Testosterone Therapy May Be The Answer To Prostate Cancer

[ecstatichamster]

Dr. Peat has speculated about this, and Haidut has also.

This is a review study on "supra physiological" dosages of testosterone to treat prostate cancer.

Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions

Abstract
:
"Since Huggins defined the androgen-sensitive nature of prostate cancer (PCa), suppression of systemic testosterone (T) has remained the most effective initial therapy for advanced disease although progression inevitably occurs. From the inception of clinical efforts to suppress androgen receptor (AR) signaling by reducing AR ligands, it was also recognized that administration of T in men with castration-resistant prostate cancer (CRPC) could result in substantial clinical responses."

This is not true. Standard of care is that testosterone causes prostate cancer growth, despite the evidence that this is false.


Data from preclinical models have reproducibly shown biphasic responses to T administration, with proliferation at low androgen concentrations and growth inhibition at supraphysiological T concentrations. Many questions regarding the biphasic response of PCa to androgen treatment remain, primarily regarding the mechanisms driving these responses and how best to exploit the biphasic phenomenon clinically. Here we review the preclinical and clinical data on high dose androgen growth repression and discuss cellular pathways and mechanisms likely to be involved in mediating this response. Although meaningful clinical responses have now been observed in men with PCa treated with high dose T, not all men respond, leading to questions regarding which tumor characteristics promote response or resistance, and highlighting the need for studies designed to determine the molecular mechanism(s) driving these responses and identify predictive biomarkers



Go to your doctor and ask for T to treat your prostate cancer. Good luck with that.

 

[belcanto]

Abraham Morgentaler has been saying this for some time. Yep: Testosterone therapy in men with prostate cancer: literature review, clinical experience, and recommendations

 

[ecstatichamster]

Abraham Morgentaler has been saying this for some time. Yep: Testosterone therapy in men with prostate cancer: literature review, clinical experience, and recommendations

Thank you. Good review article.

 

[Rick K]

Dr. Peat has speculated about this, and Haidut has also.

This is a review study on "supra physiological" dosages of testosterone to treat prostate cancer.

Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions

Abstract
:
"Since Huggins defined the androgen-sensitive nature of prostate cancer (PCa), suppression of systemic testosterone (T) has remained the most effective initial therapy for advanced disease although progression inevitably occurs. From the inception of clinical efforts to suppress androgen receptor (AR) signaling by reducing AR ligands, it was also recognized that administration of T in men with castration-resistant prostate cancer (CRPC) could result in substantial clinical responses."

This is not true. Standard of care is that testosterone causes prostate cancer growth, despite the evidence that this is false.


Data from preclinical models have reproducibly shown biphasic responses to T administration, with proliferation at low androgen concentrations and growth inhibition at supraphysiological T concentrations. Many questions regarding the biphasic response of PCa to androgen treatment remain, primarily regarding the mechanisms driving these responses and how best to exploit the biphasic phenomenon clinically. Here we review the preclinical and clinical data on high dose androgen growth repression and discuss cellular pathways and mechanisms likely to be involved in mediating this response. Although meaningful clinical responses have now been observed in men with PCa treated with high dose T, not all men respond, leading to questions regarding which tumor characteristics promote response or resistance, and highlighting the need for studies designed to determine the molecular mechanism(s) driving these responses and identify predictive biomarkers



Go to your doctor and ask for T to treat your prostate cancer. Good luck with that.

