Testosterone agonises 11-beta-HSD-1 i.e. raising cortisol!!

[ddjd]

Testosterone stimulates adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in a depot-specific manner in children​

Testosterone stimulates adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in a depot-specific manner in children - PubMed

Testosterone and cortisol stimulated 11beta-HSD1 and H6PDH mRNA expression and 11beta-HSD1 activity in om but not in sc adipose tissue. This suggests that these hormones may contribute to fat distribution and accumulation during childhood.

pubmed.ncbi.nlm.nih.gov

Please correct me if I'm wrong but doesn't this study show that testosterone is actually raising free cortisol. 11-beta-HSD-1 is the enzyme that converts the inactive hormone cortisone into the active hormone cortisol.

 

[LeeLemonoil]

To stimulate aromatase. Normal feedback

 

[ddjd]

To stimulate aromatase. Normal feedback

how do you mean?

 

[LeeLemonoil]

That’s it is normal physiological stuff. Test raises aromatase by way of cortisol

 

[Broco6679]

It also desensitizes the adrenals to ACTH, reducing the overall output of cortisol from the gland itself.

Testosterone Suppression of CRH-stimulated Cortisol in Men

Many people on long-term exogenous testosterone find their serum and saliva cortisol starts to drop too low — virtually nobody sees an increase.