the extremely intelligent/autistic phenotype

redsun

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Wow, thanks for letting me know about this condition; describes me to a tee!

UndermethylationSymptomsandTraits.jpg


Does anyone have any thoughts on rectifying these issues?

Calcium intake is supposed to release histamine and reduce stores. Methionine/SAM-e will reduce histamine by deactivating it via methylation (way more effective). Vitamin C also helps by increasing adrenal activity (norepinephrine and epinephrine) which can help reduce release of histamine from mast cells. Copper does the same and also needed for DAO.

Ideally, increased copper and vitamin C intake from the right foods such as certain tropical fruits which are high in copper, liver, dark chocolate, potatoes etc can help increase norepinephrine/epinephrine which increases sympathetic activity. Through certain adrenergic receptors (I believe beta-2), they can inhibit mast cell release of histamine.

Low cortisol can also make the problem worse because it controls immune response. Really the problem comes only with some histadelics. Its when their adrenal activity drops really low, thus histamine is not controlled well. So most are pretty good and have little issues relatively, they are driven because of it. If it is so severe that adrenal activity is nonexistent that's where the problem lies. Excess stress can do it, and of course some are more prone depending on diet.

Methionine/SAM-e reduces the histamine load effectively for severe cases.

Increasing vitamin C and copper intake is an easy step and may be all you need to control it. If its not helping much, I suggest you try 200-400mg SAM-e to see how it affects you.
 

Ignoramus

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Calcium intake is supposed to release histamine and reduce stores. Methionine/SAM-e will reduce histamine by deactivating it via methylation (way more effective). Vitamin C also helps by increasing adrenal activity (norepinephrine and epinephrine) which can help reduce release of histamine from mast cells. Copper does the same and also needed for DAO.

Ideally, increased copper and vitamin C intake from the right foods such as certain tropical fruits which are high in copper, liver, dark chocolate, potatoes etc can help increase norepinephrine/epinephrine which increases sympathetic activity. Through certain adrenergic receptors (I believe beta-2), they can inhibit mast cell release of histamine.

Low cortisol can also make the problem worse because it controls immune response. Really the problem comes only with some histadelics. Its when their adrenal activity drops really low, thus histamine is not controlled well. So most are pretty good and have little issues relatively, they are driven because of it. If it is so severe that adrenal activity is nonexistent that's where the problem lies. Excess stress can do it, and of course some are more prone depending on diet.

Methionine/SAM-e reduces the histamine load effectively for severe cases.

Increasing vitamin C and copper intake is an easy step and may be all you need to control it. If its not helping much, I suggest you try 200-400mg SAM-e to see how it affects you.
Thanks so much, I really appreciate the information!

Yes, interestingly I've been eating a lot of potatoes and chocolate lately and have been feeling great and am sleeping better. I'll try SAM-e and report back :)

Also here is a cool related thread for anyone interested:
Many Mentally Ill Have Histamine-methylation Ratio Imbalance
 

redsun

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lampofred

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All of RP stuff lowers histamine and increases methylation in a safe way (sat fat, sugar, milk as opposed to red meat). I don't think directly increasing methyl donors via supplements is healthy. Vitamin D is a powerful way to lower histamine if diet isn't cutting it.
 
OP
P

pro marker

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yea emf can definitely mess up the calcium metabolism. it excites the cells causing the calcium to be taken up by the cell and magnesium to be wasted.
so is simply supplementin magnesium a good idea? ive never supplemented and im to damn lazy to start learning about a whole new damn field
 

ReSTART

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Autistic people are often picky eaters, that may have something to do with it.
 

gaze

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so is simply supplementin magnesium a good idea? ive never supplemented and im to damn lazy to start learning about a whole new damn field
ray thinks eating more calcium is more important , because calcium activated the thyroid and lowers PTH, which helps retain magnesium. a low calcium diet causes more calcium to be took up by the cell and magnesium wasting. Vitamin D, salt, and calcium are probsbly the most important things, magnesium from milk OJ and maybe some vegetable broth is prolly enough
 

Ignoramus

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From Ray:

Genetic fadism in medicine has been increasing because of advertising for genetic tests sold directly to the public. Many people have been disturbed to learn that they have a "mutation" in a gene called MTHFR. This is an extremely common variation in a gene that relates to the activity of an enzyme that regulates methylation, i.e., the attachment of single carbon atoms to a great variety of molecules in the body.
People who have the less active form of the enzyme have a slightly higher requirement for one of the b vitamins, folate (which is found in fruits, vegetables, milk, cheese, eggs, liver,etc.) Several other nutrients, vitamins b2, b6 and b12 are involved in the regulation of folate and methylation. Large numbers of people have begun using a variety of supplements that are supposed to increase the bodies methylation capacity. Oddly it seems that the testing companies, as well as most of the doctors talking about the methylation system, haven't been talking about the association of that"mutant gene" with a much lower risk of cancer. In recent years excess methylation of DNA has been associated with stress, cancer, and aging. Choline, an important methyl donor, has been associated with prostate cancer risk (Assad,etc all.,2012).
 

