The Fat-soluble Vitamins (K, A, D, E) May Be A Novel Treatment For Osteoarthritis (OA)


Mar 18, 2013
USA / Europe
Very preliminary research but still promising to see medicine look at vitamins as a possible treatment option for OA.

Fat-Soluble Vitamins Can Play Role in Managing Osteoarthritis
Role of Fat-Soluble Vitamins in Osteoarthritis Management : JCR: Journal of Clinical Rheumatology

"...Osteoarthritis (OA) is a chronic degenerative joint disease, in which metabolic imbalance in bone is observed. The pathological mechanism of metabolic imbalance is not clear yet, but the nutritional factors, particularly the vitamins, might be intrinsic to the development and progression of OA. In this review article, we have explored databases such as PubMed, Scopus, and Google Scholar articles until the beginning of 2017 and reviewed the role of fat-soluble vitamins in pathological and therapeutic aspects of OA. Vitamin D plays an important role in the development and maintenance of the skeleton, as well as bone and cartilage metabolism, and its deficiency is implicated in the pathological process of OA. Vitamin E enhances chondrocyte growth and exhibits an anti-inflammatory activity, as well as plays an important role in the prevention of cartilage degeneration. In human OA cartilage, vitamin K deficiency produces abnormal growth plate calcification and inappropriate mineralization of cartilage. Thus, these fat-soluble vitamins play a key role in the pathophysiology of OA, and supplementation of these vitamins may provide innovative approaches for OA management."
Similar threads
Thread starter Title Forum Replies Date
J Taking Fat Soluble Vitamins Supplements On The Same Days In The Week Or Separating Them Apart? Vitamins 2
D How To Best Obtain Fat-Soluble Vitamins Vitamins 1
B Do Vitamin D And Other Fat Soluble Vitamins Improve Or Worsen Autoimmunity? Ask For Help or Advice 6
milkboi MCTs Sufficient For Hormone Synthesis And Absorption Of Fat-soluble Vitamins On Low PUFA & Fat Diet Fats 28
SneezeStar Type Of Fat To Absorb Fat Soluble Vitamins Fat-Soluble Vitamins 5
milk_lover What Are Your Best Fat Soluble Vitamins Combinations From Personal Experience? Fat-Soluble Vitamins 5
A Can You Overdo Fat Soluble Vitamins If. K 2
F Absorption rate of fat-soluble vitamins through the skin? Supplements, Pharmaceutical Drugs 1
J My Fat Soluble Vitamins Approach Logs 3
berk Excess Fat Soluble Vitamin Cause Weight (fat) Gain? Diet 11
ecstatichamster Fat Soluble Vitamin C C 5
S Fat-Soluble Vitamins 0
J Water Soluble Vitamin A Is 10 Times As Toxic As Fat-soluble Scientific Studies 29
Frankdee20 Low Fat versus Low Carb for Weight Loss ? Diet 42
ddjd why does saturated fat + carbs make me fat?? Ask For Help or Advice 53
Herbie Saturated fat protects alcoholics, so why not drink more? Alcohol, Tobacco, Drugs 14
P how to separate fat from milk? Diet 3
Q Antibiotics to improve digestion and fat absorption (c diff without toxins) Digestion 0
J High Saturated Fat/Cholesterol Causes Clogged Pores/Sebaceous Filaments Skin 7
Highserotonin90 Fat Loss And FAO Inibhitors Ask For Help or Advice 2
Hgreen56 Salt, Sugar, And Dietary Fat Trigger Opioids In The Brain Which Can Contribute To Overeating Diet 4
U What's Worse High Fat No Starch Or Low Fat Higher Starch? Diet 12
J Fat And "LOW" Estrogen/low Libido After Andro/pansterone/VitE Ask For Help or Advice 28
S The Key To Low Body-fat, Regardless Of Diet/Exercise? Diet 28
J The Low-Fat Era - A Big Fat Lie? Diet 5
Hgreen56 When Dietary Fat Intake Falls Below 10% Of Total Daily Calories, You’ll Still Gain Fat Diet 45
TheSir Saturated Fat Causes Heart Disease. If You Are Hypothyroid Fats 24
E Does Coffee Make You Fat And Anxious? Miscellaneous 5
Sscobalt High Carb Moderate Protein Low Fat? Diet 37
Lokzo 5-Amino-1MQ Increases Energy, Fat Loss & Strength Supplements, Pharmaceutical Drugs 17
J How Much Dietary Fat Do You Actually Need For Hormones? Thyroid and Hormones 18
Yggr Body Fat Distribution Metabolism 4
J How Nutritious Is Animal FAT Really? Diet 9
A Visceral Fat Due To Impaired Metabolism/Fatty Liver Digestion 0
U High Fat Quality Goat Milk Or Low Fat Store Milk? Diet 9
Harryedgar Fat Loss, PUFA, Estrogen Detox And Increased Metabolism Weight 0
U Does Anybody Else Experience Significant Mood Changes On High (er) Fat Diet? Diet 27
Hgreen56 Eat No More That 1 Tsp Fat With A Meal To Prevent Inhibition Of The Oxidative Burning Of Sugar? Fats 1
Hans Fat Up The Health Benefits With Dairy Fat Articles & Scientific Studies 23
N Anti-Peat Saturated Fat TERRIBLE For Liver Health & Diabetes. Compared To PUFA Debate - Anti-Peat 140
md_a Ray Peat Interview Dr. Ray Peat - Iodine, Spider Veins, Oxalates, Fat Loss 2020-07-31 Jodellefit 0
Energizer Ray Peat Interview Get Fit With Jodelle - Iodine, Spider Veins, Oxalates, Fat Loss (July 31) Interviews 26
Harryedgar This Seems Weird! - Tryptophan Apparently Increases Fat Loss? Amino Acids 7
M Ray Peat Is Fine With Up To 30% Of Calories From Saturated Fat Macros & Micros 47
meatbag High-protein Diet Reduces Hepatic Fat Than Low-protein Diet Articles & Scientific Studies 0
Twohandsondeck Is The Fat Content Of Grain-fed Milk More Estrogen Than Grass-fed? Milk 0
Hgreen56 Rinsing Beef Reduced Fat Content But With Extra Oil Helps "suck" The Extra Fat Out Of The Beef? Diet 0
lvysaur Thymus Function: Higher In The Young/fat/female/Asian Scientific Studies 9
ScurveDream K2 Blend Won't Dissolve Properly In Fat Ask For Help or Advice 6
Cecilia L. Fat Loss - CorTinon 8:1 Weight 12

Similar threads