Testosterone Therapy May Be The Answer To Prostate Cancer

Joined
Nov 21, 2015
Messages
8,510
Dr. Peat has speculated about this, and Haidut has also.

This is a review study on "supra physiological" dosages of testosterone to treat prostate cancer.

Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions

Abstract
:
"Since Huggins defined the androgen-sensitive nature of prostate cancer (PCa), suppression of systemic testosterone (T) has remained the most effective initial therapy for advanced disease although progression inevitably occurs. From the inception of clinical efforts to suppress androgen receptor (AR) signaling by reducing AR ligands, it was also recognized that administration of T in men with castration-resistant prostate cancer (CRPC) could result in substantial clinical responses."

This is not true. Standard of care is that testosterone causes prostate cancer growth, despite the evidence that this is false.


Data from preclinical models have reproducibly shown biphasic responses to T administration, with proliferation at low androgen concentrations and growth inhibition at supraphysiological T concentrations. Many questions regarding the biphasic response of PCa to androgen treatment remain, primarily regarding the mechanisms driving these responses and how best to exploit the biphasic phenomenon clinically. Here we review the preclinical and clinical data on high dose androgen growth repression and discuss cellular pathways and mechanisms likely to be involved in mediating this response. Although meaningful clinical responses have now been observed in men with PCa treated with high dose T, not all men respond, leading to questions regarding which tumor characteristics promote response or resistance, and highlighting the need for studies designed to determine the molecular mechanism(s) driving these responses and identify predictive biomarkers



Go to your doctor and ask for T to treat your prostate cancer. Good luck with that.
 

Rick K

Member
Joined
Feb 18, 2019
Messages
208
Dr. Peat has speculated about this, and Haidut has also.

This is a review study on "supra physiological" dosages of testosterone to treat prostate cancer.

Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions

Abstract
:
"Since Huggins defined the androgen-sensitive nature of prostate cancer (PCa), suppression of systemic testosterone (T) has remained the most effective initial therapy for advanced disease although progression inevitably occurs. From the inception of clinical efforts to suppress androgen receptor (AR) signaling by reducing AR ligands, it was also recognized that administration of T in men with castration-resistant prostate cancer (CRPC) could result in substantial clinical responses."

This is not true. Standard of care is that testosterone causes prostate cancer growth, despite the evidence that this is false.


Data from preclinical models have reproducibly shown biphasic responses to T administration, with proliferation at low androgen concentrations and growth inhibition at supraphysiological T concentrations. Many questions regarding the biphasic response of PCa to androgen treatment remain, primarily regarding the mechanisms driving these responses and how best to exploit the biphasic phenomenon clinically. Here we review the preclinical and clinical data on high dose androgen growth repression and discuss cellular pathways and mechanisms likely to be involved in mediating this response. Although meaningful clinical responses have now been observed in men with PCa treated with high dose T, not all men respond, leading to questions regarding which tumor characteristics promote response or resistance, and highlighting the need for studies designed to determine the molecular mechanism(s) driving these responses and identify predictive biomarkers



Go to your doctor and ask for T to treat your prostate cancer. Good luck with that.
I rarely respond to these posts but feel obligated here. If T were responsible for causing/promoting prostate cancer then why aren't the 18-25 yr old crowd rife with it instead of men in their 50's and 60's whose T/DHT levels are inherently significantly reduced but are almost universally afflicted with high estrogen and prolactin? This generic theory is the most insane tripe that passes for medical knowledge. There have been studies released almost 15 years ago that saw prostate cancer halted and reversed when exogenous testosterone was administered.
Man 'cured' of prostate cancer after doctors shock tumour to death with testosterone
Testosterone and prostate cancer: an evidence-based review of pathogenesis and oncologic risk
http://www.encognitive.com/files/Testosterone Replacement Endorsed by Harvard Scientists.pdf
 

haidut

Member
Joined
Mar 18, 2013
Messages
17,608
Location
USA / Europe
I rarely respond to these posts but feel obligated here. If T were responsible for causing/promoting prostate cancer then why aren't the 18-25 yr old crowd rife with it instead of men in their 50's and 60's whose T/DHT levels are inherently significantly reduced but are almost universally afflicted with high estrogen and prolactin? This generic theory is the most insane tripe that passes for medical knowledge. There have been studies released almost 15 years ago that saw prostate cancer halted and reversed when exogenous testosterone was administered.
Man 'cured' of prostate cancer after doctors shock tumour to death with testosterone
Testosterone and prostate cancer: an evidence-based review of pathogenesis and oncologic risk
http://www.encognitive.com/files/Testosterone Replacement Endorsed by Harvard Scientists.pdf

I fully agree...and I have asked doctor friends the same question multiple times. All I get in response was "Knowledge does not matter clinically until it becomes regulation. All that matters is how FDA mandates we treat prostate cancer - by castration". If you want to see the fraud even more clearly wait until I post about a study showing that a DHT isomer can also treat prostate cancer! So far, the medical establishment has been getting away with the fraud because they claim T gets converted into estrogen and it was this estrogen surge that was curing these people's advanced cancers. Can you believe the absurdity of this!?? Endocrinology books firmly state that the prostate produces almost exclusively DHT from precursors like T and DHEA. In fact, it is the largest DHT-producing organ and the source of most of the DHT found in circulation. So, the whole rationale behind chemical/surgical castration is to get rid of those precursors because the prostate is so good at synthesizing DHT from them. The prostate, on the other hand, does not express much aromatase. So, when you provide it with T or DHEA, the prostate will convert the majority of the supplied precursor into DHT. In other words, it was DHT (synthesized from the injected T) likely curing these men's prostate cancer. I still can't believe nobody has emailed the authors of these case studies and pointed out the prostate-DHT-synthesis connection. It's the proverbial elephant in the room, and everybody is ignoring it.
 
