Taurine Treatment Modulates Circadian Rhythms In Mice Fed A High Fat Diet

Discussion in 'Articles & Scientific Studies' started by paymanz, Dec 31, 2016.

  1. paymanz

    paymanz Member

    Joined:
    Jan 6, 2015
    Messages:
    2,650
    Gender:
    Male
    Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet. - PubMed - NCBI


    Close ties have been made among certain nutrients, obesity, type 2 diabetes and circadian clocks. Among nutrients, taurine has been documented as being effective against obesity and type 2 diabetes. However, the impact of taurine on circadian clocks has not been elucidated. We investigated whether taurine can modulate or correct disturbances in daily rhythms caused by a high-fat diet in mice. Male C57BL/6 mice were divided in four groups: control (C), control + taurine (C+T), high-fat diet (HFD) and HFD + taurine (HFD+T). They were administered 2% taurine in their drinking water for 10 weeks. Mice were euthanized at 6:00, 12:00, 18:00, and 24:00. HFD mice increased body weight, visceral fat and food intake, as well as higher levels of glucose, insulin and leptin, throughout the 24 h. Taurine prevented increments in food intake, body weight and visceral fat, improved glucose tolerance and insulin sensitivity and reduced disturbances in the 24 h patterns of plasma insulin and leptin. HFD downregulated the expression of clock genes Rev-erbα, Bmal1, and Per1 in pancreatic islets. Taurine normalized the gene and protein expression of PER1 in beta-cells, which suggests that it could be beneficial for the correction of daily rhythms and the amelioration of obesity and diabetes.
     
  2. Bahaa El wazzan

    Bahaa El wazzan Member

    Joined:
    Oct 5, 2016
    Messages:
    785
    Gender:
    Male
    Occupation:
    Civil engineer
    Location:
    Florida
    @paymanz interesting :)

    Why taurine break my skin so bad ?
    Did u try it before?
     
  3. BigYellowLemon

    BigYellowLemon Member

    Joined:
    Jul 6, 2016
    Messages:
    449
    We must remember that the "HFD" almost certainly means high PUFA.
     
  4. OP
    paymanz

    paymanz Member

    Joined:
    Jan 6, 2015
    Messages:
    2,650
    Gender:
    Male
    i dont know , maybe thats a short term reaction.

    i took up to 4g a day before without any negative effect.and according to haidut taurine's plateau dose is 2g a day.so with 1-2g a day you can get maximum benefits.i think ray also is ok with 1-2g a day dose.
     
  5. Bahaa El wazzan

    Bahaa El wazzan Member

    Joined:
    Oct 5, 2016
    Messages:
    785
    Gender:
    Male
    Occupation:
    Civil engineer
    Location:
    Florida
    Taurine make me my skin face break so bad

    People start asking me
    That there are blood on my face I used to take 1 to 3 gram a day

    I will try it again
    Maybe next week

    Last week I took a gram with a big healthy meal
    I took a shower
    After the shower my skin on the neck was bleeding

    But maybe it's zinc or A or D or b12

    Or maybe
    imbalance in something in my body

    By the way I have a very clean and clear skin
    So I'm sure it's taurine
     
  6. OP
    paymanz

    paymanz Member

    Joined:
    Jan 6, 2015
    Messages:
    2,650
    Gender:
    Male
    thats true , but also anyway a "high fat diet" is not a good thing, in ray's view...

    HFD also is bad for dopamine system,which is also important for circadian rhythm!
     
  7. OP
    paymanz

    paymanz Member

    Joined:
    Jan 6, 2015
    Messages:
    2,650
    Gender:
    Male
    check your diet and see if you have enough vitamin c ,manganese and as you mentioned zinc.

    bone broth may help also.
     
  8. Bahaa El wazzan

    Bahaa El wazzan Member

    Joined:
    Oct 5, 2016
    Messages:
    785
    Gender:
    Male
    Occupation:
    Civil engineer
    Location:
    Florida
    Alright thanks :)
     
  9. BigYellowLemon

    BigYellowLemon Member

    Joined:
    Jul 6, 2016
    Messages:
    449
    Ray has said he used to eat 50% fat, I think you're thinking of what he said about ketosis.

    Could you link me where you read that a high fat diet is bad for the dopaminergic system?
     
  10. OP
    paymanz

    paymanz Member

    Joined:
    Jan 6, 2015
    Messages:
    2,650
    Gender:
    Male
    Reversal Of Dopamine System Dysfunction In Response To High-fat Diet

    and ray mentioned that oxidizing fat turns on some stress signaling, and is stressful.i dont remember quote or where he said it but you can find it on forum.

    i think ray is more pro carb than he used to be years ago.
     
  11. BigYellowLemon

    BigYellowLemon Member

    Joined:
    Jul 6, 2016
    Messages:
    449
    Okay, yet again, the study you linked has rats on a 60% fat diet, almost certainly a majority of that fat is PUFA, thus a statement like "HFD is bad for dopamine system" is misleading, the type of fat matters a lot. I bet a high pufa diet would have different effects than a high sfa diet.

    Also I assume you think a high carb diet is good, yet the second study you linked says high carb low protein diets lower D2 density, I won't make any claims as the protein and fat level probably have an effect.

    I think the quote your thinking of is when Ray said that during times of stress FFA's rise... This doesn't mean FFA's are stressful.

    My main point I'm trying to make here is that any studies with high-fat diets are generally misleading because "HFD's" usually means high-pufa diets.
     
  12. OP
    paymanz

    paymanz Member

    Joined:
    Jan 6, 2015
    Messages:
    2,650
    Gender:
    Male
    unfortunately they havent mentioned what fat they used for that dopamine study.

    but ray's quote on sat fat:
    plus a high fat diet make you insulin resistant,and makes you less able to burn glucose.

    my understanding is that you shift to fat burning in stressful situations, in general.

    also high fat diet increase carnitine synthesis(PUFA highest stimulating effect , longer chain sat fat mild, and MCTGs lowest stimulating effect):



    my question is what is the point of a high fat diet?even if it come from coconut oil.whats the benefit compared to carbs?
     
  13. BigYellowLemon

    BigYellowLemon Member

    Joined:
    Jul 6, 2016
    Messages:
    449
    Here's a thread I made where we discuss this in fine-ish detail:

    Hey My Dudes [PUFA, Ketosis, Insulin Resistance]

    Ray has too many quotes going one way or the other so I don't put too much stock in any isolated quotes of his... He's all about context.

    Insulin resistance isn't necessarily a bad thing, something you can read about in the thread I linked.

    I haven't come to a satisfactory answer on which macronutrient is the best and at this point I don't really care, it has no bearing in the real world, I try not to get too hung up on conceptualization.

    With that said, I think glucose is theoretically better.
     
Loading...