Thalidomide (aka Contergan Aka Distaval)

Giraffe

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Jun 20, 2015
Messages
3,730
Thalidomide was promoted as a sleeping pill and to help with morning sickness. Irreversible polyneuropathy was observed, and after the drug was linked to horrific birth defects it was banned.

It has since made a comeback. In 1998 Celgene launched thalidomide as a leprosy drug. The approval for leprosy was used as an entry point. Soon the drug was used off-label in blood cancers and AIDS. In 2006 it was approved for the treatment of multiple myeloma.

Thalidomide was investigated for many other diseases. A phase III trial for the use in Crohn's disease was discontinued in 2017.

This are the adverse effects from a Crohn's trial:

adverse events thalidomide.GIF

Long-term outcomes of thalidomide in refractory Crohn’s disease

Celgene is successfully keeping off competitors, and the price for the drug has sky-rocketed.


Next generation versions with supposedly less side effects are:
  • Revlimid (Lenalidomide)
  • Imnovid (Pomalidomid)
These new drugs are even more costly.
daily costs of therapy.GIF
source

In 2017 Celgene agreed to pay $ 280 Million to resolve cancer fraud allegations.
The payment is equivalent to about two weeks’ worth of sales of Revlimid, which generated $6.97 billion in revenue for Celgene last year, according to data compiled by Bloomberg. Celgene Settles Cancer Drug Whistleblower Suit

Revlimid is predicted to be among the top 10 drugs by annual revenue in 2025.
 

yerrag

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Mar 29, 2016
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Manila
Blue babies. Terrible. Glad to not be born into that era, and glad also to be born before the autism "epidemic" hit. But feel sorry for children and parents so affected. The harm still keeps coming, although cloaked in other ways. And people as a species share many common traits as lemmings.

And nowadays, the level of dissonance is such that the more educated one is, the more one is trained to think like an intelligent machine. As in "follow your master."
 

Regina

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Aug 17, 2016
Messages
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Chicago
Thalidomide was promoted as a sleeping pill and to help with morning sickness. Irreversible polyneuropathy was observed, and after the drug was linked to horrific birth defects it was banned.

It has since made a comeback. In 1998 Celgene launched thalidomide as a leprosy drug. The approval for leprosy was used as an entry point. Soon the drug was used off-label in blood cancers and AIDS. In 2006 it was approved for the treatment of multiple myeloma.

Thalidomide was investigated for many other diseases. A phase III trial for the use in Crohn's disease was discontinued in 2017.

This are the adverse effects from a Crohn's trial:

View attachment 16763
Long-term outcomes of thalidomide in refractory Crohn’s disease

Celgene is successfully keeping off competitors, and the price for the drug has sky-rocketed.


Next generation versions with supposedly less side effects are:
  • Revlimid (Lenalidomide)
  • Imnovid (Pomalidomid)
These new drugs are even more costly.
View attachment 16764
source

In 2017 Celgene agreed to pay $ 280 Million to resolve cancer fraud allegations.


Revlimid is predicted to be among the top 10 drugs by annual revenue in 2025.
These psychopaths are so lazy. Hustling stockpiled crap.
It reminds me when I would visit elderly aunts. They offer the weirdest crap from their pantry: crackers with exp dates decades earlier, old raisins, WW2 jelly.
God bless my aunts. Probably a bad analogy because they were sweet.
More like a horrible garage sale with old underwear, used socks and other broken things to squeeze out their last penny.
But the old fart pharma cabal and their progeny needs to die off.
 
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