Nomane Euger

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Calcium intake is supposed to release histamine and reduce stores. Methionine/SAM-e will reduce histamine by deactivating it via methylation (way more effective). Vitamin C also helps by increasing adrenal activity (norepinephrine and epinephrine) which can help reduce release of histamine from mast cells. Copper does the same and also needed for DAO.

Ideally, increased copper and vitamin C intake from the right foods such as certain tropical fruits which are high in copper, liver, dark chocolate, potatoes etc can help increase norepinephrine/epinephrine which increases sympathetic activity. Through certain adrenergic receptors (I believe beta-2), they can inhibit mast cell release of histamine.

Low cortisol can also make the problem worse because it controls immune response. Really the problem comes only with some histadelics. Its when their adrenal activity drops really low, thus histamine is not controlled well. So most are pretty good and have little issues relatively, they are driven because of it. If it is so severe that adrenal activity is nonexistent that's where the problem lies. Excess stress can do it, and of course some are more prone depending on diet.

Methionine/SAM-e reduces the histamine load effectively for severe cases.

Increasing vitamin C and copper intake is an easy step and may be all you need to control it. If its not helping much, I suggest you try 200-400mg SAM-e to see how it affects you.
redsun,according to chris masterjohn glycine is required to buffer exess methyl groups and not over methylate certains things such as dopamine,histamine,so if glycine is adequate,does a high dose of copper would not cause overmethylation of histamines as the glycine would buffer the exess methylation?when i eat to much liver i get utter dry mouth,but i dont eat gelatine.
 

redsun

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redsun,according to chris masterjohn glycine is required to buffer exess methyl groups and not over methylate certains things such as dopamine,histamine,so if glycine is adequate,does a high dose of copper would not cause overmethylation of histamines as the glycine would buffer the exess methylation?when i eat to much liver i get utter dry mouth,but i dont eat gelatine.
Copper reduces histamine because its a component of DAO, which has nothing to do with methylation so taking glycine is not going affect that.
 

Astolfo

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I was one like this. Until, of course, taking fluoxetine for the first time and getting encephalopathy. Maybe SSRIs cause copper wasting after all.
 

Explorer

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Wow, thanks for letting me know about this condition; describes me to a tee!

UndermethylationSymptomsandTraits.jpg


Does anyone have any thoughts on rectifying these issues?
I match/-ed those traits and indeeed since taking antihistamines and Peating I improved in many of those areas and became less repetitive, for some reason Ashwagandha decreased those obsessive repetitive behaviours like desire to watch porn or YouTube videos repetitively but I dislike it's mild serotonergic numbing type of effect despite it being a powerful pro-Thyroid/Androgens anti-Cortisol supplement
 

PaRa

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I match/-ed those traits and indeeed since taking antihistamines and Peating I improved in many of those areas and became less repetitive, for some reason Ashwagandha decreased those obsessive repetitive behaviours like desire to watch porn or YouTube videos repetitively but I dislike it's mild serotonergic numbing type of effect despite it being a powerful pro-Thyroid/Androgens anti-Cortisol supplement
For sure the milk coffee liver peating is literally histamine crashing diet

even being a naturalmy histadelic type, it made me histapenic as ****, always anxious cold hungry all day putting on weight no drive etc


so much better to be back on the histadelic bandwagon (ie memory reflex focus libido confidence energy digestion warmth)
 

youngsinatra

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This is most likely undermethylated, histadelic type. Also they tend to be high in certain metals such as iron or copper in their brain, which affects their neurotransmission (improves it).

I have seen an interview with Dubov. Large hands compared to body (means large feet as well) typical of histadelic. Anatomically shaped like one in general in the ways you described, though they tend to not be pale but well-colored. If they are anemic they will be pale I suppose.

Dubov has a pretty deep voice, so he is definitely not low on testosterone which is mainly responsible for voice deepening. Low DHT but high T, thus lacks facial hair/body hair but T is mainly responsible for sexual function/erections and fertility (undermethylated tend to have high libido regardless).

He is quite scrawny of course because he does not have muscle mass at all but because of the larger frame histadelics develop to dissipate heat, if he did add muscle to his frame he would look pretty good. This type has the motivation to accomplish anything but they are driven in whatever their passion/obsession is. Dubov's passion being chess, not bodybuilding.
This is really interesting. I've been studying methylation the last 2 months and I am amazed how much it impacts the body, mind, even the personality. It agrees with my ever growing naturalistic view that we are nothing but our body and brain.
 

youngsinatra

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For sure the milk coffee liver peating is literally histamine crashing diet

even being a naturalmy histadelic type, it made me histapenic as ****, always anxious cold hungry all day putting on weight no drive etc


so much better to be back on the histadelic bandwagon (ie memory reflex focus libido confidence energy digestion warmth)
Same here brother. Went from histamine intolerant (histadelic) to histapenic in a year roughly - symptoms that popped up due to this:
paranoia, anxiety (but different than the histamine-excess panic mode), feeling cold, getting hairy everywhere, inability to reach orgasm, low libido, free floating feeling, lack of focus.....
 

lampofred

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I think excess phosphate does this (by causing the brain to grow in an imbalanced way). It gives you a lot of knowledge but without the ability to communicate it well.

edit: damn i completely forgot i had commented on this thread months ago
 
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