I rarely respond to these posts but feel obligated here. If T were responsible for causing/promoting prostate cancer then why aren't the 18-25 yr old crowd rife with it instead of men in their 50's and 60's whose T/DHT levels are inherently significantly reduced but are almost universally afflicted with high estrogen and prolactin? This generic theory is the most insane tripe that passes for medical knowledge. There have been studies released almost 15 years ago that saw prostate cancer halted and reversed when exogenous testosterone was administered.
Man 'cured' of prostate cancer after doctors shock tumour to death with testosterone
Testosterone and prostate cancer: an evidence-based review of pathogenesis and oncologic risk
http://www.encognitive.com/files/Testosterone Replacement Endorsed by Harvard Scientists.pdf

 

[haidut]

I rarely respond to these posts but feel obligated here. If T were responsible for causing/promoting prostate cancer then why aren't the 18-25 yr old crowd rife with it instead of men in their 50's and 60's whose T/DHT levels are inherently significantly reduced but are almost universally afflicted with high estrogen and prolactin? This generic theory is the most insane tripe that passes for medical knowledge. There have been studies released almost 15 years ago that saw prostate cancer halted and reversed when exogenous testosterone was administered.
Man 'cured' of prostate cancer after doctors shock tumour to death with testosterone
Testosterone and prostate cancer: an evidence-based review of pathogenesis and oncologic risk
http://www.encognitive.com/files/Testosterone Replacement Endorsed by Harvard Scientists.pdf

I fully agree...and I have asked doctor friends the same question multiple times. All I get in response was "Knowledge does not matter clinically until it becomes regulation. All that matters is how FDA mandates we treat prostate cancer - by castration". If you want to see the fraud even more clearly wait until I post about a study showing that a DHT isomer can also treat prostate cancer! So far, the medical establishment has been getting away with the fraud because they claim T gets converted into estrogen and it was this estrogen surge that was curing these people's advanced cancers. Can you believe the absurdity of this!?? Endocrinology books firmly state that the prostate produces almost exclusively DHT from precursors like T and DHEA. In fact, it is the largest DHT-producing organ and the source of most of the DHT found in circulation. So, the whole rationale behind chemical/surgical castration is to get rid of those precursors because the prostate is so good at synthesizing DHT from them. The prostate, on the other hand, does not express much aromatase. So, when you provide it with T or DHEA, the prostate will convert the majority of the supplied precursor into DHT. In other words, it was DHT (synthesized from the injected T) likely curing these men's prostate cancer. I still can't believe nobody has emailed the authors of these case studies and pointed out the prostate-DHT-synthesis connection. It's the proverbial elephant in the room, and everybody is ignoring it.

 

[S.Seneff]

The Anti-Inflammatory Effects of Testosterone​

Vittorio Emanuele Bianchi
Author information Article notes Copyright and License information Disclaimer

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Abstract​

Low plasma testosterone (T) levels correlated with metabolic syndrome, cardiovascular diseases, and increased mortality risk. T exerts a significant effect on the regulation of adipose tissue accumulation, and in the glucose and lipids metabolism. Adipocytes are the primary source of the most important adipokines responsible for inflammation and chronic diseases. This review aims to analyze the possible effect of T on the regulation of the proinflammatory cytokines secretion.
A systematic literature search on MEDLINE, Google Scholar, and Cochrane using the combination of the following keywords: “testosterone” with “inflammation,” “cytokines,” “adiponectin, CRP, IL-1B, IL-6, TNFα, leptin” was conducted. Sixteen articles related to the effect of low T level and 18 to the effect of T therapy on proinflammatory cytokine were found.
T exerts a significant inhibitory effect on adipose tissue formation and the expression of various adipocytokines, such as leptin, TNF-α, IL-6, IL-1, and is positively correlated with adiponectin level, whereas a low T level is correlated with increased expression of markers of inflammation. Further studies are necessary to investigate the role of T, integrated with weight loss and physical activity, on its action on the mechanisms of production and regulation of proinflammatory cytokines.
Keywords: testosterone, inflammation, cytokines, adipokines, adiponectin, IL-6

The Anti-Inflammatory Effects of Testosterone

Low plasma testosterone (T) levels correlated with metabolic syndrome, cardiovascular diseases, and increased mortality risk. T exerts a significant effect on the regulation of adipose tissue accumulation, and in the glucose and lipids metabolism. Adipocytes ...

www.ncbi.nlm.nih.gov

 

[Mister]

Interesting, this endo doctor has the same opinion