquid gastric content from the farthest reaches of the fundus directly to the intestines within 10 min. Consequently, whereas drugs (tablets, capsules, liquid) released off the Magenstrasse may require hours to enter the duodenum, at low concentration, when released on the Magenstrasse the drug can enter the duodenum and activate within 10 min—at high concentration. This discovery might explain observed high variability in drug initiation time, and may have important implications to both drug delivery and digestion, as well as to other wall-driven emptying of elastic containers.