Similar threads
Thread starter Title Forum Replies Date
haidut Testosterone therapy (TRT) reverses hair loss (in women) Scientific Studies 16
ddjd Who Has Tried Testosterone Replacement Therapy Ask For Help or Advice 10
S A Peat Approach To Unavoidable Testosterone Replacement Therapy Ask For Help or Advice 19
Jean schiavi Testosterone Replacement Therapy (TRT) Hormones 4
ecstatichamster Testosterone Replacement Therapy LOWERS DHT Levels In Men Scientific Studies 9
B Peat's Thoughts On Testosterone Replacement Therapy And Steroid Usage Health 17
bzmazu More vitamin K2, more testosterone K 0
C Low dose Testosterone Ask For Help or Advice 10
haidut Oral testosterone + vitamin E may treat NAFLD, NASH, cirrhosis in humans Scientific Studies 6
haidut DHT better (and safer) than testosterone for improving blood pressure, insulin levels Scientific Studies 18
M Normal/High Testosterone but low DHEA-S Blood Work, Labs 14
cupofcoffee Trenbolone Improves Cardiometabolic Risk Factors and Myocardial Tolerance to Ischemia-Reperfusion in Male Rats With Testosterone-Deficient Metabolic S Thyroid and Hormones 0
D Where to get testosterone with no prescription? Supplements 22
Y Deeper voice in relation to testosterone levels Ask For Help or Advice 5
F My stack for testosterone, anxiety, inflammation and muscle growth: reasonable? Supplements 54
P How to extract Testosterone from water suspension? Ask For Help or Advice 9
Mito The association between testosterone, estradiol and their ratio and mortality among US men Scientific Studies 1
vetbusd Testosterone Experiment - Input wanted Blood Work, Labs 31
A Vegan diet testosterone Male Issues 9
T Aspirin and Testosterone Ask For Help or Advice 14
S Aspirin reduces testosterone and sperm count Ask For Help or Advice 89
U How to lower testosterone in women? Female Issues 17
W High DHEA but low testosterone? Blood Work, Labs 3
D Cypro Histamine2-receptor antagonism reduces testosterone and motivation? Cyproheptadine 12
Hans 7 Uncommon testosterone boosting supplements Articles & Scientific Studies 14
Lokzo This Herb Increases Testosterone, DHT, Dopamine, NGF, GDNF, Neurogenesis (Cistanche Extract) Supplements, Pharmaceutical Drugs 8
N Why testosterone, dht makes me more fatigue? Mental Issues 4
S DMSO & Testosterone Male Issues 1
Epistrophy Pregnenolone + Testosterone Base = All natural pain killer Experiments 24
B Help Dissolving Testosterone Base Powder Thyroid and Hormones 8
cupofcoffee Cordyceps militaris Fruit Body Extract increases testosterone and DHT secretion Scientific Studies 47
M High testosterone low libido Diet 23
Lokzo COVID‐19 pneumonia causes lower testosterone levels - PUBMED 2020 Scientific Studies 4
K This guy has basically no testosterone Male Issues 0
ddjd Testosterone agonises 11-beta-HSD-1 i.e. raising cortisol!! Ask For Help or Advice 4
B Testosterone shortens lifespan? Male Issues 10
TheBeard B Vitamins Doubled My Total Testosterone Levels Male Issues 105
Lokzo Testosterone As Well As Estrogen Increases Serotonin2A Receptor MRNA Scientific Studies 0
D Question For Testosterone Gurus Ask For Help or Advice 8
J Testosterone Thyroid and Hormones 13
Mr.Cacciatore Testosterone Cream On Penis Male Issues 5
P Testosterone Supplementation Help Male Issues 22
bzmazu COVID 19 AND TESTOSTERONE Viruses, Parasites, Fungus, Vaccines 0
B New Research Suggests The Conversion Of Testosterone To Estrogen In The Brain Is Crucial For Male Se Ask For Help or Advice 40
C Higher Carb To Protein Ratio Results In Higher Testosterone And Lower Cortisol In Men (1987) Scientific Studies 5
Gadreel What Dosage Of Bromocriptine Would You Recommend For Testosterone And Libido Supplements, Pharmaceutical Drugs 0
Hans The Most Essential Cornerstone To Optimize Testosterone That Cannot Be Overlooked Articles & Scientific Studies 23
Lokzo My Testosterone Enhancement Journey - SOLVED Logs 55
noqcks Testosterone Range Change? Labs 1
L Has Anyone Truly Been Able To Raise Testosterone? Blood Work, Labs 97

Similar threads

Top